Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Tapas K. Kundu"'
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e38193- (2024)
Breast cancer is a highly complex disease with multiple subtypes. While many of the breast cancer cases are sporadic some can be familial or hereditary. Genomic integrity is closely monitored by several mechanisms, such as DNA damage machinery and mi
Externí odkaz:
https://doaj.org/article/d8fc13f62c4647c5a7f1c361649cda48
Autor:
Isabel Paiva, Jonathan Seguin, Iris Grgurina, Akash Kumar Singh, Brigitte Cosquer, Damien Plassard, Laura Tzeplaeff, Stephanie Le Gras, Ludovica Cotellessa, Charles Decraene, Johanne Gambi, Rafael Alcala-Vida, Muthusamy Eswaramoorthy, Luc Buée, Jean-Christophe Cassel, Paolo Giacobini, David Blum, Karine Merienne, Tapas K. Kundu, Anne-Laurence Boutillier
Publikováno v:
Neurobiology of Disease, Vol 198, Iss , Pp 106538- (2024)
Aging is the main risk factor of cognitive neurodegenerative diseases such as Alzheimer's disease, with epigenome alterations as a contributing factor. Here, we compared transcriptomic/epigenomic changes in the hippocampus, modified by aging and by t
Externí odkaz:
https://doaj.org/article/f5714d9bc754442fab0e4c7aa97ead64
Autor:
Takahiro Nakayama, Akash K. Singh, Toshiyuki Fukutomi, Noriyuki Uchida, Yasuo Terao, Hiroki Hamada, Takahiro Muraoka, Eswaramoorthy Muthusamy, Tapas K. Kundu, Kimio Akagawa
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114101- (2024)
Summary: Syntaxin-1A (stx1a) repression causes a neurodevelopmental disorder phenotype, low latent inhibition (LI) behavior, by disrupting 5-hydroxytryptaminergic (5-HTergic) systems. Herein, we discovered that lysine acetyltransferase (KAT) 3B incre
Externí odkaz:
https://doaj.org/article/7082df1e29b6458ba0cf338791935a20
Autor:
Smita Pal, Poonam Mehta, Ankita Pandey, Anam Ara, Ujjala Ghoshal, Uday C. Ghoshal, Rajesh Pandey, Raj Kamal Tripathi, Prem N. Yadav, Ramachandran Ravishankar, Tapas K. Kundu, Singh Rajender
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The emergence and rapid evolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) caused a global crisis that required a detailed characterization of the dynamics of mutational pattern of the viral genome for comprehending its epidemi
Externí odkaz:
https://doaj.org/article/7da72e959f0d4f85b14420778724f17f
Autor:
Franziska Müller, Francesco De Virgiliis, Guiping Kong, Luming Zhou, Elisabeth Serger, Jessica Chadwick, Alexandros Sanchez-Vassopoulos, Akash Kumar Singh, Muthusamy Eswaramoorthy, Tapas K. Kundu, Simone Di Giovanni
Publikováno v:
PLoS Biology, Vol 20, Iss 9 (2022)
The interruption of spinal circuitry following spinal cord injury (SCI) disrupts neural activity and is followed by a failure to mount an effective regenerative response resulting in permanent neurological disability. Functional recovery requires the
Externí odkaz:
https://doaj.org/article/e0a0bb5bf34049b1a2d42e9cc9d97d80
Autor:
Stephanie Kaypee, Smitha Asoka Sahadevan, Shilpa Patil, Piya Ghosh, Neeladri Sekhar Roy, Siddhartha Roy, Tapas K. Kundu
Publikováno v:
iScience, Vol 4, Iss , Pp 260-272 (2018)
Summary: The transcriptional co-activator p300 is essential for p53 transactivation, although its precise role remains unclear. We report that p53 activates the acetyltransferase activity of p300 through the enhancement of p300 autoacetylation. Autoa
Externí odkaz:
https://doaj.org/article/d54a94cecbb74900ad00fcd991d011c1
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Externí odkaz:
https://doaj.org/article/ee5ce3d1991c4890be6154066cbdf8ab
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Luteolin, a polyphenolic plant flavonoid, has been attributed with numerous beneficial properties like anti-cancer, antioxidant, and anti-inflammatory action. Luteolin has been reported earlier to be neuroprotective in models of spinal cord injury an
Externí odkaz:
https://doaj.org/article/2331e970d54f4e218b1088b600c3e042
Publikováno v:
Journal of Evidence-Based Complementary & Alternative Medicine, Vol 22 (2017)
Background. Status of autonomic homoeostasis in hemostasic disturbances due to hemophilia needs to be studied. Objectives. To compare autonomic nervous system markers measured by heart rate variability (HRV) and blood flow variability (BFV) in hemoph
Externí odkaz:
https://doaj.org/article/33abfc407fdf4a0c802f9bd6edb8e039
Autor:
Swati Srivastava, Sanjay Kumar, Rohini Bhatt, Ravishankar Ramachandran, Arun K Trivedi, Tapas K Kundu
Publikováno v:
The Journal of Biochemistry. 173:417-433
Acetylation is one of the key post-translational protein modifications catalysed by the protein lysine acetyltransferases (KATs). KATs catalyse the transfer of acetyl groups to the epsilon-amino groups of lysine residues in histones and non-histone p