Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Tapani Ronni"'
Autor:
Nabanita Biswas, Shufeng Liu, Tapani Ronni, Steven E Aussenberg, Weiqun Liu, Takashi Fujita, Tianyi Wang
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21153 (2011)
The innate immune responses to virus infection are initiated by either Toll-like receptors (TLR3/7/8/9) or cytoplasmic double-stranded RNA (dsRNA)-recognizing RNA helicases RIG-I and MDA5. To avoid causing injury to the host, these signaling pathways
Externí odkaz:
https://doaj.org/article/21dc93d9a6704c9ab988e50ae4334a03
Autor:
Sinisa Dovat, Christoph W. Turk, Kimberly J. Payne, Zafer Gurel, Tapani Ronni, Sam Ho, Jason A. Kuchar
Publikováno v:
Journal of Biological Chemistry. 283:8291-8300
Ikaros encodes a zinc finger protein that is involved in heritable gene silencing. In hematopoietic cells, Ikaros localizes to pericentromeric heterochromatin (PC-HC) where it recruits its target genes, resulting in their activation or repression via
Autor:
Tapani Ronni, M E Haberland, Genhong Cheng, Michael Haykinson, Stephen T. Smale, Vishal Agarwal
Publikováno v:
Molecular and Cellular Biology. 23:2543-2555
Toll-like receptor 4 (TLR4) mediates the host response to lipopolysaccharide (LPS) by promoting the activation of pro- and anti-inflammatory cytokine genes. To activate each gene, numerous signal transduction pathways are required. The adaptor protei
Autor:
Krister Melén, Ilkka Julkunen, Jaana Pirhonen, Tapani Ronni, Sampsa Matikainen, Timo Sareneva
Publikováno v:
Cytokine & Growth Factor Reviews. 12:171-180
Despite vaccines and antiviral substances influenza still causes significant morbidity and mortality world wide. Better understanding of the molecular mechanisms of influenza virus replication, pathogenesis and host immune responses is required for t
Autor:
Timo Sareneva, Ilkka Julkunen, Päivi J. Koskinen, Tapani Ronni, Sampsa Matikainen, Anne Lehtonen
Publikováno v:
Blood. 93:1980-1991
Interferon-alpha (IFN-alpha) is a pleiotropic cytokine that has antiviral, antiproliferative, and immunoregulatory functions. There is increasing evidence that IFN-alpha has an important role in T-cell biology. We have analyzed the expression of IL-2
Autor:
TAPANI RONNI, SAMPSA MATIKAINEN, ANNE LEHTONEN, JORMA PALVIMO, JOELLE DELLIS, FRANÇOISE VAN EYLEN, JEAN-FRANCOIS GOETSCHY, MICHEL HORISBERGER, JEAN CONTENT, ILKKA JULKUNEN
Publikováno v:
Journal of Interferon & Cytokine Research. 18:773-781
Interferon (IFN)-inducible human MxA protein mediates resistance against influenza and several other RNA viruses. The MxA gene is under the control of type I IFN and, in certain cell types, is also directly activated by viruses. Here we show that in
Publikováno v:
Journal of Biological Chemistry. 271:23478-23486
Interferon-inducible Mx proteins belong to the family of large GTPases and are highly homologous with dynamins within their GTP-binding domain. Cytoplasmically localized human MxA protein mediates resistance to influenza and several other viruses, wh
Enzymatic characterization of interferon-induced antiviral GTPases murine Mx1 and human MxA proteins
Publikováno v:
Journal of Biological Chemistry. 269:2009-2015
Interferons induce a number of different proteins which mediate the antiproliferative, antiviral, and immunomodulatory functions of interferons. Interferon-induced Mx proteins, which confer resistance to influenza, vesicular stomatitis, and measles v
Autor:
Tianyi Wang, Weiqun Liu, Tapani Ronni, Shufeng Liu, Nabanita Biswas, Steven E. Aussenberg, Takashi Fujita
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 6, p e21153 (2011)
PLoS ONE, Vol 6, Iss 6, p e21153 (2011)
Background: The innate immune responses to virus infection are initiated by either Toll-like receptors (TLR3/7/8/9) or cytoplasmic double-stranded RNA (dsRNA)-recognizing RNA helicases RIG-I and MDA5. To avoid causing injury to the host, these signal
Publikováno v:
Journal of Biological Chemistry. 267:25898-25907
Interferons induce a number of different proteins that mediate the antiproliferative, antiviral, and immunomodulatory functions of interferons. At least three different proteins mediate the antiviral response, and one of them, Mx protein, specificall