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pro vyhledávání: '"Tara G. Thakurta"'
Autor:
Anita V. Kumar, Taewook Kang, Tara G. Thakurta, Celeste Ng, Aric N. Rogers, Martin R. Larsen, Louis R. Lapierre
Publikováno v:
Kumar, A V, Kang, T, Thakurta, T G, Ng, C, Rogers, A N, Larsen, M R & Lapierre, L R 2022, ' Exportin 1 modulates life span by regulating nucleolar dynamics via the autophagy protein LGG-1/GABARAP ', Science Advances, vol. 8, no. 13, eabj1604 . https://doi.org/10.1126/sciadv.abj1604
Altered nucleolar and ribosomal dynamics are key hallmarks of aging, but their regulation remains unclear. Building on the knowledge that the conserved nuclear export receptor Exportin 1 (XPO-1/XPO1) modulates proteostasis and life span, we systemati