Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tara A. Peterson"'
Publikováno v:
Marine Drugs, Vol 21, Iss 12, p 642 (2023)
Cancer cells grown in 3D spheroid cultures are considered more predictive for clinical efficacy. The marine natural product dragmacidin D induces apoptosis in MDA-MB-231 and MDA-MB-468 triple-negative breast cancer (TNBC) spheroids within 24 h of tre
Externí odkaz:
https://doaj.org/article/24f1d13d4f1b4fe682ec2fc6a08a4435
Autor:
Esther A. Guzmán, Tara A. Peterson, Priscilla L. Winder, Kirstie T. Francis, Malcolm McFarland, Jill C. Roberts, Jennifer Sandle, Amy E. Wright
Publikováno v:
Toxins, Vol 15, Iss 11, p 664 (2023)
The Indian River Lagoon (IRL), a 156-mile-long estuary located on the eastern coast of Florida, experiences phytoplankton bloom events due to increased seasonal temperatures coupled with anthropogenic impacts. This study aimed to gather data on the t
Externí odkaz:
https://doaj.org/article/9629e742298b4f93a4fa8839e59ec041
Autor:
Rachel M. Bone Relat, Priscilla L. Winder, Gregory D. Bowden, Esther A. Guzmán, Tara A. Peterson, Shirley A. Pomponi, Jill C. Roberts, Amy E. Wright, Roberta M. O’Connor
Publikováno v:
Marine Drugs, Vol 20, Iss 4, p 240 (2022)
Cryptosporidium sp. are apicomplexan parasites that cause significant morbidity and possible mortality in humans and valuable livestock. There are no drugs on the market that are effective in the population most severely affected by this parasite. Th
Externí odkaz:
https://doaj.org/article/2ff3708d01bc44f6b72b3926946bfec2
Autor:
Tara S. Peterson, Megan E. Roth, James S. Hodges, Sean R. Landman, Kenneth B. Beckman, Morgan E. Meissner, Louis M. Mansky, Jonathan M.O. Rawson, Daryl M. Gohl
Publikováno v:
Journal of Molecular Biology. 429:2290-2307
A long-standing question of human immunodeficiency virus (HIV) genetic variation and evolution has been whether differences exist in mutation rate and/or mutation spectra among HIV types (i.e., HIV-1 versus HIV-2) and among HIV groups (i.e., HIV-1 gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83e1b41a7e5fe0b442e00640b5e1c01
https://doi.org/10.1016/j.jmb.2017.05.010
https://doi.org/10.1016/j.jmb.2017.05.010
Autor:
Joseph M. Luettgen, Carol A. Watson, Pancras C. Wong, Cailan Wang, Mark R. Harpel, Vidhyashankar Ramamurthy, Ge Zhang, Jeffrey M. Bozarth, Tara L. Peterson, Francis J. Woerner, Dietmar A. Seiffert, Alan R. Rendina, Frank A. Barbera, Karen A. Rossi, Ruth R. Wexler, Randi L. Brown, Joanne M. Smallheer, Paul E. Morin, Mimi L. Quan, Anzhi Wei
Publikováno v:
Journal of Medicinal Chemistry. 57:955-969
Antithrombotic agents that are inhibitors of factor XIa (FXIa) have the potential to demonstrate robust efficacy with a low bleeding risk profile. Herein, we describe a series of tetrahydroquinoline (THQ) derivatives as FXIa inhibitors. Compound 1 wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bee2063c9a736322e523829d9e9043e
https://doi.org/10.1021/jm401670x
https://doi.org/10.1021/jm401670x
Autor:
James A. Johnson, Ramakrishna Seethala, Christine Huang, Michael M. Miller, David S. Taylor, Ji Jiang, Ruth R. Wexler, Mark E. Salvati, Jun Zhang, Xiaohong Yin, Yalei Liu, R. Michael Lawrence, Tatyana Zvyaga, David S. Nirschl, Lalgudi S. Harikrishnan, Tara L. Peterson, Michael A. Poss, Alice Ye A. Chen, Leonard P. Adam, Yufeng Wang, Muthoni G. Kamau
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(20)
A novel series of diphenylpyridylethanamine-based inhibitors of cholesteryl ester transfer protein is described. Optimization of the urea moiety, particularly by incorporation of fluorine, is explored to balance in vitro metabolic stability with CETP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16e77fe68cebfc91bb03f93c0c149e1
https://pubmed.ncbi.nlm.nih.gov/22995620
https://pubmed.ncbi.nlm.nih.gov/22995620
Autor:
R. Michael Lawrence, George C. Morton, Mark E. Salvati, Jonathan O’Connell, Ramakrishna Seethala, Arthur V. Miller, Tara L. Peterson, Cooper Christopher B, Carolyn A. Weigelt, Yalei Liu, Tammy C. Wang, Lalgudi S. Harikrishnan, Timothy F. Herpin, Kingsley K. Appiah, David S. Taylor, Xiaohong Yin, Muthoni G. Kamau, Jennifer X. Qiao, Leonard P. Adam, Alice Ye A. Chen, David S. Nirschl
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(8)
2-Arylbenzoxazole 5 was identified as a hit from a fluorescence-based high-throughput screen for CETP inhibitors. The synthesis and SAR investigation employing array synthesis of the A- and B-rings are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cb06dc4861759c7d2f7f37b9fbbffa
https://pubmed.ncbi.nlm.nih.gov/18374566
https://pubmed.ncbi.nlm.nih.gov/18374566
Autor:
Andrew T. Pudzianowski, William A. Schumacher, Jeffrey M. Bozarth, Karnail S. Atwal, Doree F. Sitkoff, Thomas E. Steinbacher, Sharon N. Bisaha, Chi Li, Eddie C.-K. Liu, Sonia Youssef, Yan Shi, Philip D. Stein, Tara L. Peterson, Karen S. Hartl, Stephen P. O'connor, Ge Zhang, Mengxiao Shi, Steven M. Seiler, Jing Zhang, Robert Zahler, Gregory S. Bisacchi, Alan R. Rendina
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(24)
N,N'-Disubstituted ketene aminals are good bioisosteres of thiourea functional groups. We report the design and synthesis of a novel class of ketene aminal-based lactam derivatives as potent and orally active FXa inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19f39386a7d93483c0c1aba1fe06558
https://pubmed.ncbi.nlm.nih.gov/16213711
https://pubmed.ncbi.nlm.nih.gov/16213711
Autor:
Karen S. Hartl, Jeffrey M. Bozarth, Steven M. Seiler, Karnail S. Atwal, Chi Li, Sharon N. Bisaha, Thomas E. Steinbacher, Philip D. Stein, Yan Shi, Stephen P. O'connor, Andrew T. Pudzianowski, William A. Schumacher, Gregory S. Bisacchi, Doree F. Sitkoff, Alan R. Rendina, Eddie C.-K. Liu, Tara L. Peterson, Sonia Youssef, Ge Zhang, Mengxiao Shi, Jing Zhang, Robert Zahler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1449
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e89a71ee5433391287cf4ccdeff6d501
https://doi.org/10.1016/j.bmcl.2005.12.023
https://doi.org/10.1016/j.bmcl.2005.12.023