Allosteric control of Ubp6 and the proteasome via a bidirectional switch

Autor: Ka Ying Sharon Hung, Sven Klumpe, Markus R. Eisele, Suzanne Elsasser, Geng Tian, Shuangwu Sun, Jamie A. Moroco, Tat Cheung Cheng, Tapan Joshi, Timo Seibel, Duco Van Dalen, Xin-Hua Feng, Ying Lu, Huib Ovaa, John R. Engen, Byung-Hoon Lee, Till Rudack, Eri Sakata, Daniel Finley

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

The interplay of the proteasome and deubiquitinase Ubp6 is crucial for the degradation of ubiquitylated substrates. Here, the authors provide structural insights into the allosteric mechanism by which the activities of both Ubp6 and the proteasome ar

Externí odkaz: https://doaj.org/article/0db17aeb4b8c4a309992d0d564111f7b

Atomic structures of an entire contractile injection system in both the extended and contracted states

Autor: Hyengseop Jeong, Alok K. Mitra, Ambroise Desfosses, Jaekyung Hyun, Mark R. H. Hurst, Matthew Jessop, J. Bernard Heymann, Jan Felix, Irina Gutsche, Tapan Joshi, Hariprasad Venugopal

Publikováno v: Nature Microbiology
Nature Microbiology, 2019, 4 (11), pp.1885-1894. ⟨10.1038/s41564-019-0530-6⟩
Nature Microbiology, Nature Publishing Group, 2019, 4 (11), pp.1885-1894. ⟨10.1038/s41564-019-0530-6⟩
Nature microbiology

Contractile injection systems are sophisticated multiprotein nanomachines that puncture target cell membranes. Although the number of atomic-resolution insights into contractile bacteriophage tails, bacterial type six secretion systems and R-pyocins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59e0e4bb2cb314089090a896cb950b7
https://hal.univ-grenoble-alpes.fr/hal-02417597

Revealing the atomic-level organization of a bacterial microinjection nanodevice

Autor: Hariprasad Venugopal, Ambroise Desfosses, Alok K. Mitra, Mark R. H. Hurst, Jae Hyun, Pushpanjali Bhardwaj, Tapan Joshi

Publikováno v: Acta Crystallographica Section A Foundations and Advances. 73:C1325-C1325

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5bf4e99a78d0666dbf78646d5f47524
https://doi.org/10.1107/s205327331708250x

Adverse effects of botulinum neurotoxin A in spasticity management

Autor: Sonal Joshi, Tapan Joshi

Publikováno v: International journal of Nutrition, Pharmacology, Neurological Diseases. 1:126

Over the last few decades, Botulinum neurotoxin has evolved from a well-publicized public health threat of food-borne illness, due to contaminated foods, to a widely used therapeutic measure. Botulinum neurotoxin A is one of the seven distinct neurot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71467a785552562d2ffbe3669e920345
https://doi.org/10.4103/2231-0738.84202

Poster 328: AIDS Associated Vacuolar Myelopathy - A Rehabilitation Challenge: A Case Report

Autor: Tapan Joshi, Sandeep Singh, Katherine D. Travnicek

Publikováno v: PM&R. 1:S247-S247

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18204402ae6b2425cab88e4f767a955c
https://doi.org/10.1016/j.pmrj.2009.08.355