Výsledky vyhledávání - "Tara L. Hogenson"

Akademický článek

Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion

Autor: Omar L. Gutierrez-Ruiz, Katherine M. Johnson, Eugene W. Krueger, Roseanne E. Nooren, Nicole Cruz-Reyes, Carrie Jo Heppelmann, Tara L. Hogenson, Martin E. Fernandez-Zapico, Mark A. McNiven, Gina L. Razidlo

Publikováno v: Cell Reports, Vol 42, Iss 9, Pp 113042- (2023)

Summary: Amplified lysosome activity is a hallmark of pancreatic ductal adenocarcinoma (PDAC) orchestrated by oncogenic KRAS that mediates tumor growth and metastasis, though the mechanisms underlying this phenomenon remain unclear. Using comparative

Externí odkaz: https://doaj.org/article/9d68ce2bcbb5492f9eed1b1feddc32ac

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Akademický článek

Culture media composition influences patient-derived organoid ability to predict therapeutic responses in gastrointestinal cancers

Publikováno v: JCI Insight, Vol 7, Iss 22 (2022)

BACKGROUND A patient-derived organoid (PDO) platform may serve as a promising tool for translational cancer research. In this study, we evaluated PDO’s ability to predict clinical response to gastrointestinal (GI) cancers.METHODS We generated PDOs

Externí odkaz: https://doaj.org/article/f973dfbdbe53458f81a1c8da0742e768

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Akademický článek

Anticachectic regulator analysis reveals Perp-dependent antitumorigenic properties of 3-methyladenine in pancreatic cancer

Autor: Aneesha Dasgupta, Paige C. Arneson-Wissink, Rebecca E. Schmitt, Dong Seong Cho, Alexandra M. Ducharme, Tara L. Hogenson, Eugene W. Krueger, William R. Bamlet, Lizhi Zhang, Gina L. Razidlo, Martin E. Fernandez-Zapico, Jason D. Doles

Publikováno v: JCI Insight, Vol 7, Iss 2 (2022)

Approximately 80% of pancreatic cancer patients suffer from cachexia, and one-third die due to cachexia-related complications such as respiratory failure and cardiac arrest. Although there has been considerable research into cachexia mechanisms and i

Externí odkaz: https://doaj.org/article/fd3089a0330d47c2a75cc830a73c9afa

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Akademický článek

Back to the drawing board: Re-thinking the role of GLI1 in pancreatic carcinogenesis [version 2; referees: 3 approved]

Autor: Tara L. Hogenson, Matthias Lauth, Marina Pasca diMagliano, Martin E. Fernandez-Zapico

Publikováno v: F1000Research, Vol 3 (2016)

Aberrant activation of the transcription factor GLI1, a central effector of the Hedgehog (HH) pathway, is associated with several malignancies, including pancreatic ductal adenocarcinoma (PDAC), one of most deadly human cancers. GLI1 has been describ

Externí odkaz: https://doaj.org/article/7e329db6d22642af99b932e6265454bf

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Akademický článek

Patient‐derived organoids, creating a new window of opportunities for pancreatic cancer patients

Autor: Sandhya Sandhya, Tara L Hogenson, Martin E Fernandez‐Zapico

Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 4, Pp 1-2 (2022)

Abstract Standard‐of‐care regimens for pancreatic ductal adenocarcinoma (PDAC) include a combination of chemotherapies, which are associated with toxicity and eventually tumor resistance. The lack of relevant tool to identify and evaluate new the

Externí odkaz: https://doaj.org/article/7a1f1940614343859219b617c29a232c

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