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of 8
pro vyhledávání: '"Tara M. Love"'
Autor:
Roy Khalife, Tara M. Love, Lara Sucheston-Campbell, Michael J. Clark, Helle Sorensen, Shuba Krishna, Anthony Magliocco
Publikováno v:
Journal of Molecular Pathology, Vol 5, Iss 1, Pp 81-95 (2024)
Variant annotation is an important step in deciphering the functional impact of genomic variants and their association with diseases. In this study, we analyzed 80 pan-cancer cases that underwent comprehensive genomic testing and compared the auto-cl
Externí odkaz:
https://doaj.org/article/4e6cb36828fc4ae6a2540da897e7724f
Publikováno v:
PLoS ONE, Vol 17, Iss 5 (2022)
Molecular tumor boards (MTBs) require specialized activities to leverage genomic data for therapeutic decision-making. Currently, there are no defined standards for implementing, executing, and tracking the impact of MTBs. This study describes the de
Externí odkaz:
https://doaj.org/article/e218fea7bb0948739714c257780fe0b7
Autor:
Jennifer R. Brown, Carl D. Novina, Tara M. Love, Victoria Del Gaizo Moore, Michael Certo, Anthony Letai
Publikováno v:
Journal of Clinical Investigation. 117:112-121
Antiapoptotic B cell leukemia/lymphoma 2 (BCL2) family proteins are expressed in many cancers, but the circumstances under which these proteins are necessary for tumor maintenance are poorly understood. We exploited a novel functional assay that uses
Autor:
Tara M. Love, Rowena de Jesus, Jennifer A. Kean, Andrew J. Leger, Brian Schaffhausen, Qing Sheng
Publikováno v:
Journal of Virology. 79:4180-4190
Polyomavirus large T antigen (LT) has a direct role in viral replication and a profound effect on cell phenotype. It promotes cell cycle progression, immortalizes primary cells, blocks differentiation, and causes apoptosis. While much of large T func
Publikováno v:
Journal of Virology. 74:5280-5290
Polyomaviruses (Pys) have provided valuable models because the cellular pathways they use are generally important for cell function. The multifunctional large T antigens (LTs) represent one example. Their most obvious role is in DNA replication. Muri
Autor:
Tara M. Love, David E. Housman, John G. Doench, Donna Neuberg, Carl D. Novina, Maja M. Janas, Kristen E. Stevenson, Po-Hao Chen, Jonathan M. Shaffer, Christopher B. Burge, Dimitrios Iliopoulos, Karlheinz Semmelmann, Abigail S. Harris, Eric T. Wang, Subrahmanyam Yerramilli
Publikováno v:
Molecular cell. 46(2)
MicroRNAs (miRNAs) regulate physiological and pathological processes by inducing posttranscriptional repression of target messenger RNAs (mRNAs) via incompletely understood mechanisms. To discover factors required for human miRNA activity, we perform
Publikováno v:
The Journal of allergy and clinical immunology. 121(2)
RNA interference (RNAi) describes a set of natural processes in which genes are silenced by small RNAs. RNAi has been widely used as an experimental tool that has recently become the focus of drug development efforts to treat a variety of diseases an
Publikováno v:
Molecular cell. 22(4)
microRNAs (miRNAs) are a large class of endogenous short RNAs that repress gene expression. Many miRNAs are conserved throughout evolution, and dysregulation of miRNA pathways has been correlated with an increasing number of human diseases. In animal