Structural and Functional Insights into Human Nuclear Cyclophilins

Autor: Caroline Rajiv, Tara L. Davis

Publikováno v: Biomolecules, Vol 8, Iss 4, p 161 (2018)

The peptidyl prolyl isomerases (PPI) of the cyclophilin type are distributed throughout human cells, including eight found solely in the nucleus. Nuclear cyclophilins are involved in complexes that regulate chromatin modification, transcription, and

Externí odkaz: https://doaj.org/article/48beb22ec505450190a024e442e9b1ac

Phosphorylation of the RNA-binding protein Dazl by MAPKAP kinase 2 regulates spermatogenesis

Autor: Patrick A. Williams, Jasmine D. Peake, Michael S. Krug, Simon Cocklin, Todd I. Strochlic, Emily A. McMillan, Tara L. Davis

Publikováno v: Molecular Biology of the Cell

Developing male germ cells are exquisitely sensitive to stress and rely on RNA-binding proteins for posttranscriptional gene expression. Phosphorylation of the germ cell–specific RNA-binding protein deleted in azoospermia-like (Dazl) by the stress-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2199ad5b852e3312cfe37ac60ea13c1f
http://europepmc.org/articles/PMC4966976

Nuclear cyclophilins affect spliceosome assembly and function in vitro

Autor: Beth Adams, Tara L. Davis, Melissa S. Jurica, Miranda N. Coates, S. RaElle Jackson

Publikováno v: The Biochemical journal, vol 469, iss 2
Adams, BM; Coates, MN; Jackson, SRE; Jurica, MS; & Davis, TL. (2015). Nuclear cyclophilins affect spliceosome assembly and function in vitro. Biochemical Journal, 469(2), 223-233. doi: 10.1042/BJ20150396. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/6m50x5f6

© 2015 Authors; published by Portland Press Limited. Cyclophilins are ubiquitously expressed proteins that bind to prolines and can catalyse cis/trans isomerization of proline residues. There are 17 annotated members of the cyclophilin family in hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd3c0b110411a06c0f8fa98d6b65448
https://doi.org/10.1042/bj20150396

Development of Fluorescent Substrates and Assays for the Key Autophagy-Related Cysteine Protease Enzyme, ATG4B

Autor: Tara L. Davis, Thanh G. Nguyen, Tom A. Pfeifer, Nicolette S. Honson, Nag S. Kumar, Robert N. Young, Suzana Kovacic, Sirano Dhe-Paganon, Steven Arns

Publikováno v: ASSAY and Drug Development Technologies. 12:176-189

The cysteine protease ATG4B plays a role in key steps of the autophagy process and is of interest as a potential therapeutic target. At an early step, ATG4B cleaves proLC3 isoforms to form LC3-I for subsequent lipidation to form LC3-II and autophagos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7075263ec315b65f948c6419b397552a
https://doi.org/10.1089/adt.2013.561

A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation

Autor: John R. Walker, Farell Mackenzie, Tara L. Davis, Leanne E. Wybenga-Groot, E.M. Newman, P.J. Finerty, Dene R. Littler, Sirano Dhe-Paganon

Publikováno v: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 66:143-151

The AMP-activated protein kinase (AMPK) is a highly conserved trimeric protein complex that is responsible for energy homeostasis in eukaryotic cells. Here, a 1.9 A resolution crystal structure of the isolated kinase domain from the alpha2 subunit of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7521215b13f1619933210d8c6d51f21b
https://doi.org/10.1107/s1744309109052543