Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Tara Spires-Jones"'
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S458- (2023)
Externí odkaz:
https://doaj.org/article/fbcc1c3685b24fd084a6e17e0b406c7b
Autor:
Ileana Lorenzini, Eric Alsop, Jennifer Levy, Lauren M. Gittings, Deepti Lall, Benjamin E. Rabichow, Stephen Moore, Ryan Pevey, Lynette M. Bustos, Camelia Burciu, Divya Bhatia, Mo Singer, Justin Saul, Amanda McQuade, Makis Tzioras, Thomas A. Mota, Amber Logemann, Jamie Rose, Sandra Almeida, Fen-Biao Gao, Michael Marks, Christopher J. Donnelly, Elizabeth Hutchins, Shu-Ting Hung, Justin Ichida, Robert Bowser, Tara Spires-Jones, Mathew Blurton-Jones, Tania F. Gendron, Robert H. Baloh, Kendall Van Keuren-Jensen, Rita Sattler
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
While motor and cortical neurons are affected in C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), it remains largely unknown if and how non-neuronal cells induce or exacerbate neuronal damage. We differentiated C9orf72 ALS
Externí odkaz:
https://doaj.org/article/c5861f14d9984d6d91846ead3941a04a
Autor:
Tyler Saunders, Ciaran Gunn, Kaj Blennow, Hlin Kvartsberg, Henrik Zetterberg, Susan D. Shenkin, Simon R. Cox, Ian J. Deary, Colin Smith, Declan King, Tara Spires-Jones
Publikováno v:
Neurobiology of Disease, Vol 177, Iss , Pp 105991- (2023)
Neurogranin (Ng), a post-synaptic protein involved in memory formation, has been investigated as a biomarker in the cerebrospinal fluid (CSF) in Alzheimer's disease (AD) and ageing. CSF Ng levels are elevated in AD relative to healthy controls and co
Externí odkaz:
https://doaj.org/article/ae648440651945fc8aa54b2e27a2e90c
Autor:
Martí Colom-Cadena, Tara Spires-Jones, Henrik Zetterberg, Kaj Blennow, Anthony Caggiano, Steven T. DeKosky, Howard Fillit, John E. Harrison, Lon S. Schneider, Phillip Scheltens, Willem de Haan, Michael Grundman, Christopher H. van Dyck, Nicholas J. Izzo, Susan M. Catalano, the Synaptic Health Endpoints Working Group
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2020)
Abstract Background Synapse damage and loss are fundamental to the pathophysiology of Alzheimer’s disease (AD) and lead to reduced cognitive function. The goal of this review is to address the challenges of forging new clinical development approach
Externí odkaz:
https://doaj.org/article/1df4eea74a444af7b16f1b08d1784dd1
Publikováno v:
Neural Plasticity, Vol 2012 (2012)
Externí odkaz:
https://doaj.org/article/e882c93c21fc4fceb0b10347c1c70803
Autor:
Tara Spires-Jones, Shira Knafo
Publikováno v:
Neural Plasticity, Vol 2012 (2012)
The pathological hallmarks of Alzheimer's disease (AD)—widespread synaptic and neuronal loss and the pathological accumulation of amyloid-beta peptide (Aβ) in senile plaques, as well as hyperphosphorylated tau in neurofibrillary tangles—have bee
Externí odkaz:
https://doaj.org/article/db535c05e6d246a78b0aa15f0068c574
Autor:
Martí Colom-Cadena, Caitlin Davies, Sònia Sirisi, Ji-Eun Lee, Elizabeth Simzer, Makis Tzioras, Marta Querol-Vilaseca, Érika Sánchez-Aced, Ya Yin Chang, Kris Holt, Robert McGeachan, Jamie Rose, Jane Tulloch, Lewis Wilkins, Colin Smith, Teodora Andrian, Olivia Belbin, Sílvia Pujals, Mathew H. Horrocks, Alberto Lleó, Tara Spires-Jones
Publikováno v:
Colom Cadena, M, Davies, C, Sirisi, S, Lee, J-E, Simzer, E M, Tzioras, M, Querol-Vilaseca, M, Sanchez-Aced, E, Chang, Y Y, Holt, K, McGeachan, R I, Rose, J, Tulloch, J, Wilkins, L, Smith, C, Andrian, T, Belbin, O, Pujals, S, Horrocks, M H, Lleó, A & Spires-Jones, T L 2023, ' Synaptic oligomeric tau in Alzheimer’s disease – a potential culprit in the spread of tau pathology through the brain ', Neuron . https://doi.org/10.1016/j.neuron.2023.04.020
SummaryIn Alzheimer’s disease (AD), fibrillar tau pathology accumulates and spreads through the brain and synapses are lost. Evidence from mouse models indicates that tau spreads trans-synaptically from pre- to postsynapses and that oligomeric tau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83350f6031960b19e74616d7b3c9cb2f
https://www.pure.ed.ac.uk/ws/files/349206122/mmc2.pdf
https://www.pure.ed.ac.uk/ws/files/349206122/mmc2.pdf
Autor:
Tara Spires-Jones
Publikováno v:
Brain Communications. 5
Our editor discusses the need for standardization of neuroscience PhD training in the UK.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d2c5a50d51861467cd4eea5d70feaa5
https://doi.org/10.1093/braincomms/fcad028
https://doi.org/10.1093/braincomms/fcad028
Autor:
Tara Spires-Jones
Publikováno v:
Brain Communications. 5
Our editor introduces an early career researcher prize for the first author of a paper published in Brain Communications in 2022.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2092f008b895b6202f082e2dc4c52f02
https://doi.org/10.1093/braincomms/fcac328
https://doi.org/10.1093/braincomms/fcac328