Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Tara Macrae"'
Autor:
Lixiazi He, Christian Arnold, Judith Thoma, Christian Rohde, Maksim Kholmatov, Swati Garg, Cheng‐Chih Hsiao, Linda Viol, Kaiqing Zhang, Rui Sun, Christina Schmidt, Maike Janssen, Tara MacRae, Karin Huber, Christian Thiede, Josée Hébert, Guy Sauvageau, Julia Spratte, Herbert Fluhr, Gabriela Aust, Carsten Müller‐Tidow, Christof Niehrs, Gislene Pereira, Jörg Hamann, Motomu Tanaka, Judith B Zaugg, Caroline Pabst
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 4, Pp 1-22 (2022)
Abstract The heterogeneous response of acute myeloid leukemia (AML) to current anti‐leukemic therapies is only partially explained by mutational heterogeneity. We previously identified GPR56 as a surface marker associated with poor outcome across g
Externí odkaz:
https://doaj.org/article/268002c07dd34175a0c516fb03b86c27
Autor:
Jalila Chagraoui, Bernhard Lehnertz, Simon Girard, Jean Francois Spinella, Iman Fares, Elisa Tomellini, Nadine Mayotte, Sophie Corneau, Tara MacRae, Laura Simon, Guy Sauvageau
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224900 (2019)
Elucidation of the molecular cues required to balance adult stem cell self-renewal and differentiation is critical for advancing cellular therapies. Herein, we report that the hematopoietic stem cell (HSC) self-renewal agonist UM171 triggers a balanc
Externí odkaz:
https://doaj.org/article/25a9012ffe7940d3b0c613d52f396eaf
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72884 (2013)
Accurate quantification of gene expression by qRT-PCR relies on normalization against a consistently expressed control gene. However, control genes in common use often vary greatly between samples, especially in cancer. The advent of Next Generation
Externí odkaz:
https://doaj.org/article/57cea8ce3b4c4ad59eeec2db8db37787
Autor:
Simon Fortier, Mélanie Bilodeau, Tara Macrae, Jean-Philippe Laverdure, Valeria Azcoitia, Simon Girard, Jalila Chagraoui, Nancy Ringuette, Josée Hébert, Jana Krosl, Nadine Mayotte, Guy Sauvageau
Publikováno v:
PLoS Genetics, Vol 6, Iss 12, p e1001241 (2010)
Understanding the function of important DNA elements in mammalian stem cell genomes would be enhanced by the availability of deletion collections in which segmental haploidies are precisely characterized. Using a modified Cre-loxP-based system, we no
Externí odkaz:
https://doaj.org/article/c2133da05f2146cfb7f4cceb5663d843
Autor:
Mélanie Bilodeau, Tara MacRae, Louis Gaboury, Jean-Philippe Laverdure, Marie-Pierre Hardy, Nadine Mayotte, Véronique Paradis, Sébastien Harton, Claude Perreault, Guy Sauvageau
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7500 (2009)
The cystatin protein superfamily is characterized by the presence of conserved sequences that display cysteine protease inhibitory activity (e.g., towards cathepsins). Type 1 and 2 cystatins are encoded by 25 genes of which 23 are grouped in 2 cluste
Externí odkaz:
https://doaj.org/article/88d8c170cbea486a96b875f5750e5aee
Autor:
Guy Sauvageau, Josée Hébert, Anne Marinier, Sébastien Lemieux, Yves Chantigny, Réjean Ruel, Tara MacRae, Jalila Chagraoui, Bernhard Lehnertz, Geneviève Boucher, Irène Baccelli, Jana Krosl, Marie-Eve Bordeleau, Vincent-Philippe Lavallée, Laura Simon
RUNX1 mutations identified in the Leucegene cohort. Position of mutations are indicated using NM_001754 and NM_001001890, coding for RUNX1 proteins of 480 and 453 AA respectively. VAF: variant allele frequency.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43151fe0405ba8e6b952ac63b70a7c58
https://doi.org/10.1158/1078-0432.22462088.v1
https://doi.org/10.1158/1078-0432.22462088.v1
Autor:
Guy Sauvageau, Josée Hébert, Anne Marinier, Sébastien Lemieux, Yves Chantigny, Réjean Ruel, Tara MacRae, Jalila Chagraoui, Bernhard Lehnertz, Geneviève Boucher, Irène Baccelli, Jana Krosl, Marie-Eve Bordeleau, Vincent-Philippe Lavallée, Laura Simon
Purpose: RUNX1-mutated (RUNX1mut) acute myeloid leukemia (AML) is associated with adverse outcome, highlighting the urgent need for a better genetic characterization of this AML subgroup and for the design of efficient therapeutic strategies for this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50d488c65f81ba928d9416a19c1a165
https://doi.org/10.1158/1078-0432.c.6525002
https://doi.org/10.1158/1078-0432.c.6525002
Autor:
Guy Sauvageau, Josée Hébert, Anne Marinier, Sébastien Lemieux, Yves Chantigny, Réjean Ruel, Tara MacRae, Jalila Chagraoui, Bernhard Lehnertz, Geneviève Boucher, Irène Baccelli, Jana Krosl, Marie-Eve Bordeleau, Vincent-Philippe Lavallée, Laura Simon
Supplementary Figure 1. Additional examples of genes most correlated (> 0.50 or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e10d282dfea7412d0357ff295019d0d
https://doi.org/10.1158/1078-0432.22462094.v1
https://doi.org/10.1158/1078-0432.22462094.v1
Autor:
Réjean Ruel, Deanne Gracias, Bernhard Lehnertz, Jasmin Coulombe-Huntington, Geneviève Boucher, Richard Bisaillon, Guy Sauvageau, Sébastien Lemieux, Marie-Eve Bordeleau, Tara MacRae, Thierry Bertomeu, Nadine Mayotte, Josée Hébert, Céline Moison, Anne Marinier, Patrick Gendron, Mike Tyers, Isabel Boivin, Jana Krosl, Irène Baccelli, Frédéric Barabé, Rodrigo Mendoza-Sanchez, Vincent-Philippe Lavallée, Caroline Pabst, Nandita Noronha
Publikováno v:
Blood Advances
Key Points Inhibition of RAB protein function mediates the anti–acute myeloid leukemia activity of statins.Statin sensitivity is associated with enhanced vesicle-mediated traffic.
Visual Abstract
Cholesterol homeostasis has been proposed
Visual Abstract
Cholesterol homeostasis has been proposed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c795ab9cf3038006282d431d6e784f4
https://doi.org/10.1182/bloodadvances.2021006047
https://doi.org/10.1182/bloodadvances.2021006047
Autor:
Tara MacRae, Deanne Gracias, Nadine Mayotte, Sophie Corneau, Elisa Tomellini, Guy Sauvageau, Jalila Chagraoui, Isabel Boivin, Bernhard Lehnertz, Aurelie Durand
Publikováno v:
Blood. 138:2642-2654
Hematopoietic stem cells (HSCs) sustain blood cell homeostasis throughout life and can regenerate all blood lineages after transplantation. Despite this clear functional definition, highly enriched isolation of human HSCs can currently only be achiev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511034c4dc235010db059dabb0731c47
https://doi.org/10.1182/blood.2021010745
https://doi.org/10.1182/blood.2021010745