Výsledky vyhledávání - "Tara E. Cusick"

Identification of an anabolic selective androgen receptor modulator that actively induces death of androgen-independent prostate cancer cells

Autor: William J. Ray, Chang Bai, Stephen E. Alves, Tara E. Cusick, Brenda L Pennypacker, Evan E. Opas, Michael J. Chisamore, Carlo J. Gambone, Damien Ferraro, David J. Bettoun, Azriel Schmidt, Hilary A. Wilkinson, Angela Scafonas, Michael A. Gentile, Osvaldo A. Flores, Paul Hodor, Meissner Robert S, James J. Perkins

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 143:29-39

Prostate cancer (PCa) initially responds to inhibition of androgen receptor (AR) signaling, but inevitably progresses to hormone ablation-resistant disease. Much effort is focused on optimizing this androgen deprivation strategy by improving hormone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05fa5f1d9ca8a07a5b1af5c4fa5cd5b
https://doi.org/10.1016/j.jsbmb.2014.02.005

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Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey

Autor: Tara E. Cusick, Brenda L Pennypacker, Le T. Duong, Donald B. Kimmel, Boyd B. Scott, Charles M Chen, Maureen Pickarski

Publikováno v: Journal of Bone and Mineral Research. 27:524-537

Odanacatib (ODN) is a selective and reversible inhibitor of cathepsin K (CatK). Previously, ODN was shown to increase bone mineral density (BMD) and maintained normal bone strength at the spine in ovariectomized (OVX) rhesus monkeys. Here, we further

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::501b038eb5689b37e823dfb777e14677
https://doi.org/10.1002/jbmr.1477

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Bone loss in the oestrogen-depleted rat is not exacerbated by sitagliptin, either alone or in combination with a thiazolidinedione

Autor: John E. Fisher, Helmut Glantschnig, Brenda L Pennypacker, K. R. Scott, Ronald B. Langdon, Tara E. Cusick, B. B. Zhang, Donald B. Kimmel, J. Mu, X. Shen, Z. Li

Publikováno v: Diabetes, obesitymetabolism. 15(10)

Antihyperglycaemic therapy on bone was evaluated in the ovariectomized (OVX), non-diabetic adult rat. Animals were treated daily for 12 weeks with various doses of sitagliptin, pioglitazone, rosiglitazone, combinations of sitagliptin with pioglitazon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2714c99345b9f0b7b6db5741004673b7
https://pubmed.ncbi.nlm.nih.gov/23551951

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