Výsledky vyhledávání - "Tara Mleynek"

Figure S4 from The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State

Autor: Allie H. Grossmann, Sheri L. Holmen, Dean Y. Li, Shannon J. Odelberg, Andrea Bild, David A. Kircher, Coulson P. Rich, Donghan Shin, Tara Mleynek, Roger K. Wolff, Lise K. Sorensen, Jingfu Peng, Aaron Rogers, Lehi Acosta-Alvarez, Samuel W. Brady, Jae Hyuk Yoo

Figure S4. Primary tumor incidence, growth, survival and metastasis in Ptenf/f vs. Arf6Q67L mice. (a) Increased tumor incidence (% = # of mice that developed a tumor / # TVA positive, injected mice) in Ptenf/f vs. Arf6Q67L cohorts. Fisher's exact tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9def0b48b2cc83022bfecdb8248f0a63
https://doi.org/10.1158/0008-5472.22420623

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Figure S7 from The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State

Figure S7. Low expression of ARF GAP genes correlates with reduced overall survival. (a) Individual gene plots of four ARF6 GAPs (ACAP1, ADAP1, ARAP2, SMAP2), an ARF1/ARF5 GAP (AGAP2) and one predicted ARF GAP (AGFG2). n = 439 patients. (b) Individua

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https://doi.org/10.1158/0008-5472.22420614.v1

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Figure S6 from The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State

Figure S6. ARF6-GDP inhibits PI3K-AKT activation and is necessary for AKT activation. (a-b) Quantification of western blots shown in Figure 5c-d. Reproducible reduction in pAKT by Myc-ARF6T27N over expression in A375 cells (n=4), A2058 cells (n=4), a

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https://doi.org/10.1158/0008-5472.22420617

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Data from The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State

Melanoma has an unusual capacity to spread in early-stage disease, prompting aggressive clinical intervention in very thin primary tumors. Despite these proactive efforts, patients with low-risk, low-stage disease can still develop metastasis, indica

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https://doi.org/10.1158/0008-5472.c.6510696

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Figure S1 from The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State

Figure S1. Detection of HA-tagged ARF6Q67L in BrafCA;Cdkn2af/f melanoma. a) Anti-HA immunostain of FFPE sections of primary tumors with variable levels of detection of ARF6Q67L -HA. The strongest staining was observed in tumors with the highest level

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https://doi.org/10.1158/0008-5472.22420632

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Table S1 from The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State

Table S1: ARF6 pathways and related genes.

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https://doi.org/10.1158/0008-5472.22420611

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Figure S5 from The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State

Figure S5: ARF6-GTP induces morphologic changes in mouse melanoma cells. Bright field images (100x magnification) of primary mouse melanoma cell lines derived from control BrafCA;Cdkn2af/f (5588) or BrafCA;Cdkn2af/f + Arf6Q67L (6431, 6455) mice. ARF6

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https://doi.org/10.1158/0008-5472.22420620.v1

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Figure S3 from The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State

Figure S3. Arf6Q67L-HA expression in tumors from BrafCA;Cdkn2af/f;Ptenf/f mice. qRT-PCR detection of Arf6 Q67L-HA from fresh, frozen primary tumor fragments. Bars represent the absolute difference in crossing threshold (Ct) between Arf6 Q67L-HA and G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee0890550bbbd5311370d8a00302b4f
https://doi.org/10.1158/0008-5472.22420626

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