Homeostatic regulation through strengthening of neuronal network-correlated synaptic inputs

Autor: Samuel J Barnes, Georg B Keller, Tara Keck

Publikováno v: eLife, Vol 11 (2022)

Homeostatic regulation is essential for stable neuronal function. Several synaptic mechanisms of homeostatic plasticity have been described, but the functional properties of synapses involved in homeostasis are unknown. We used longitudinal two-photo

Externí odkaz: https://doaj.org/article/1d5f71042f194154bd2a9221144e2f0f

Cre-dependent expression of multiple transgenes in isolated neurons of the adult forebrain.

Autor: Sridhara Chakravarthy, Tara Keck, Martijn Roelandse, Robin Hartman, Andreas Jeromin, Sean Perry, Sonja B Hofer, Thomas Mrsic-Flogel, Christiaan N Levelt

Publikováno v: PLoS ONE, Vol 3, Iss 8, p e3059 (2008)

BACKGROUND: Transgenic mice with mosaic, Golgi-staining-like expression of enhanced green fluorescent protein (EGFP) have been very useful in studying the dynamics of neuronal structure and function. In order to further investigate the molecular even

Externí odkaz: https://doaj.org/article/ccbb607fc0214fada44b0808bc118b74

The Ups and Downs of Firing Rate Homeostasis

Autor: Tara Keck, R. Irene Jacobsen

Publikováno v: Neuron. 109:401-403

Torrado Pacheco et al. demonstrate that downward firing rate homeostasis occurs when cellular activity levels increase beyond baseline, but only during sleep-dense periods. In contrast, Hebbian-facilitated changes in firing rate occur independently o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e8adcc543d9db892489f5b5273c814f
https://doi.org/10.1016/j.neuron.2020.12.024

Microglia Tweak Retinogeniculate Pathways during Visual Circuit Refinement

Autor: Tara Keck

Publikováno v: Neuron. 108:397-399

Cheadle et al. reveal that microglia expressing TWEAK facilitate synapse elimination through a novel, non-phagocytic mechanism in the retinogeniculate pathway during visual circuit development. This mechanism is experience-dependent and occurs throug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f9a2b5ba8cff07b5c8fcd503439990a
https://doi.org/10.1016/j.neuron.2020.10.018

Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions

Autor: Mark C. W. van Rossum, Frank Sengpiel, Tara Keck, Wulfram Gerstner, Lu Chen, Gina G. Turrigiano, John E. Lisman, Daniel E. Feldman, David Stellwagen, Hey Kyoung Lee, Taro Toyoizumi, Brent Doiron, Michael P. Stryker, Tobias Rose, Kevin Fox, Philip G. Haydon, Mark Hübener

Publikováno v: Keck, T, Toyoizumi, T, Chen, L, Doiron, B, Feldman, D E, Fox, K, Gerstner, W G, Haydon, P G, Hübener, M, Lee, H-K, Lisman, J E, Rose, T, Sengpiel, F, Stellwagen, D, Stryker, M P, Turrigiano, G G & Van Rossum, M 2017, ' Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions ', Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 372, no. 1715 . https://doi.org/10.1098/rstb.2016.0158
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, vol 372, iss 1715

We summarize here the results presented and subsequent discussion from the meeting on Integrating Hebbian and Homeostatic Plasticity at the Royal Society in April 2016. We first outline the major themes and results presented at the meeting. We next p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9af1060650111d6bcf973c21d67009
https://europepmc.org/articles/PMC5247590/