Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Tara V. Bright"'
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 72:116-121
Several Streptomyces and Bacillus strains were examined for their ability to transform the anti-inflammatory drug flurbiprofen 1 to the hydroxylated metabolites that are found in humans after ingestion of this compound. Of the seven Streptomyces spp.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9303e5d0687570d9b6c655f22ac33ab8
https://doi.org/10.1016/j.molcatb.2011.05.008
https://doi.org/10.1016/j.molcatb.2011.05.008
Autor:
Maxwell J. Shaughnessy, Cormac D. Murphy, Tara V. Bright, Antal Harsanyi, Jingji Li, Graham Sandford
Publikováno v:
ChemMedChem, 2014, Vol.9(4), pp.733-736 [Peer Reviewed Journal]
In drug design, one way of improving metabolic stability is to introduce fluorine at a metabolically labile site. In the early stages of drug design, identification of such sites is challenging, and a rapid method of assessing the effect of fluorinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8caa6e4b7c6865bf225e1ed92a4ec528
https://pubmed.ncbi.nlm.nih.gov/24474678
https://pubmed.ncbi.nlm.nih.gov/24474678
Autor:
Graham Sandford, Neil K. O’Connor, Victoria L. Elder, Cormac D. Murphy, Tara V. Bright, Fay Dalton
Publikováno v:
Organic & biomolecular chemistry, 2013, Vol.11(7), pp.1135-1142 [Peer Reviewed Journal]
A significant proportion of pharmaceuticals are fluorinated and selecting the site of fluorine incorporation can be an important beneficial part a drug development process. Here we describe initial experiments aimed at the development of a general me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34bd98a28b267661b047e1401e714016
https://pubmed.ncbi.nlm.nih.gov/23299916
https://pubmed.ncbi.nlm.nih.gov/23299916