Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tara C, Mills"'
Autor:
John A. Lees, Bart Ferwerda, Philip H. C. Kremer, Nicole E. Wheeler, Mercedes Valls Serón, Nicholas J. Croucher, Rebecca A. Gladstone, Hester J. Bootsma, Nynke Y. Rots, Alienke J. Wijmega-Monsuur, Elisabeth A. M. Sanders, Krzysztof Trzciński, Anne L. Wyllie, Aeilko H. Zwinderman, Leonard H. van den Berg, Wouter van Rheenen, Jan H. Veldink, Zitta B. Harboe, Lene F. Lundbo, Lisette C. P. G. M. de Groot, Natasja M. van Schoor, Nathalie van der Velde, Lars H. Ängquist, Thorkild I. A. Sørensen, Ellen A. Nohr, Alexander J. Mentzer, Tara C. Mills, Julian C. Knight, Mignon du Plessis, Susan Nzenze, Jeffrey N. Weiser, Julian Parkhill, Shabir Madhi, Thomas Benfield, Anne von Gottberg, Arie van der Ende, Matthijs C. Brouwer, Jeffrey C. Barrett, Stephen D. Bentley, Diederik van de Beek
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specifi
Externí odkaz:
https://doaj.org/article/676c4fca20864aaa9d086a45a85f61c3
Autor:
James J. Gilchrist, Anna Rautanen, Benjamin P. Fairfax, Tara C. Mills, Vivek Naranbhai, Holly Trochet, Matti Pirinen, Esther Muthumbi, Salim Mwarumba, Patricia Njuguna, Neema Mturi, Chisomo L. Msefula, Esther N. Gondwe, Jenny M. MacLennan, Stephen J. Chapman, Malcolm E. Molyneux, Julian C. Knight, Chris C. A. Spencer, Thomas N. Williams, Calman A. MacLennan, J. Anthony G. Scott, Adrian V. S. Hill
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nontyphoidal Salmonella (NTS) is a major cause of bacteraemia in children and HIV-infected adults in Africa. Here, Gilchrist et al. conduct a genome-wide association study and show that genetic variation in STAT4 is a determinant of NTS in Kenyan and
Externí odkaz:
https://doaj.org/article/f39fdec2fbbb4ab0bac55463ac8b21f7
Autor:
Martin Forster, Joshua Savage, Dee Wherton, Yvonne Summers, Emilia L. Lim, P. Jain, James Spicer, Noelle O'Rourke, Alison Brewster, Thomas B.K. Watkins, Peter Fletcher, Tara C. Mills, Charles Swanton, David Gilligan, Sanjay Popat, Melanie Mackean, Maria Antonietta Cerone, Alastair Greystoke, Judith Cave, Lucinda Billingham, Manita Mehmi, Rowena Sharpe, Elizabeth Toy, Gary Middleton, Amanda Farley, Adam Dangoor, Timothy A. Yap
Publikováno v:
Nature
The majority of targeted therapies for non-small-cell lung cancer (NSCLC) are directed against oncogenic drivers that are more prevalent in patients with light exposure to tobacco smoke1–3. As this group represents around 20% of all patients with l
Autor:
Sunny H Wong, Sailesh Gochhait, Dheeraj Malhotra, Fredrik H Pettersson, Yik Y Teo, Chiea C Khor, Anna Rautanen, Stephen J Chapman, Tara C Mills, Amit Srivastava, Aleksey Rudko, Maxim B Freidin, Valery P Puzyrev, Shafat Ali, Shweta Aggarwal, Rupali Chopra, Belum S N Reddy, Vijay K Garg, Suchismita Roy, Sarah Meisner, Sunil K Hazra, Bibhuti Saha, Sian Floyd, Brendan J Keating, Cecilia Kim, Benjamin P Fairfax, Julian C Knight, Philip C Hill, Richard A Adegbola, Hakon Hakonarson, Paul E M Fine, Ramasamy M Pitchappan, Rameshwar N K Bamezai, Adrian V S Hill, Fredrik O Vannberg
Publikováno v:
PLoS Pathogens, Vol 6, p e1000979 (2010)
Leprosy is an infectious disease caused by the obligate intracellular pathogen Mycobacterium leprae and remains endemic in many parts of the world. Despite several major studies on susceptibility to leprosy, few genomic loci have been replicated inde
Externí odkaz:
https://doaj.org/article/64063bfbf0014cd68c02a3a26d68c81c
Autor:
Anne von Gottberg, Jan H. Veldink, Wouter van Rheenen, Nynke Y. Rots, Lars Ängquist, Anne L. Wyllie, Lisette C. P. G. M. de Groot, Hester J. Bootsma, Ellen A. Nohr, Lene Fogt Lundbo, Rebecca A. Gladstone, Susan A. Nzenze, Thomas Benfield, Aeilko H. Zwinderman, Julian C. Knight, Jeffrey N. Weiser, Krzysztof Trzciński, Nicholas J. Croucher, Shabir Madhi, Mignon du Plessis, Thorkild I. A. Sørensen, Tara C. Mills, Bart Ferwerda, Elisabeth A. M. Sanders, Nicole E. Wheeler, Diederik van de Beek, Philip H. C. Kremer, Jeffrey C. Barrett, Alexander J. Mentzer, Stephen D. Bentley, Matthijs C. Brouwer, Mercedes Valls Serón, Nathalie van der Velde, Alienke J. Wijmega-Monsuur, Leonard H. van den Berg, Arie van der Ende, Zitta Barrella Harboe, Natasja M. van Schoor, Julian Parkhill, John A. Lees
Publikováno v:
Nature Communications, 10:2176. Nature Publishing Group
Nature Communications 10 (2019) 1
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Lees, J A, Ferwerda, B, Kremer, P H C, Wheeler, N E, Serón, M V, Croucher, N J, Gladstone, R A, Bootsma, H J, Rots, N Y, Wijmega-Monsuur, A J, Sanders, E A M, Trzciński, K, Wyllie, A L, Zwinderman, A H, van den Berg, L H, van Rheenen, W, Veldink, J H, Harboe, Z B, Lundbo, L F, de Groot, L C P G M, van Schoor, N M, van der Velde, N, Ängquist, L H, Sørensen, T I A, Nohr, E A, Mentzer, A J, Mills, T C, Knight, J C, du Plessis, M, Nzenze, S, Weiser, J N, Parkhill, J, Madhi, S, Benfield, T, von Gottberg, A, van der Ende, A, Brouwer, M C, Barrett, J C, Bentley, S D & van de Beek, D 2019, ' Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis ', Nature Communications, vol. 10, 2176 . https://doi.org/10.1038/s41467-019-09976-3
Lees, J A, Ferwerda, B, Kremer, P H C, Wheeler, N E, Seron, M V, Croucher, N J, Gladstone, R A, Bootsma, H J, Rots, N Y, Wijmega-Monsuur, A J, Sanders, E A M, Trzcinski, K, Wyllie, A L, Zwinderman, A H, van den Berg, L H, van Rheenen, W, Veldink, J H, Harboe, Z B, Lundbo, L F, de Groot, L C P G M, van Schoor, N M, van der Velde, N, Angquist, L H, Sørensen, T I A, Nohr, E A, Mentzer, A J, Mills, T C, Knight, J C, du Plessis, M, Nzenze, S, Weiser, J N, Parkhill, J, Madhi, S, Benfield, T, von Gottberg, A, van der Ende, A, Brouwer, M C, Barrett, J C, Bentley, S D & van de Beek, D 2019, ' Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis ', Nature Communications, vol. 10, 2176 . https://doi.org/10.1038/s41467-019-09976-3
Nature Communications, 10(1):2176. Nature Publishing Group UK
Nature Communications
Nature communications, 10(1):2176. Nature Publishing Group
Lees, J A, Ferwerda, B, Kremer, P H C, Wheeler, N E, Serón, M V, Croucher, N J, Gladstone, R A, Bootsma, H J, Rots, N Y, Wijmega-Monsuur, A J, Sanders, E A M, Trzciński, K, Wyllie, A L, Zwinderman, A H, van den Berg, L H, van Rheenen, W, Veldink, J H, Harboe, Z B, Lundbo, L F, de Groot, L C P G M, van Schoor, N M, van der Velde, N, Ängquist, L H, Sørensen, T I A, Nohr, E A, Mentzer, A J, Mills, T C, Knight, J C, du Plessis, M, Nzenze, S, Weiser, J N, Parkhill, J, Madhi, S, Benfield, T, von Gottberg, A, van der Ende, A, Brouwer, M C, Barrett, J C, Bentley, S D & van de Beek, D 2019, ' Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis ', Nature Communications, vol. 10, no. 1, 2176 . https://doi.org/10.1038/s41467-019-09976-3
Nature Communications, 10(1)
Nature Communications 10 (2019) 1
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Lees, J A, Ferwerda, B, Kremer, P H C, Wheeler, N E, Serón, M V, Croucher, N J, Gladstone, R A, Bootsma, H J, Rots, N Y, Wijmega-Monsuur, A J, Sanders, E A M, Trzciński, K, Wyllie, A L, Zwinderman, A H, van den Berg, L H, van Rheenen, W, Veldink, J H, Harboe, Z B, Lundbo, L F, de Groot, L C P G M, van Schoor, N M, van der Velde, N, Ängquist, L H, Sørensen, T I A, Nohr, E A, Mentzer, A J, Mills, T C, Knight, J C, du Plessis, M, Nzenze, S, Weiser, J N, Parkhill, J, Madhi, S, Benfield, T, von Gottberg, A, van der Ende, A, Brouwer, M C, Barrett, J C, Bentley, S D & van de Beek, D 2019, ' Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis ', Nature Communications, vol. 10, 2176 . https://doi.org/10.1038/s41467-019-09976-3
Lees, J A, Ferwerda, B, Kremer, P H C, Wheeler, N E, Seron, M V, Croucher, N J, Gladstone, R A, Bootsma, H J, Rots, N Y, Wijmega-Monsuur, A J, Sanders, E A M, Trzcinski, K, Wyllie, A L, Zwinderman, A H, van den Berg, L H, van Rheenen, W, Veldink, J H, Harboe, Z B, Lundbo, L F, de Groot, L C P G M, van Schoor, N M, van der Velde, N, Angquist, L H, Sørensen, T I A, Nohr, E A, Mentzer, A J, Mills, T C, Knight, J C, du Plessis, M, Nzenze, S, Weiser, J N, Parkhill, J, Madhi, S, Benfield, T, von Gottberg, A, van der Ende, A, Brouwer, M C, Barrett, J C, Bentley, S D & van de Beek, D 2019, ' Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis ', Nature Communications, vol. 10, 2176 . https://doi.org/10.1038/s41467-019-09976-3
Nature Communications, 10(1):2176. Nature Publishing Group UK
Nature Communications
Nature communications, 10(1):2176. Nature Publishing Group
Lees, J A, Ferwerda, B, Kremer, P H C, Wheeler, N E, Serón, M V, Croucher, N J, Gladstone, R A, Bootsma, H J, Rots, N Y, Wijmega-Monsuur, A J, Sanders, E A M, Trzciński, K, Wyllie, A L, Zwinderman, A H, van den Berg, L H, van Rheenen, W, Veldink, J H, Harboe, Z B, Lundbo, L F, de Groot, L C P G M, van Schoor, N M, van der Velde, N, Ängquist, L H, Sørensen, T I A, Nohr, E A, Mentzer, A J, Mills, T C, Knight, J C, du Plessis, M, Nzenze, S, Weiser, J N, Parkhill, J, Madhi, S, Benfield, T, von Gottberg, A, van der Ende, A, Brouwer, M C, Barrett, J C, Bentley, S D & van de Beek, D 2019, ' Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis ', Nature Communications, vol. 10, no. 1, 2176 . https://doi.org/10.1038/s41467-019-09976-3
Nature Communications, 10(1)
Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee6d7584fa83d9ebe796545bc02603c
https://www.repository.cam.ac.uk/handle/1810/294917
https://www.repository.cam.ac.uk/handle/1810/294917
Autor:
Thomas B.K. Watkins, Amanda Farley, Maria Antonietta Cerone, Martin Forster, Alison Brewster, Adam Dangoor, Peter Fletcher, Melanie Mackean, David Gilligan, Elizabeth Toy, Sanjay Popat, Gary Middleton, Rowena Sharpe, Joshua Savage, Alastair Greystoke, James Spicer, Dee Wherton, Yvonne Summers, Noelle O'Rourke, Tara C. Mills, Judith Cave, Timothy A. Yap, Emilia L. Lim, P. Jain, Charles Swanton, Lucinda Billingham, Manita Mehmi
Publikováno v:
Nature. 585:E21-E21
Autor:
Nynke Y. Rots, Ellen A. Nohr, Lene Fogt Lundbo, Julian C. Knight, Mercedes Valls Serón, Mignon du Plessis, Tara C. Mills, Susan A. Nzenze, Jeffrey C. Barrett, Lisette C. P. G. M. de Groot, Thorkild I. A. Sørensen, Julian Parkhill, Bart Ferwerda, Matthijs C. Brouwer, Aeilko H. Zwinderman, Arie van der Ende, Stephen D. Bentley, Wouter van Rheenen, Zitta Barrella Harboe, Anne L. Wyllie, Elisabeth A. M. Sanders, Natasja M. van Schoor, Shabir Madhi, Jan H. Veldink, Nicholas J. Croucher, Anne von Gottberg, Hester J. Bootsma, Diederik van de Beek, Krzysztof Trzciński, Alexander J. Mentzer, Lars Ängquist, Rebecca A. Gladstone, John A. Lees, Nathalie van der Velde, Leonard H. van den Berg, Nicole E. Wheeler, Jeffrey N. Weiser, Philip H. C. Kremer, Thomas Benfield, Alienke J. Wijmega-Monsuur
Publikováno v:
SSRN Electronic Journal.
Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause lifethreatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal di
Autor:
Julie George, Precious G. Motshwene, Hui Wang, Andriy V. Kubarenko, Anna Rautanen, Tara C. Mills, Adrian V.S. Hill, Nicholas J. Gay, Alexander N.R. Weber
Publikováno v:
The Journal of Biological Chemistry
Innate immune receptors detect microbial pathogens and subsequently activate adaptive immune responses to combat pathogen invasion. MyD88 is a key adaptor molecule in both Toll-like receptor (TLR) and IL-1 receptor superfamily signaling pathways. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8a2f45c864104d16428a0b73062e93
https://ora.ox.ac.uk/objects/uuid:c3ebc1c8-34e5-4a10-bb6f-1bb0dcf69089
https://ora.ox.ac.uk/objects/uuid:c3ebc1c8-34e5-4a10-bb6f-1bb0dcf69089
Autor:
Julie George, Alexander N.R. Weber, Adrian V. S. Hill, Elif Colak, Tore Kempf, Tara C. Mills, Alexandra Nieters, Anna Rautanen, Andriy V. Kubarenko
Publikováno v:
The Journal of Immunology. 184:3025-3032
Signals elicited by TLRs following the detection of microbes are integrated and diversified by a group of four cytoplasmic adaptor molecules featuring an evolutionarily conserved Toll/IL-1R signaling domain. Single nucleotide polymorphisms (SNPs) in
Autor:
Tara C, Mills, Stephen, Chapman, Paula, Hutton, Anthony C, Gordon, Julian, Bion, Jean-Daniel, Chiche, Paul A H, Holloway, Frank, Stüber, Chris S, Garrard, Charles J, Hinds, Adrian V S, Hill, Anna, Rautanen
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 61(5)
Sepsis is an increasingly common condition, which continues to be associated with unacceptably high mortality. A large number of association studies have investigated susceptibility to, or mortality from, sepsis for variants in the functionally impor