Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Tara Fox"'
Autor:
Lorenzo I. Finci, Mayukh Chakrabarti, Gulcin Gulten, Joseph Finney, Carissa Grose, Tara Fox, Renbin Yang, Dwight V. Nissley, Frank McCormick, Dominic Esposito, Trent E. Balius, Dhirendra K. Simanshu
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract RAF kinases are integral to the RAS-MAPK signaling pathway, and proper RAF1 folding relies on its interaction with the chaperone HSP90 and the cochaperone CDC37. Understanding the intricate molecular interactions governing RAF1 folding is cr
Externí odkaz:
https://doaj.org/article/e615e38499a94c368dff4f9a7c76932e
Autor:
R. Matthew Hutchison, Karleyton C. Evans, Tara Fox, Minhua Yang, Jerome Barakos, Barry J. Bedell, Jesse M. Cedarbaum, Miroslaw Brys, Andrew Siderowf, Anthony E. Lang
Publikováno v:
BMC Neurology, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background Dopamine transporter single-photon emission computed tomography (DaT-SPECT) can quantify the functional integrity of the dopaminergic nerve terminals and has been suggested as an imaging modality to verify the clinical diagnosis o
Externí odkaz:
https://doaj.org/article/0488346b56e840c7bd83cdfb6e977f97
Autor:
Giuseppe Cimicata, Gil Fridkin, Tanaya Bose, Zohar Eyal, Yehuda Halfon, Elinor Breiner-Goldstein, Tara Fox, Ella Zimmerman, Anat Bashan, Natalia de Val, Alexander Wlodawer, Ada Yonath
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT The ribosome, a multicomponent assembly consisting of RNA and proteins, is a pivotal macromolecular machine that translates the genetic code into proteins. The large ribosomal subunit rRNA helix 68 (H68) is a key element in the protein synth
Externí odkaz:
https://doaj.org/article/d0fed25417f0439887632ec8537d4997
Autor:
Doreen Matthies, Chanhyung Bae, Gilman ES Toombes, Tara Fox, Alberto Bartesaghi, Sriram Subramaniam, Kenton Jon Swartz
Publikováno v:
eLife, Vol 7 (2018)
Voltage-activated potassium (Kv) channels open to conduct K+ ions in response to membrane depolarization, and subsequently enter non-conducting states through distinct mechanisms of inactivation. X-ray structures of detergent-solubilized Kv channels
Externí odkaz:
https://doaj.org/article/66eee0a717f34da399393babbf76f5ff
Autor:
Andrew Siderowf, Jerome Barakos, Tara Fox, Anthony E. Lang, R. Matthew Hutchison, Miroslaw Brys, Minhua Yang, Karleyton C. Evans, Barry J. Bedell, Jesse M. Cedarbaum
Publikováno v:
BMC Neurology, Vol 21, Iss 1, Pp 1-10 (2021)
BMC Neurology
BMC Neurology
Background Dopamine transporter single-photon emission computed tomography (DaT-SPECT) can quantify the functional integrity of the dopaminergic nerve terminals and has been suggested as an imaging modality to verify the clinical diagnosis of Parkins
Autor:
Anthony E, Lang, Andrew D, Siderowf, Eric A, Macklin, Werner, Poewe, David J, Brooks, Hubert H, Fernandez, Olivier, Rascol, Nir, Giladi, Fabrizio, Stocchi, Caroline M, Tanner, Ronald B, Postuma, David K, Simon, Eduardo, Tolosa, Brit, Mollenhauer, Jesse M, Cedarbaum, Kyle, Fraser, James, Xiao, Karleyton C, Evans, Danielle L, Graham, Inbal, Sapir, Jennifer, Inra, R Matthew, Hutchison, Minhua, Yang, Tara, Fox, Samantha, Budd Haeberlein, Tien, Dam, Laurice, Yang
Publikováno v:
Lang, A E, Siderowf, A D, Macklin, E A, Poewe, W, Brooks, D J, Fernandez, H H, Rascol, O, Giladi, N, Stocchi, F, Tanner, C M, Postuma, R B, Simon, D K, Tolosa, E, Mollenhauer, B, Cedarbaum, J M, Fraser, K, Xiao, J, Evans, K C, Graham, D L, Sapir, I, Inra, J, Hutchison, R M, Yang, M, Fox, T, Budd Haeberlein, S, Dam, T & SPARK Investigators 2022, ' Trial of Cinpanemab in Early Parkinson's Disease ', The New England Journal of Medicine, vol. 387, no. 5, pp. 408-420 . https://doi.org/10.1056/NEJMoa2203395
BACKGROUND: Aggregated α-synuclein plays an important role in Parkinson's disease pathogenesis. Cinpanemab, a human-derived monoclonal antibody that binds to α-synuclein, is being evaluated as a disease-modifying treatment for Parkinson's disease.
Publikováno v:
Nat Struct Mol Biol
The mitochondrial membrane-bound AAA protein Bcs1 translocate substrates across the mitochondrial inner membrane with-out previous unfolding. One substrate of Bcs1 is the iron–sulfur protein (ISP), a subunit of the respiratory Complex III. How Bcs1
Autor:
Jason Aldred, Natalia Penner, Pepinsky R Blake, Ira J. Goodman, Erica Koenig, Shavy Makh, Laura Fanning, Serena Hung, Andreas Weihofen, YuTing Liu, Minhua Yang, Danielle Graham, Eric David, Mackenzie Welch, Jesse M. Cedarbaum, Miroslaw Brys, Aaron Ellenbogen, Tara Fox
Publikováno v:
Movement Disorders
Background Pathological and genetic evidence implicates toxic effects of aggregated α‐synuclein in the pathophysiology of neuronal dysfunction and degeneration in Parkinson's disease. Immunotherapy targeting aggregated α‐synuclein is a promisin
Autor:
Xiang Xu, Martin Gellert, Jiansen Jiang, Joyce C. Cheung, Tara Fox, Xuemin Chen, Yun Chen, Natalia de Val, Huaibin Wang, Wei Yang
Phosphatidylinositol 3-kinase-related kinases (PIKKs) are composed of conserved FAT and kinase domains (FATKIN) along with varied solenoid structures made of HEAT repeats. These kinases are activated in response to cellular stress signals, but the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::befc0f68f4b405b12e4c009fe902350e
https://doi.org/10.1101/2020.10.19.346148
https://doi.org/10.1101/2020.10.19.346148
Autor:
Xuemin Chen, Xiang Xu, Martin Gellert, Yun Chen, Joyce C. Cheung, Tara Fox, Wei Yang, Jiansen Jiang, Natalia de Val, Huaibin Wang
Publikováno v:
Molecular cell. 81(4)
Summary DNA-dependent protein kinase (DNA-PK), like all phosphatidylinositol 3-kinase-related kinases (PIKKs), is composed of conserved FAT and kinase domains (FATKINs) along with solenoid structures made of HEAT repeats. These kinases are activated