Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Tara L Spires‐Jones"'
Autor:
Michael JD Daniels, Lucas Lefevre, Stefan Szymkowiak, Alice Drake, Laura McCulloch, Makis Tzioras, Jack Barrington, Owen R Dando, Xin He, Mehreen Mohammad, Hiroki Sasaguri, Takashi Saito, Takaomi C Saido, Tara L Spires-Jones, Barry W McColl
Publikováno v:
eLife, Vol 12 (2023)
Microglial endolysosomal (dys)function is strongly implicated in neurodegenerative disease. Transcriptomic studies show that a microglial state characterised by a set of genes involved in endolysosomal function is induced in both mouse Alzheimer’s
Externí odkaz:
https://doaj.org/article/b34f7f5ec669424295c17df5e3b3199f
Autor:
Qiaochu Li, Daniel-Cosmin Marcu, Ottavia Palazzo, Frances Turner, Declan King, Tara L Spires-Jones, Melanie I Stefan, Karl Emanuel Busch
Publikováno v:
eLife, Vol 9 (2020)
The ability to learn progressively declines with age. Neural hyperactivity has been implicated in impairing cognitive plasticity with age, but the molecular mechanisms remain elusive. Here, we show that chronic excitation of the Caenorhabditis elegan
Externí odkaz:
https://doaj.org/article/fa3083e036904e3e8216444c52f401e0
Autor:
Nicholas J Izzo, Jinbin Xu, Chenbo Zeng, Molly J Kirk, Kelsie Mozzoni, Colleen Silky, Courtney Rehak, Raymond Yurko, Gary Look, Gilbert Rishton, Hank Safferstein, Carlos Cruchaga, Alison Goate, Michael A Cahill, Ottavio Arancio, Robert H Mach, Rolf Craven, Elizabeth Head, Harry LeVine, Tara L Spires-Jones, Susan M Catalano
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111899 (2014)
Amyloid beta (Abeta) 1-42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI) and disrupt synaptic plasticity processes that underlie memory formation. Synaptic binding of Abeta oligomers to several putative receptor prote
Externí odkaz:
https://doaj.org/article/b30b103a4849402a9db579ed34d6a602
Autor:
Khampaseuth Rasakham, Heath D Schmidt, Kevin Kay, Megan N Huizenga, Narghes Calcagno, R Christopher Pierce, Tara L Spires-Jones, Ghazaleh Sadri-Vakili
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102524 (2014)
Chronic cocaine exposure in both human addicts and in rodent models of addiction reduces prefrontal cortical activity, which subsequently dysregulates reward processing and higher order executive function. The net effect of this impaired gating of be
Externí odkaz:
https://doaj.org/article/0c091ee2dd6b4aefa220fa9cd236a578
Autor:
Katherine J Kopeikina, Susanne Wegmann, Rose Pitstick, George A Carlson, Brian J Bacskai, Rebecca A Betensky, Bradley T Hyman, Tara L Spires-Jones
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80834 (2013)
Neurofibrillary tangles (NFTs) of tau are one of the defining hallmarks of Alzheimer's disease (AD), and are closely associated with neuronal degeneration. Although it has been suggested that calcium dysregulation is important to AD pathogenesis, few
Externí odkaz:
https://doaj.org/article/020431432a1f4c968396a817fd88776f
Autor:
Phillip B Jones, Kenneth W Adams, Anete Rozkalne, Tara L Spires-Jones, Tammy T Hshieh, Tadafumi Hashimoto, Christine A F von Armin, Mathew Mielke, Brian J Bacskai, Bradley T Hyman
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14586 (2011)
We applied a novel application of FLIM-FRET to in situ measurement and quantification of protein interactions to explore isoform specific differences in Aβ-ApoE interaction and ApoE tertiary conformation in senile plaques in human Alzheimer brain. A
Externí odkaz:
https://doaj.org/article/a075653211154ded91f8cb220fe6a7ec
Publikováno v:
Nature Reviews Neurology. 19:19-38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3bb51724f4bb5deb0400245cb1c029f
https://doi.org/10.1038/s41582-022-00749-z
https://doi.org/10.1038/s41582-022-00749-z
Publikováno v:
European Journal of Neuroscience. 56:5337-5341
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef65e69c622bef23fef47f75eaffcbd
https://doi.org/10.1111/ejn.15857
https://doi.org/10.1111/ejn.15857
Autor:
Nicola Wrobel, Jonathan Mill, Riccardo E. Marioni, Barry W. McColl, Lee Murphy, Anna J. Stevenson, Eilis Hannon, Colin Smith, Robert F. Hillary, Ian J. Deary, Andrew M. McIntosh, Sarah E. Harris, Adele M. Taylor, Sarah McCafferty, Makis Tzioras, Paul Redmond, Simon R. Cox, Tara L. Spires-Jones, Daniel L. McCartney, Gemma Shireby, Declan King, Tom C. Russ
Publikováno v:
European Journal of Neuroscience. 56:5637-5649
Inflammation and ageing-related DNA methylation patterns in the blood have been linked to a variety of morbidities, including cognitive decline and neurodegenerative disease. However, it is unclear how these blood-based patterns relate to patterns wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35dd352f72d77fd89546cea4a0b2aba5
https://doi.org/10.1111/ejn.15661
https://doi.org/10.1111/ejn.15661
Autor:
Tyler S Saunders, Francesca E Pozzolo, Amanda Heslegrave, Declan King, Robert I McGeachan, Maxwell P Spires-Jones, Sarah E Harris, Craig Ritchie, Graciela Muniz-Terrera, Ian J Deary, Simon R Cox, Henrik Zetterberg, Tara L Spires-Jones
Publikováno v:
Saunders, T, Pozzolo, F E, Heslegrave, A, King, D, McGeachan, R, Spires-Jones, M P, Harris, S E, Ritchie, C, Terrera, GM, Deary, I J, Cox, S R, Zetterberg, H & Spires-Jones, T 2023, ' Predictive blood biomarkers and brain changes associated with age-related cognitive decline ', Brain Communications . https://doi.org/10.1093/braincomms/fcad113
Growing evidence supports the use of plasma levels of tau phosphorylated at threonine 181, amyloid-β, neurofilament light and glial fibrillary acidic protein as promising biomarkers for Alzheimer’s disease. While these blood biomarkers are promisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9b53ac8fbc4ae632ff07e1be0e2d3d
https://doi.org/10.1093/braincomms/fcad113
https://doi.org/10.1093/braincomms/fcad113