How a paramyxovirus fusion/entry complex adapts to escape a neutralizing antibody

Autor: Tara C. Marcink, Gillian Zipursky, Elizabeth B. Sobolik, Kate Golub, Emily Herman, Kyle Stearns, Alexander L. Greninger, Matteo Porotto, Anne Moscona

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Paramyxoviruses including measles, Nipah, and parainfluenza viruses are public health threats with pandemic potential. Human parainfluenza virus type 3 (HPIV3) is a leading cause of illness in pediatric, older, and immunocompromised populati

Externí odkaz: https://doaj.org/article/d6338bf3d6fc4f57af5e347e7d359d1a

Subnanometer structure of an enveloped virus fusion complex on viral surface reveals new entry mechanisms

Autor: Tara C. Marcink, Gillian Zipursky, Wenjing Cheng, Kyle Stearns, Shari Stenglein, Kate Golub, Frances Cohen, Francesca Bovier, Daniel Pfalmer, Alexander L. Greninger, Matteo Porotto, Amedee des Georges, Anne Moscona

Publikováno v: Science Advances. 9

Paramyxoviruses—including important pathogens like parainfluenza, measles, and Nipah viruses—use a receptor binding protein [hemagglutinin-neuraminidase (HN) for parainfluenza] and a fusion protein (F), acting in a complex, to enter cells. We use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::505d1332c138a791a34b82c396aa7528
https://doi.org/10.1126/sciadv.ade2727

Intermediates in SARS-CoV-2 spike-mediated cell entry

Autor: Tara C. Marcink, Thomas Kicmal, Emily Armbruster, Zhening Zhang, Gillian Zipursky, Kate L. Golub, Mohab Idris, Jonathan Khao, Jennifer Drew-Bear, Gael McGill, Tom Gallagher, Matteo Porotto, Amédée des Georges, Anne Moscona

Publikováno v: Science advances. 8(33)

SARS-CoV-2 cell entry is completed after viral spike (S) protein–mediated membrane fusion between viral and host cell membranes. Stable prefusion and postfusion S structures have been resolved by cryo–electron microscopy and cryo–electron tomog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c0dd7eb0cf7e1adfe8f67a97eb05eb
https://pubmed.ncbi.nlm.nih.gov/35984891

Single-chain variable fragment antibody constructs neutralize measles virus infection in vitro and in vivo

Autor: Fabrizio Angius, Branka Horvat, Stefan Niewiesk, Anne Moscona, Marion Ferren, Olivia Harder, Jennifer Drew-Bear, Tara C. Marcink, Matteo Porotto, N. Valerio Dorrello, Camilla Predella, Cyrille Mathieu, Francesca T. Bovier, Alexander L. Greninger

Publikováno v: Cellular and molecular immunology
Cellular and molecular immunology, 2021, 18 (7), pp.1835-1837. ⟨10.1038/s41423-021-00691-y⟩
Cellular and molecular immunology, Nature Publishing Group/Chinese Society of Immunology, 2021, 18 (7), pp.1835-1837. ⟨10.1038/s41423-021-00691-y⟩
Cell Mol Immunol

International audience; No abstract available

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b42d895e56e35d7e381fbaf340f246
https://doi.org/10.1038/s41423-021-00691-y

Human parainfluenza virus evolution during lung infection of immunocompromised individuals promotes viral persistence

Autor: Shana R Burstein, Bert K. Rima, Jennifer Drew-Bear, Stefan Niewiesk, Michael Boeckh, Tara C. Marcink, Olivia Harder, Alexander L. Greninger, Michelle J. Lin, Matteo Porotto, Ksenia Rybkina, Ryan C. Shean, Negar Makhsous, Anne Moscona, Francesca T. Bovier

Publikováno v: J Clin Invest

The capacity of respiratory viruses to undergo evolution within the respiratory tract raises the possibility of evolution under the selective pressure of the host environment or drug treatment. Long-term infections in immunocompromised hosts are pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::addc80399323f0d5e2811a23bc1f5735
https://pubmed.ncbi.nlm.nih.gov/34609969