A multimodal neural network with gradient blending improves predictions of survival and metastasis in sarcoma

Autor: Anthony Bozzo, Alex Hollingsworth, Subrata Chatterjee, Aditya Apte, Jiawen Deng, Simon Sun, William Tap, Ahmed Aoude, Sahir Bhatnagar, John H. Healey

Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-10 (2024)

Abstract The objective of this study is to develop a multimodal neural network (MMNN) model that analyzes clinical variables and MRI images of a soft tissue sarcoma (STS) patient, to predict overall survival and risk of distant metastases. We compare

Externí odkaz: https://doaj.org/article/c1fa4e3de9344b74a0f36e286225df9a

Healthcare Providers’ Knowledge, Attitude, and Practices Regarding Prevention of Mpox in Vietnam

Autor: Han Thi Ngoc Nguyen, Tap Van Nguyen, Khanh Van Tran, Hau Viet Nguyen, Lan Y Vo, Pham Le An, Tuan Diep Tran, Giao Huynh

Publikováno v: SAGE Open, Vol 14 (2024)

The re-emergence of the mpox virus in the context of the COVID-19 pandemic is affecting people worldwide. This study aimed to investigate knowledge, attitude, and practice (KAP) toward mpox among healthcare providers in Vietnam. A cross-sectional stu

Externí odkaz: https://doaj.org/article/7dd42a8183fd43eebe25bf5714879fda

Association between Clinical Frailty Scale and mortality 24 months after hospitalisation in adult patients with COVID-19

Autor: Julia Minnema, Melvin Lafeber, Roos S.G. Sablerolles, Janneke A.L. van Kempen, Lisanne Tap, Harmke A. Polinder-Bos, Bob P.A. van de Loo, Hugo van der Kuy, Miriam C. Faes, Jacomien Aleman, Jos Tournoy, Lorenz Van der Linden, Marco Gambera, Isabella Martignoni, Ronald Van Etten, Hein van Onzenoort, Mariette Kappers, Peter van Wijngaarden, Jose Verstijnen, Vera Theeuwes, Marleen Kemper, Elise Slob, Ferdi Sombogaard, Heshu Abdullah-Koolmees, Roland van den Berg, Hugo de Wit, Betul Dilek, Freija Hogenhuis, Vahid Buyukayten, Britt te Brake, Margriet Nieuwenhuijzen, Maria Scheeren, Madelief de Wit, Arjan Bulsink, Ingrid van Haelst, Peter ter Horst, Rosalie Moorlag, Anja Vos, Annemiek Otten-Helmers, Erik van Kan, Marije Voskamp, Marieke Ebbens, Marieke Ezinga, Cees van Nieuwkoop, Loes Visser, Caroline Ghazarian, Doranne Hilarius, Gonneke Hermanides, Carlinda Bresser, Judith Derijks-Engwegen, Ebbie Boemaars, Zahira Getrouw, Barbara Maat, Peter Wierenga, Tessa Bosch, Lisanne Krens, Kajie Liang, Langeza Saleh, Milou van Heuckelum, Linda Hendriksen, Paul van der Linden, Kaylen Guda, Kristel Crommentuijn, Ilse Cornelissen-Wesseling, Jeroen Diepstraten, Jacobien Ellerbroek, Saskia Coenradie, Debbie Deben, Kim Hurkens, Dennis Wong, Marion Vromen, Marjolein de Bock, Suzan Savelkoul, Saskia Wolters, Louise Andrews, Eefje Jong, Rosanne Kranenburg, Joana Soares, Fatima Falcao, Mariana Solano, Erica Viegas, Margarida Falcao, Helena Farinha, Dina Mendes, Joao Rijo, Marta Miarons, Maria Queralt Gorgas, Cristina García Yubero, Laura Portillo Horcajada, Kim Keijzers, Silke Lim, Linden Ashfield, Helen Bell, Naomi Fitzhugh, Glenda Fleming, Nicola Goodfellow, Joanne Hanley, Michael Scott, Simon P. Mooijaart, Jacobijn Gussekloo, Petra Elders, Geeske Peeters

Publikováno v: Heliyon, Vol 10, Iss 23, Pp e40456- (2024)

Background: The clinical frailty scale (CFS) was used as a triage tool for medical decision making during the COVID-19 pandemic. The CFS has been posed as a suitable risk marker for in-hospital mortality in COVID-19 patients. We evaluated whether the

Externí odkaz: https://doaj.org/article/c6e84359db6c419a80d153ef70cdacce

Cancer-associated Histone H3 N-terminal arginine mutations disrupt PRC2 activity and impair differentiation

Autor: Benjamin A. Nacev, Yakshi Dabas, Matthew R. Paul, Christian Pacheco, Michelle Mitchener, Yekaterina Perez, Yan Fang, Alexey A. Soshnev, Douglas Barrows, Thomas Carroll, Nicholas D. Socci, Samantha C. St. Jean, Sagarika Tiwari, Michael J. Gruss, Sebastien Monette, William D. Tap, Benjamin A. Garcia, Tom Muir, C. David Allis

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Dysregulated epigenetic states are a hallmark of cancer and often arise from genetic alterations in epigenetic regulators. This includes missense mutations in histones, which, together with associated DNA, form nucleosome core particles. How

Externí odkaz: https://doaj.org/article/a8ab4f3e792a49f58af3860467b6cc16

Effects of Zn pollution on soil: Pollution sources, impacts and solutions

Autor: Huu-Tap Van, Van Hung Hoang, Luong Thi Quynh Nga, Van Quang Nguyen

Publikováno v: Results in Surfaces and Interfaces, Vol 17, Iss , Pp 100360- (2024)

The management of zinc (Zn) pollution in soil and its environmental impact is a critical concern that requires a comprehensive approach. This article presents a synthesis of research on assessing and managing Zn pollution, encompassing environmental

Externí odkaz: https://doaj.org/article/5f827b40af294f73aaa1f0c6f79c7357