Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Tapesh Santra"'
Autor:
Nupur Mukherjee, Alacoque Browne, Laura Ivers, Tapesh Santra, Mattia Cremona, Bryan T. Hennessy, Norma O’Donovan, John Crown, Walter Kolch, Dirk Fey, Alex J. Eustace
Publikováno v:
Journal of Personalized Medicine, Vol 12, Iss 8, p 1277 (2022)
Triple negative breast cancer (TNBC) remains a therapeutic challenge due to the lack of targetable genetic alterations and the frequent development of resistance to the standard cisplatin-based chemotherapies. Here, we have taken a systems biology ap
Externí odkaz:
https://doaj.org/article/3d2a12f29f2f44e78dc4c41944a3e9ee
Autor:
Tapesh Santra, Ana Herrero, Javier Rodriguez, Alex von Kriegsheim, Luis F. Iglesias-Martinez, Thomas Schwarzl, Des Higgins, Thin-Thin Aye, Albert J.R. Heck, Fernando Calvo, Lorena Agudo-Ibáñez, Piero Crespo, David Matallanas, Walter Kolch
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 3100-3115.e7 (2019)
Summary: Modern omics technologies allow us to obtain global information on different types of biological networks. However, integrating these different types of analyses into a coherent framework for a comprehensive biological interpretation remains
Externí odkaz:
https://doaj.org/article/27f030445e9a4cbe8d263125c8df11ff
Autor:
Tapesh Santra, Sandra Roche, Neil Conlon, Norma O'Donovan, John Crown, Robert O'Connor, Walter Kolch
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177058 (2017)
Molecularly targeted therapeutics hold promise of revolutionizing treatments of advanced malignancies. However, a large number of patients do not respond to these treatments. Here, we take a systems biology approach to understand the molecular mechan
Externí odkaz:
https://doaj.org/article/e1dff045538248eb9ca20ebb0272e39e
Publikováno v:
Stem Cell Research, Vol 13, Iss 2, Pp 284-299 (2014)
Currently there is intense interest in using mesenchymal stem cells (MSC) for therapeutic interventions in many diseases and conditions. To accelerate the therapeutic use of stem cells we must understand how they sense their environment. Primary cili
Externí odkaz:
https://doaj.org/article/ea5e9721e5fd4b1caf7716ea95669dc2
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 2, p e1003385 (2014)
The ever-increasing capacity of biological molecular data acquisition outpaces our ability to understand the meaningful relationships between molecules in a cell. Multiple databases were developed to store and organize these molecular data. However,
Externí odkaz:
https://doaj.org/article/d006400b1196443dad7b0bd192e0d3ed
Autor:
Boris N. Kholodenko, Oleksii S. Rukhlenko, Vadim Zhernovkov, Vladimir Lobaskin, Hilary Cassidy, Walter Kolch, David Matallanas, Aleksandar Krstic, Tapesh Santra
Publikováno v:
Toxicological Sciences
A rapid increase of new nanomaterial products poses new challenges for their risk assessment. Current traditional methods for estimating potential adverse health effect of nanomaterials (NMs) are complex, time consuming and expensive. In order to dev
Autor:
Nicole Radde, Dirk Fey, Caterina Thomaseth, Boris N. Kholodenko, Tapesh Santra, Oleksii S. Rukhlenko
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
Scientific Reports
Modular Response Analysis (MRA) is a method to reconstruct signalling networks from steady-state perturbation data which has frequently been used in different settings. Since these data are usually noisy due to multi-step measurement procedures and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e388c1ed70f446ae66b2f938d65875
Autor:
Aleksandar Krstic, Vadim Zhernovkov, Tapesh Santra, Vladimir Lobaskin, Boris N. Kholodenko, Oleksii S. Rukhlenko, Walter Kolch, David Matallanas, Hilary Cassidy
BackgroundCarbon nanotubes (CNTs) usage has rapidly increased in the last few decades due to their unique properties, exploited in various industrial and commercial products. Certain types of CNTs cause adverse health effects, including chronic infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292ff7a7625d3b96367615a664a11a45
Publikováno v:
Current Opinion in Systems Biology
In this review we discuss the origination and evolution of Modular Response Analysis (MRA), which is a physics-based method for reconstructing quantitative topological models of biochemical pathways. We first focus on the core theory of MRA, demonstr
Autor:
Tapesh Santra
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
A common experimental approach for studying signal transduction networks (STNs) is to measure the steady state concentrations of their components following perturbations to individual components. Such data is frequently used to reconstruct topologica