Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Tara Canonica"'
Autor:
Tara Canonica, Emma J. Kidd, Dorota Gibbins, Eva Lana-Elola, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Mark Good
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
BackgroundTrisomy of human chromosome 21 (Hsa21) results in a constellation of features known as Down syndrome (DS), the most common genetic form of intellectual disability. Hsa21 is orthologous to three regions in the mouse genome on mouse chromosom
Externí odkaz:
https://doaj.org/article/b395bf2008984e8eba2831c22e885ced
Autor:
Tara Canonica, Ioannis Zalachoras
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Motivated behavior is integral to the survival of individuals, continuously directing actions toward rewards or away from punishments. The orchestration of motivated behavior depends on interactions among different brain circuits, primarily within th
Externí odkaz:
https://doaj.org/article/8ca119f6e42f4d8dbc547280b400b45b
Autor:
Eva Lana-Elola, Heather Cater, Sheona Watson-Scales, Simon Greenaway, Jennifer Müller-Winkler, Dorota Gibbins, Mihaela Nemes, Amy Slender, Tertius Hough, Piia Keskivali-Bond, Cheryl L. Scudamore, Eleanor Herbert, Gareth T. Banks, Helene Mobbs, Tara Canonica, Justin Tosh, Suzanna Noy, Miriam Llorian, Patrick M. Nolan, Julian L. Griffin, Mark Good, Michelle Simon, Ann-Marie Mallon, Sara Wells, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 10 (2021)
Down syndrome (DS), trisomy 21, results in many complex phenotypes including cognitive deficits, heart defects and craniofacial alterations. Phenotypes arise from an extra copy of human chromosome 21 (Hsa21) genes. However, these dosage-sensitive cau
Externí odkaz:
https://doaj.org/article/2e0de4e621364f88bbb0ae2f68e17fe9
Autor:
Pishan Chang, Daniel Bush, Stephanie Schorge, Mark Good, Tara Canonica, Nathanael Shing, Suzanna Noy, Frances K. Wiseman, Neil Burgess, Victor L.J. Tybulewicz, Matthew C. Walker, Elizabeth M.C. Fisher
Publikováno v:
Cell Reports, Vol 30, Iss 4, Pp 1152-1163.e4 (2020)
Summary: Altered neural dynamics in the medial prefrontal cortex (mPFC) and hippocampus may contribute to cognitive impairments in the complex chromosomal disorder Down syndrome (DS). Here, we demonstrate non-overlapping behavioral differences associ
Externí odkaz:
https://doaj.org/article/0726a09e79f942f28afb7ca0608d677c
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Dopamine release from the ventral tegmental area (VTA) terminals in the primary motor cortex (M1) enables motor skill acquisition. Here, we test the hypothesis that dopaminergic VTA neurons projecting to M1 are activated when rewards are obt
Externí odkaz:
https://doaj.org/article/adf6700b3ede46c7972e497376821b2f
Autor:
Elizabeth M. C. Fisher, Suzanna Noy, Nathanael Shing, Stephanie Schorge, Daniel Bush, Victor L. J. Tybulewicz, Neil Burgess, Tara Canonica, Frances K. Wiseman, Mark Andrew Good, Pishan Chang, Matthew C. Walker
Publikováno v:
1163.e4
Cell Reports
Cell Reports, Vol 30, Iss 4, Pp 1152-1163.e4 (2020)
Cell Reports
Cell Reports, Vol 30, Iss 4, Pp 1152-1163.e4 (2020)
Summary Altered neural dynamics in the medial prefrontal cortex (mPFC) and hippocampus may contribute to cognitive impairments in the complex chromosomal disorder Down syndrome (DS). Here, we demonstrate non-overlapping behavioral differences associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5e6699f0a3da2804dd4e465cb08d89
http://hdl.handle.net/10044/1/76727
http://hdl.handle.net/10044/1/76727
