In vitro and in vivo safety studies indicate that R15, a synthetic polyarginine peptide, could safely reverse the effects of unfractionated heparin

Autor: Tong Li, Zhiyun Meng, Xiaoxia Zhu, Hui Gan, Ruolan Gu, Zhuona Wu, Taoyun Liu, Peng Han, Jiarui Gao, Su Han, Guifang Dou

Publikováno v: FEBS Open Bio, Vol 11, Iss 9, Pp 2468-2489 (2021)

Unfractionated heparin (UFH) is an anionic glycosaminoglycan that is widely used to prevent blood clotting. However, in certain cases, unwanted side effects can require it to be neutralized. Protamine sulfate (PS), a basic peptide rich in arginine, i

Externí odkaz: https://doaj.org/article/f971f15e96b14a71873d58604b5a3f66

Cepharanthine Ameliorates Pulmonary Fibrosis by Inhibiting the NF-κB/NLRP3 Pathway, Fibroblast-to-Myofibroblast Transition and Inflammation

Autor: Guangrui Chen, Jian Li, Huimeng Liu, Huiyu Zhou, Mingqiu Liu, Di Liang, Zhiyun Meng, Hui Gan, Zhuona Wu, Xiaoxia Zhu, Peng Han, Taoyun Liu, Ruolan Gu, Shuchen Liu, Guifang Dou

Publikováno v: Molecules, Vol 28, Iss 2, p 753 (2023)

Pulmonary fibrosis (PF) is one of the sequelae of Corona Virus Disease 2019 (COVID-19), and currently, lung transplantation is the only viable treatment option. Hence, other effective treatments are urgently required. We investigated the therapeutic

Externí odkaz: https://doaj.org/article/edcd1a39baec469a804b80b92ec340bf

A rapid quantitative method by liquid chromatography–tandem mass spectrometry for the measurement of anthocyanins and their metabolic characteristics in Sprague–Dawley rats

Autor: Yueru Lian, Liyun Niu, Zhiyun Meng, Xiaoxia Zhu, Ruolan Gu, Zhuona Wu, Jian Li, Peng Han, Taoyun Liu, Hui Gan, Guifang Dou

Publikováno v: European Food Research and Technology. 248:2109-2124

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8087009909463eb41a9853e0650a483d
https://doi.org/10.1007/s00217-022-04034-7

Recombinant Human HPS Protects Mice and Nonhuman Primates from Acute Liver Injury

Autor: Chutse Wu, Gui-Fang Dou, Xiaofang Wang, Yang Yang, Hui Chen, Lihou Dong, Miao Yu, Taoyun Liu, Yue Wan, Zhai Huali

Publikováno v: International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12886
International Journal of Molecular Sciences, Vol 22, Iss 12886, p 12886 (2021)
International Journal of Molecular Sciences

Acute liver injury shares a common feature of hepatocytes death, immune system disorders, and cellular stress. Hepassocin (HPS) is a hepatokine that has ability to promote hepatocytes proliferation and to protect rats from D-galactose (D-Gal)- or car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324a961c3099f504f530fa690689fa03
https://doi.org/10.3390/ijms222312886

Application of ultra high-performance liquid chromatography tandem mass spectrometry to investigate the regioselective glucuronidation of icaritin in vitro

Autor: Sun Wenzhong, Hui Gan, Jian Peng, Guifang Dou, Ruolan Gu, Xinyu Wang, Ying Zheng, Mingji Jin, Yi Rong, Taoyun Liu, Zhuona Wu, Zhiyun Meng, Xiaoxia Zhu, Jian Li

Publikováno v: Journal of pharmaceutical and biomedical analysis. 154

Icaritin is one of the Epimedium products with various biological activities. In the present study, we developed a rapid, reliable and robust UHPLC–MS/MS method to simultaneously determine unconjugated icaritin and its multiple glucuronides (icarit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02fc2d88ba16937dcba71f44ebe92e3
https://pubmed.ncbi.nlm.nih.gov/29587224