Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Tara L. Spires"'
Autor:
María Pagnon de la Vega, Stina Syvänen, Vilmantas Giedraitis, Monique Hooley, Evangelos Konstantinidis, Silvio R. Meier, Johanna Rokka, Jonas Eriksson, Ximena Aguilar, Tara L. Spires-Jones, Lars Lannfelt, Lars N. G. Nilsson, Anna Erlandsson, Greta Hultqvist, Martin Ingelsson, Dag Sehlin
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Deposition of amyloid beta (Aβ) into plaques is a major hallmark of Alzheimer’s disease (AD). Different amyloid precursor protein (APP) mutations cause early-onset AD by altering the production or aggregation properties of Aβ. We recentl
Externí odkaz:
https://doaj.org/article/e1e6c9096c0f4e3e9f714a2564198215
Autor:
Zsofia I. Laszlo, Nicole Hindley, Anna Sanchez Avila, Rachel A. Kline, Samantha L. Eaton, Douglas J. Lamont, Colin Smith, Tara L. Spires-Jones, Thomas M. Wishart, Christopher M. Henstridge
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-20 (2022)
Abstract Increasing evidence suggests synaptic dysfunction is a central and possibly triggering factor in Amyotrophic Lateral Sclerosis (ALS). Despite this, we still know very little about the molecular profile of an ALS synapse. To address this gap,
Externí odkaz:
https://doaj.org/article/a5dc3dda62ae45789b1d7df6f27a7cc3
Autor:
Zoeb Jiwaji, Sachin S. Tiwari, Rolando X. Avilés-Reyes, Monique Hooley, David Hampton, Megan Torvell, Delinda A. Johnson, Jamie McQueen, Paul Baxter, Kayalvizhi Sabari-Sankar, Jing Qiu, Xin He, Jill Fowler, James Febery, Jenna Gregory, Jamie Rose, Jane Tulloch, Jamie Loan, David Story, Karina McDade, Amy M. Smith, Peta Greer, Matthew Ball, Peter C. Kind, Paul M. Matthews, Colin Smith, Owen Dando, Tara L. Spires-Jones, Jeffrey A. Johnson, Siddharthan Chandran, Giles E. Hardingham
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Alzheimer’s disease is associated with changes in astrocytes. Here the authors investigated the astrocyte translatome associated with amyloid-ß and tau pathology.
Externí odkaz:
https://doaj.org/article/3684566e972d48bda37be69378c00e42
Autor:
Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G. Herrmann, Marti Colom-Cadena, Makis Tzioras, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher M. Henstridge, Douglas Lamont, Thomas M. Wishart, Tara L. Spires-Jones
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently observed that the strongest genetic risk factor for sporadic AD, ap
Externí odkaz:
https://doaj.org/article/ad825fe296684195b97f38283374885a
Autor:
Samantha K. Barton, Jenna M. Gregory, Bhuvaneish T. Selvaraj, Karina McDade, Christopher M. Henstridge, Tara L. Spires-Jones, Owen G. James, Arpan R. Mehta, David Story, Karen Burr, Dario Magnani, Adrian M. Isaacs, Colin Smith, Siddharthan Chandran
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Pathological hallmarks of amyotrophic lateral sclerosis (ALS), including protein misfolding, are well established in oligodendrocytes. More recently, an RNA trafficking deficit of key myelin proteins has been suggested in oligodendrocytes in ALS but
Externí odkaz:
https://doaj.org/article/b45e0692110c4e06a184d5b851be4204
Autor:
Anna J. Stevenson, Daniel L. McCartney, Sarah E. Harris, Adele M. Taylor, Paul Redmond, John M. Starr, Qian Zhang, Allan F. McRae, Naomi R. Wray, Tara L. Spires-Jones, Barry W. McColl, Andrew M. McIntosh, Ian J. Deary, Riccardo E. Marioni
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-10 (2018)
Abstract Background Epigenetic age acceleration (an older methylation age compared to chronological age) correlates strongly with various age-related morbidities and mortality. Chronic systemic inflammation is thought to be a hallmark of ageing, but
Externí odkaz:
https://doaj.org/article/0c706a1df6694049b0d814a5455edd67
Autor:
Jamie Toombs, Lindsay Panther, Loren Ornelas, Chunyan Liu, Emilda Gomez, Raquel Martín-Ibáñez, Simon R. Cox, Stuart J. Ritchie, Sarah E. Harris, Adele Taylor, Paul Redmond, Tom C. Russ, Lee Murphy, James D. Cooper, Karen Burr, Bhuvaneish T. Selvaraj, Cathy Browne, Clive N. Svendsen, Sally A. Cowley, Ian J. Deary, Siddharthan Chandran, Tara L. Spires-Jones, Dhruv Sareen
Publikováno v:
Stem Cell Research, Vol 46, Iss , Pp 101851- (2020)
Cognitive decline is among the most feared aspects of ageing. We have generated induced pluripotent stem cells (iPSCs) from 24 people from the Lothian Birth Cohort 1936, whose cognitive ability was tested in childhood and in older age. Peripheral blo
Externí odkaz:
https://doaj.org/article/2ec95fdbbd9044aca4c3416f0ee6b4db
Autor:
Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P. Fjeldstad, Will Calkin, Leo Murison, Rosemary J. Jackson, Makis Tzioras, Anna Stevenson, Marie d’Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M. Henstridge, Giles E. Hardingham, Tara L. Spires-Jones
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3592-3604.e5 (2019)
Summary: A key knowledge gap blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms of the tau protein cooperate in causing disease phenotype
Externí odkaz:
https://doaj.org/article/5c607706c23f4f7d92a682e925ca0372
Autor:
Lujia Zhou, Joseph McInnes, Keimpe Wierda, Matthew Holt, Abigail G. Herrmann, Rosemary J. Jackson, Yu-Chun Wang, Jef Swerts, Jelle Beyens, Katarzyna Miskiewicz, Sven Vilain, Ilse Dewachter, Diederik Moechars, Bart De Strooper, Tara L. Spires-Jones, Joris De Wit, Patrik Verstreken
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Mislocalisation of tau occurs in several neurodegenerative diseases and is thought to contribute to synaptic function. The authors show that presynaptically, tau binds to synaptic vesicles via the N-terminus which contributes to synaptic dysfunction.
Externí odkaz:
https://doaj.org/article/29d0e0f57e0642e99099f85ef88b2518
Autor:
Congyu Xu, Linjie Yu, Jinxing Hou, Rosemary J. Jackson, He Wang, Chaoli Huang, Tingting Liu, Qihui Wang, Xiaochuan Zou, Richard G. Morris, Tara L. Spires-Jones, Zhongzhou Yang, Zhenyu Yin, Yun Xu, Guiquan Chen
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Decreased expression but increased activity of PDK1 has been observed in neurodegenerative disease. To study in vivo function of PDK1 in neuron survival during cortical development, we generate forebrain-specific PDK1 conditional knockout (cKO) mice.
Externí odkaz:
https://doaj.org/article/fa20350283234f61ba26a2251002152c