Lichen planopilaris associated with pembrolizumab in a patient with metastatic melanoma

Autor: Anna L. Cogen, MD, PhD, Vishwas Parekh, MD, Tara Gangadhar, MD, Jules B. Lipoff, MD

Publikováno v: JAAD Case Reports, Vol 4, Iss 2, Pp 132-134 (2018)

Externí odkaz: https://doaj.org/article/846261c497e843cb9e39b9a13abd7e4c

774 A phase 1 study exploring the safety and tolerability of the small molecule PD-L1 inhibitor, INCB086550, in patients with select advanced tumors

Autor: Christophe Le Tourneau, Sarina Piha-Paul, Hans Prenen, Brant Delafontaine, David Pinato, Armando Santoro, Rebecca Kristeleit, Kristen Spencer, Tara Gangadhar, Howard Burris, Nuria Kotecki, Bristi Basu, Donna Graham, Anna Maria Di Giacomo, Solmaz Sahebjam, Massimo Di Nicola, Carlos Gomez-Roca, Pascale Tomasini, Paolo Ascierto, Giuseppe Curigliano, Thomas Karasic, Ryan Geschwindt, Jeannie Daniel, Eric Van Cutsem

Publikováno v: Regular and Young Investigator Award Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c4900fe963b2edfe2b3b8842c3c02d6
https://doi.org/10.1136/jitc-2022-sitc2022.0774

First-in-human, phase I/IIa study of CRLX301, a nanoparticle drug conjugate containing docetaxel, in patients with advanced or metastatic solid malignancies

Autor: Sarina A, Piha-Paul, Kyaw Z, Thein, Paul, De Souza, Richard, Kefford, Tara, Gangadhar, Christopher, Smith, Shelly, Schuster, William C, Zamboni, Claire E, Dees, Ben, Markman

Publikováno v: Investigational new drugs. 39(4)

Background This was a phase I/IIa study to investigate the tolerability, efficacy and pharmacokinetics (PK)/ pharmacodynamics (PD) of CRLX301, CDP-based nanoparticle formulation of docetaxel. Methods The study was conducted in two parts. In part 1, d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::45d00f7dcbb7017406fa2044d6cade09
https://pubmed.ncbi.nlm.nih.gov/33594602

Adjuvant vemurafenib in resected, BRAF V600 mutation-positive melanoma (BRIM8): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial

Autor: Michele Maio, Karl Lewis, Lev Demidov, Mario Mandalà, Igor Bondarenko, Paolo A Ascierto, Christopher Herbert, Andrzej Mackiewicz, Piotr Rutkowski, Alexander Guminski, Grant R Goodman, Brian Simmons, Chenglin Ye, Yibing Yan, Dirk Schadendorf, Gabriela Cinat, Luis Enrique Fein, Michael Brown, Andrew Haydon, Adnan Khattak, Catriona McNeil, Phillip Parente, Jeremy Power, Rachel Roberts-Thomson, Shahneen Sandhu, Craig Underhill, Suresh Varma, Thomas Berger, Ahmad Awada, Nathalie Blockx, Veronique Buyse, Jeroen Mebis, Fábio André Franke, Sérgio Jobim de Azevedo, Nicolas Silva Lazaretti, Rahima Jamal, Catalin Mihalcioiu, Teresa Petrella, Kerry Savage, Xinni Song, Ralph Wong, Nina Dabelic, Stjepko Plestina, Zeljko Vojnovic, Petr Arenberger, Ivo Kocak, Ivana Krajsova, Eugen Kubala, Bohuslav Melichar, Yvetta Vantuchova, Kadri Putnik, Brigitte Dreno, Caroline Dutriaux, Jean-Jacques Grob, Pascal Joly, Jean-Philippe Lacour, Nicolas Meyer, Laurent Mortier, Luc Thomas, Michael Fluck, Thilo Gambichler, Jessica Hassel, Axel Hauschild, Paul Donnellan, John McCaffrey, Derek Power, Samuel Ariad, Gil Bar-Sela, Daniel Hendler, Ilan Ron, Jacob Schachter, Paolo Ascierto, Alfredo Berruti, Luca Bianchi, Vanna Chiarion Sileni, Francesco Cognetti, Riccardo Danielli, Anna Maria Di Giacomo, Luca Gianni, Aron Goldhirsch, Michele Guida, Paolo Marchetti, Paola Queirolo, Armando Santoro, Ellen Kapiteijn, Paula Ferreira, Georgy Gafton, Yulia Makarova, Zoran Andric, Nada Babovic, Darjana Jovanovic, Lidija Kandolf Sekulovic, Graham Cohen, Lydia Dreosti, Daniel Vorobiof, Maria Teresa Curiel Garcia, Roberto Diaz Beveridge, Margarita Majem Tarruella, Ivan Marquez Rodas, Jose-M Puliats Rodriguez, Antonio Rueda Dominguez, Marianne Maroti, Karin Papworth, Olivier Michielin, Ewan Brown, Pippa Corrie, Mark Harries, Satish Kumar, Agustin Martin-Clavijo, Mark Middleton, Poulam Patel, Toby Talbot, Sanjiv Agarwala, Paul Chapman, Robert Conry, Gary Doolittle, Tara Gangadhar, Sigrun Hallmeyer, Omid Hamid, Leonel Hernandez-Aya, Douglas Johnson, Frederic Kass, Tatjana Kolevska, Scott Lunin, April Salama, Branimir Sikic, Bradley Somer, David Spigel, Eric Whitman

Summary Background Systemic adjuvant treatment might mitigate the high risk of disease recurrence in patients with resected stage IIC–III melanoma. The BRIM8 study evaluated adjuvant vemurafenib monotherapy in patients with resected, BRAF V600 muta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ca377ad3c682462789b57095f06c16
http://hdl.handle.net/11379/501841

The role of chemokine receptor CXCR4 in lung cancer

Autor: Tara Gangadhar, Suvobroto Nandi, Ravi Salgia

Publikováno v: Cancer Biology & Therapy. 9:409-416

Lung cancer is the leading cause of cancer deaths worldwide. Small cell lung cancer (SCLC), which comprises 15% of all lung cancers, is almost exclusively due to smoking and is highly aggressive due to early widespread metastasis. While combination c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc36dfe1b4f171d5ca0aa9293b5fffcc
https://doi.org/10.4161/cbt.9.6.11233