Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tara L. Archuleta"'
Autor:
Alexandra K. Davies, Daniel N. Itzhak, James R. Edgar, Tara L. Archuleta, Jennifer Hirst, Lauren P. Jackson, Margaret S. Robinson, Georg H. H. Borner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
Adaptor protein complex 4 (AP-4) deficiency causes a severe neurological disorder via an unknown mechanism. Here, the authors reveal cargo and machinery of the AP-4 transport pathway, and propose that AP-4 mediates spatial regulation of autophagy thr
Externí odkaz:
https://doaj.org/article/ff52a2aa9d09459f8fa30ecd00dc3289
Autor:
Wolfgang Peti, Lucy C. Robinson, Tara L. Archuleta, Rini Ravindran, Rebecca Page, Meng S. Choy, Thomas M. Moon, Kelly Tatchell, Johnny A Bray, Wuxian Shi
Publikováno v:
Proceedings of the National Academy of Sciences. 116:20472-20481
The metalloenzyme protein phosphatase 1 (PP1), which is responsible for ≥50% of all dephosphorylation reactions, is regulated by scores of regulatory proteins, including the highly conserved SDS22 protein. SDS22 has numerous diverse functions, surp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0beb7a6e5bf0b7210828d51e9e75846b
https://doi.org/10.1073/pnas.1908718116
https://doi.org/10.1073/pnas.1908718116
Autor:
Tara L Archuleta, Benjamin W Spiller
Publikováno v:
PLoS Pathogens, Vol 10, Iss 11, p e1004498 (2014)
Many Gram-negative bacteria use Type Three Secretion Systems (T3SS) to deliver effector proteins into host cells. These protein delivery machines are composed of cytosolic components that recognize substrates and generate the force needed for translo
Externí odkaz:
https://doaj.org/article/c290f60d63ee45e4acd104a2d631a910
Publikováno v:
Acta crystallographica. Section F, Structural biology communications. 74(Pt 12)
Protein phosphatase 1 (PP1) dephosphorylates hundreds of key biological targets by associating with nearly 200 regulatory proteins to form highly specific holoenzymes. The vast majority of regulators are intrinsically disordered proteins (IDPs) and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6b3a0cc5b50317dcb3832af5be8e04
https://pubmed.ncbi.nlm.nih.gov/30511677
https://pubmed.ncbi.nlm.nih.gov/30511677
Autor:
Jennifer Hirst, James R. Edgar, Alexandra K Davies, Tara L. Archuleta, Margaret S. Robinson, Daniel N. Itzhak, Lauren P. Jackson, Georg H. H. Borner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
Nature Communications
Nature Communications
Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose function has largely remained elusive. In humans, AP-4 deficiency causes a severe neurological disorder of unknown aetiology. We apply unbiased proteomic methods, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d01061b08fa52fb684c63102e9114b
https://doi.org/10.1038/s41467-018-06172-7
https://doi.org/10.1038/s41467-018-06172-7
Autor:
Meredith N. Frazier, Nicole Creanza, Tara L. Archuleta, Joel M. Harp, Airlie J. McCoy, Amy Kendall, Anderson E. Monken, Lauren P. Jackson
Publikováno v:
Traffic (Copenhagen, Denmark). 18(9)
Tepsin is currently the only accessory trafficking protein identified in adaptor-related protein 4 (AP4)-coated vesicles originating at the trans-Golgi network (TGN). The molecular basis for interactions between AP4 subunits and motifs in the tepsin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4962751c762ff87cafbf5f3a8ad2ce
https://pubmed.ncbi.nlm.nih.gov/28691777
https://pubmed.ncbi.nlm.nih.gov/28691777
Autor:
Ryoma Ohi, Chauca A. English, Stephen Lory, Benjamin W. Spiller, Tara L. Archuleta, Cammie F. Lesser, Yaqing Du, Melanie D. Ohi
Publikováno v:
Journal of Biological Chemistry. 286:33992-33998
Chlamydia species are obligate intracellular pathogens that utilize a type three secretion system to manipulate host cell processes. Genetic manipulations are currently not possible in Chlamydia, necessitating study of effector proteins in heterologo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a2ad807bbb60bdeed24efafb81e1bb
https://doi.org/10.1074/jbc.m111.258426
https://doi.org/10.1074/jbc.m111.258426
Autor:
Andrew M. Lemieux, Vitoon Saengsirisuwan, Mary K. Teachey, Erik J. Henriksen, Katherine A. Lindborg, John S. Kim, Tara L. Archuleta
Oxidative stress is characterized as an imbalance between the cellular production of oxidants and the cellular antioxidant defenses and contributes to the development of numerous cardiovascular and metabolic disorders, including hypertension and insu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2966ee1bd056b053032c76cf9124d7c
https://europepmc.org/articles/PMC2767452/
https://europepmc.org/articles/PMC2767452/
Publikováno v:
The FASEB Journal. 22
Oxidative stress, the imbalance of oxidant production and the antioxidant defenses in the cell, can impair the functionality of elements of the insulin-signaling pathway that regulates glucose metabolism in skeletal muscle. In this context, the prima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce6a1941096dbb09e2c97ca79f00b103
https://doi.org/10.1096/fasebj.22.1_supplement.1016.9
https://doi.org/10.1096/fasebj.22.1_supplement.1016.9
Autor:
Oliver Hasselwander, Mary K. Teachey, Katherine A. Lindborg, Erik J. Henriksen, Tara L. Archuleta, Markus Matuschek, Veronika Somoza, Nicholas B. Harrell, Cody J. Diehl, Gaby Andersen, Elizabeth A. Muellenbach
Publikováno v:
Metabolism: clinical and experimental. 57(10)
Oxidative stress and protein glycation can contribute to the development of insulin resistance and complications associated with type 2 diabetes mellitus. The antioxidant alpha-lipoic acid (ALA) reduces oxidative stress and the formation of advanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1068a5988cfbbeaa588b29c50b9e44
https://pubmed.ncbi.nlm.nih.gov/18803954
https://pubmed.ncbi.nlm.nih.gov/18803954