Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tapiwanashe Magwere"'
Autor:
Tapiwanashe Magwere, Susan A Burchill
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28558 (2011)
Glutathione (GSH) is implicated in drug resistance mechanisms of several cancers and is a key regulator of cell death pathways within cells. We studied Ewing's sarcoma family of tumours (ESFT) cell lines and three mechanistically distinct anticancer
Externí odkaz:
https://doaj.org/article/4fea49c96d7f4b2c9f2a29a3df77c0e2
Publikováno v:
Expert Review of Anticancer Therapy. 11:229-249
Reactive oxygen species (ROS) are highly reactive by-products of energy production that can have detrimental as well as beneficial effects. Unchecked, high levels of ROS result in an imbalance of cellular redox state and oxidative stress. High levels
Autor:
Martin D. Brand, Reinald Pamplona, Adrian J. Lambert, Jake Jacobson, Satomi Miwa, Tapiwanashe Magwere, Linda Partridge, Yasmine Driege, Manuel Portero-Otin
Publikováno v:
Aging Cell. 9:466-477
Low environmental temperature and dietary restriction (DR) extend lifespan in diverse organisms. In the fruit fly Drosophila, switching flies between temperatures alters the rate at which mortality subsequently increases with age but does not reverse
Publikováno v:
European Journal of Cancer. 44:2276-2287
Ewing's sarcoma family of tumours (ESFT) are childhood cancers whose aggressive behaviour and propensity to relapse prompts the need for new treatment approaches. In this study, the role of cellular antioxidants in determining the sensitivity of ESFT
Autor:
Steve Goodall, Linda Partridge, Martin D. Brand, William B. Mair, Tapiwanashe Magwere, Jeremy Skepper
Publikováno v:
Scopus-Elsevier
Dietary restriction (DR) extends life span in diverse organisms and may do so by attenuating production of mitochondrial reactive oxygen species (ROS). However, measurements of ROS production from isolated mitochondria of organisms subjected to DR ha
Publikováno v:
Free Radical Biology and Medicine. 22:321-327
The effect of chloroquine (CHQ) administration on antioxidant enzymes in rat liver and kidney was studied. Male Sprague-Dawley rats were administered 20 mg/kg CHQ once a week for 4 weeks (chronic treatment) or a single dose at 10 or 20 mg/kg (acute t
Autor:
Tapiwanashe Magwere
Human pancreatic carcinoma is a highly malignant cancer. Previous studies have shown that the decoy receptor 3 (DcR3) for Fas ligand (FasL) plays significant roles in tumour progression and immune suppression. In the present study, we evaluated the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fccf56301d1f7ffe5ad13eebd0489b97
https://europepmc.org/articles/PMC2743835/
https://europepmc.org/articles/PMC2743835/
Autor:
Ross G, Cooper, Tapiwanashe, Magwere
Publikováno v:
African health sciences. 7(3)
Chloroquine (CHQ), an antimalarial, is also used as an anti-inflammatory drug for systemic lupus erythematosus and rheumatoid arthritis (RA). Hydroxychloroquine (HCQ) reduces the frequency of organ involvement and disease flares, and relieves skin an
Autor:
Linda Partridge, Tapiwanashe Magwere, Melanie West, Kumars Riyahi, Michael P. Murphy, Robin A.J. Smith
Publikováno v:
Mechanisms of ageing and development. 127(4)
We used the fruit fly Drosophila melanogaster to test the effects of feeding the superoxide dismutase (SOD) mimetic drugs Euk-8 and -134 and the mitochondria-targeted mitoquinone (MitoQ) on lifespan and oxidative stress resistance of wild type and SO
Publikováno v:
The journals of gerontology. Series A, Biological sciences and medical sciences. 59(1)
Dietary restriction (DR) has been shown to increase life span in taxonomically diverse animal species. In this study we tested for sex differences in the response of life span to graded severity of DR in Drosophila melanogaster. In both sexes, life s