Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Tara B. Hendry-Hofer"'
Autor:
Jason R. Nielson, Anjali K. Nath, Kim P. Doane, Xu Shi, Jangwoen Lee, Emily G. Tippetts, Kusumika Saha, Jordan Morningstar, Kevin G. Hicks, Adriano Chan, Yanbin Zhao, Amy Kelly, Tara B. Hendry-Hofer, Alyssa Witeof, Patrick Y. Sips, Sari Mahon, Vikhyat S. Bebarta, Vincent Jo Davisson, Gerry R. Boss, Jared Rutter, Calum A. MacRae, Matthew Brenner, Robert E. Gerszten, Randall T. Peterson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Although cyanide’s biological effects are pleiotropic, its most obvious effects are as a metabolic poison. Cyanide potently inhibits cytochrome c oxidase and potentially other metabolic enzymes, thereby unleashing a cascade of metabolic pe
Externí odkaz:
https://doaj.org/article/cb54f482aaef485c9442a4f1d31f3076
Autor:
Vik S Bebarta, Xu Shi, Shunning Zheng, Tara B Hendry-Hofer, Carter C Severance, Matthew M Behymer, Gerry R Boss, Sari Mahon, Matthew Brenner, Gregory T Knipp, Vincent Jo Davisson, Randall T Peterson, Calum A MacRae, Jared Rutter, Robert E Gerszten, Anjali K Nath
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology, vol 191, iss 1
Cyanide—a fast-acting poison—is easy to obtain given its widespread use in manufacturing industries. It is a high-threat chemical agent that poses a risk of occupational exposure in addition to being a terrorist agent. FDA-approved cyanide antido
Autor:
Diane M Hildenberger, Patrick Ng, Kirsten Soules, Jessica N. Winborn, Brian A. Logue, Vikhyat S. Bebarta, Dennean S. Lippner, Melissa O Rhoomes, Gary A. Rockwood, Carter C Severance, Tara B. Hendry-Hofer, Subrata Bhadra
Publikováno v:
Clinical Toxicology. 60:95-101
Cyanide is a rapid acting, lethal, metabolic poison and remains a significant threat. Current FDA-approved antidotes are not amenable or efficient enough for a mass casualty incident.The objective of this study is to evaluate short and long-term effi
Autor:
Nicole L. Rumian, Carolyn Nicole Brown, Tara B. Hendry-Hofer, Thomas Rossetti, James E. Orfila, Jonathan E. Tullis, Linda P. Dwoskin, Olivia R. Buonarati, John E. Lisman, Nidia Quillinan, Paco S. Herson, Vikhyat S. Bebarta, K. Ulrich Bayer
Publikováno v:
Journal of Biological Chemistry. 299:104693
Autor:
Alison M. McGrath, Patrick Ng, Sari B. Mahon, Matthew Brenner, Gerry R. Boss, Joseph K. Maddry, David Mukai, Vikhyat S. Bebarta, Tara B. Hendry-Hofer
Publikováno v:
Annals of the New York Academy of Sciences. 1479:159-167
Hydrogen sulfide (H2 S), a high-threat chemical agent, occurs naturally in a variety of settings. Despite multiple incidents of exposures and deaths, no FDA-approved antidote exists. A rapid-acting, easy to administer antidote is needed. We conducted
Autor:
Matthew Brenner, Tara B. Hendry-Hofer, Vikhyat S. Bebarta, Patrick Ng, Sari B. Mahon, Gerry R. Boss, Alyssa E. Witeof
Publikováno v:
Annals of Emergency Medicine. 74:423-429
Study objective Cyanide is a deadly poison, particularly with oral exposure, in which larger doses can occur before any symptoms develop. Multiple governmental agencies highlight oral cyanide as an agent that can be used in a terrorist attack because
Autor:
Subrata, Bhadra, Adriano, Chan, Tara B, Hendry-Hofer, Gerry R, Boss, Vikhyat S, Bebarta, Brian A, Logue
Publikováno v:
Journal of Chromatography B. 1208:123392
Cyanide, hydrogen sulfide, and methanethiol are common toxic inhalation agents that inhibit mitochondrial cytochrome c oxidase and result in cellular hypoxia, cytotoxic anoxia, apnea, respiratory failure, cardiovascular collapse, seizure and potentia
Autor:
Tara B. Hendry-Hofer, Subrata Bhadra, Adriano Chan, Sari B. Mahon, Matthew Brenner, Jangwoen Lee, Gerry R. Boss, Renate B. Pilz, Nesta Bortey-Sam, Brian A. Logue, Vikhyat S. Bebarta
Publikováno v:
Clin Toxicol (Phila)
Clinical toxicology (Philadelphia, Pa.), vol 60, iss 3
Clinical toxicology (Philadelphia, Pa.), vol 60, iss 3
ContextHydrogen cyanide and methanethiol are two toxic gases that inhibit mitochondrial cytochrome c oxidase. Cyanide is generated in structural fires and methanethiol is released by decaying organic matter. Current treatments for cyanide exposure do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee8add4cc1470c4d7305ee4d92fefa0
https://europepmc.org/articles/PMC8800944/
https://europepmc.org/articles/PMC8800944/
Autor:
Robert E. Gerszten, Jangwoen Lee, Vikhyat S. Bebarta, Tara B. Hendry-Hofer, Gregg Knipp, Alyssa E. Witeof, Matthew Brenner, Calum A. MacRae, Sari B. Mahon, L. Tiffany Lyle, Randall T. Peterson, Gerry R. Boss, Vincent Jo Davisson, Anjali K. Nath, Jordan Morningstar
Publikováno v:
FASEB BioAdvances. 1:81-92
Cyanide is a highly toxic industrial chemical that is widely used by manufactures. Smoke inhalation during household fires is the most common source of cyanide poisoning while additional risks to civilians include industrial accidents and terrorist a
Autor:
Gary A. Rockwood, Alyssa E. Witeof, Sari B. Mahon, Vikhyat S. Bebarta, Dennean S. Lippner, Tara B. Hendry-Hofer, Matthew Brenner, Patrick Ng
Publikováno v:
Clinical toxicology (Philadelphia, Pa.), vol 57, iss 4
BACKGROUND: Cyanide is a deadly compound used as a terrorist agent. Current FDA approved antidotes require intravenous administration, limiting their utility in a mass casualty scenario. Dimethyl trisulfide (DMTS), a sulfur-based molecule, binds cyan