Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.

Autor: Tara L Davis, John R Walker, Valérie Campagna-Slater, Patrick J Finerty, Ragika Paramanathan, Galina Bernstein, Farrell MacKenzie, Wolfram Tempel, Hui Ouyang, Wen Hwa Lee, Elan Z Eisenmesser, Sirano Dhe-Paganon

Publikováno v: PLoS Biology, Vol 8, Iss 7, p e1000439 (2010)

Peptidyl-prolyl isomerases catalyze the conversion between cis and trans isomers of proline. The cyclophilin family of peptidyl-prolyl isomerases is well known for being the target of the immunosuppressive drug cyclosporin, used to combat organ trans

Externí odkaz: https://doaj.org/article/741f8b0aed584ccc95c73ca0fbd156ff

Phosphorylation of the RNA-binding protein Dazl by MAPKAP kinase 2 regulates spermatogenesis

Autor: Patrick A. Williams, Jasmine D. Peake, Michael S. Krug, Simon Cocklin, Todd I. Strochlic, Emily A. McMillan, Tara L. Davis

Publikováno v: Molecular Biology of the Cell

Developing male germ cells are exquisitely sensitive to stress and rely on RNA-binding proteins for posttranscriptional gene expression. Phosphorylation of the germ cell–specific RNA-binding protein deleted in azoospermia-like (Dazl) by the stress-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2199ad5b852e3312cfe37ac60ea13c1f
http://europepmc.org/articles/PMC4966976

Nuclear cyclophilins affect spliceosome assembly and function in vitro

Autor: Beth Adams, Tara L. Davis, Melissa S. Jurica, Miranda N. Coates, S. RaElle Jackson

Publikováno v: The Biochemical journal, vol 469, iss 2
Adams, BM; Coates, MN; Jackson, SRE; Jurica, MS; & Davis, TL. (2015). Nuclear cyclophilins affect spliceosome assembly and function in vitro. Biochemical Journal, 469(2), 223-233. doi: 10.1042/BJ20150396. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/6m50x5f6

© 2015 Authors; published by Portland Press Limited. Cyclophilins are ubiquitously expressed proteins that bind to prolines and can catalyse cis/trans isomerization of proline residues. There are 17 annotated members of the cyclophilin family in hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd3c0b110411a06c0f8fa98d6b65448
https://doi.org/10.1042/bj20150396

Development of Fluorescent Substrates and Assays for the Key Autophagy-Related Cysteine Protease Enzyme, ATG4B

Autor: Tara L. Davis, Thanh G. Nguyen, Tom A. Pfeifer, Nicolette S. Honson, Nag S. Kumar, Robert N. Young, Suzana Kovacic, Sirano Dhe-Paganon, Steven Arns

Publikováno v: ASSAY and Drug Development Technologies. 12:176-189

The cysteine protease ATG4B plays a role in key steps of the autophagy process and is of interest as a potential therapeutic target. At an early step, ATG4B cleaves proLC3 isoforms to form LC3-I for subsequent lipidation to form LC3-II and autophagos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7075263ec315b65f948c6419b397552a
https://doi.org/10.1089/adt.2013.561

A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation

Autor: John R. Walker, Farell Mackenzie, Tara L. Davis, Leanne E. Wybenga-Groot, E.M. Newman, P.J. Finerty, Dene R. Littler, Sirano Dhe-Paganon

Publikováno v: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 66:143-151

The AMP-activated protein kinase (AMPK) is a highly conserved trimeric protein complex that is responsible for energy homeostasis in eukaryotic cells. Here, a 1.9 A resolution crystal structure of the isolated kinase domain from the alpha2 subunit of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7521215b13f1619933210d8c6d51f21b
https://doi.org/10.1107/s1744309109052543