Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tanzilya, Khayrullina"'
Autor:
Roland Staal, Tanzilya Khayrullina, Rie Christensen, Sara Hestehave, Hua Zhou, Manuel Cajina, Megan E. Nattini, Adarsh Gandhi, Shaun M. Fallon, Megan Schmidt, Stevin H. Zorn, Robbin M. Brodbeck, Gamini Chandrasena, Märta Segerdahl, Nathalie Breysse, Allen T. Hopper, Thomas Möller, Gordon Munro
Publikováno v:
European Journal of Pain. 26:1304-1321
P2X7 receptor antagonists have potential for treating various central nervous system (CNS) diseases, including neuropathic pain, although none have been approved for clinical use. Reasons may include insufficient understanding of P2X7 receptor signal
Autor:
Suresh Poda, Robb Brodbeck, Veena Menon, Manuel Cajina, Elena Dale, Annemette V. Thougaard, Martin Juhl, Londye Calice, Hopper Allen T, Thomas Möller, Roland G. W. Staal, Michel Grenon, Stevin H. Zorn, Kenneth A. Jones, Gamini Chandrasena, Tanzilya Khayrullina, Jorrit J. Hornberg, Lassina Badolo, John Paul Kilburn, Dekun Song, Adarsh Gandhi, Megan Nattini, Hong Zhang, Christian Thomsen, Gennady N. Smagin
Publikováno v:
Journal of Medicinal Chemistry. 64:4891-4902
There remains an insufficient number of P2X7 receptor antagonists with adequate rodent potency, CNS permeability, and pharmacokinetic properties from which to evaluate CNS disease hypotheses preclinically. Herein, we describe the molecular pharmacolo
Autor:
Stevin H. Zorn, Thomas Mӧller, S. Fallon, Roland G. W. Staal, Gordon Munro, Brian Cambpell, Gamini Chandrasena, Hua Zhou, Lars Christian Biilmann Rønn, Manuel Cajina, Megan Nattini, Andrew Hu, Scott Davis, Hong Zhang, Suresh Poda, Elena Dale, Tanzilya Khayrullina
Publikováno v:
European Journal of Pharmacology. 795:1-7
Neuropathic pain is a debilitating, chronic condition with a significant unmet need for effective treatment options. Recent studies have demonstrated that in addition to neurons, non-neuronal cells such as microglia contribute to the initiation and m
Autor:
Roland G W, Staal, Tanzilya, Khayrullina, Hong, Zhang, Scott, Davis, Shaun M, Fallon, Manuel, Cajina, Megan E, Nattini, Andrew, Hu, Hua, Zhou, Suresh Babu, Poda, Stevin, Zorn, Gamini, Chandrasena, Elena, Dale, Brian, Cambpell, Lars Christian, Biilmann Rønn, Gordon, Munro, Thomas, Mӧller
Publikováno v:
European journal of pharmacology. 795
Neuropathic pain is a debilitating, chronic condition with a significant unmet need for effective treatment options. Recent studies have demonstrated that in addition to neurons, non-neuronal cells such as microglia contribute to the initiation and m
Publikováno v:
The Journal of Immunology. 181:721-735
PGE2, an endogenous lipid mediator released in inflammatory conditions, affects both dendritic cell (DC) differentiation and maturation. Whereas the effect of PGE2 on fully differentiated DC was studied extensively, little is known about its effects
Publikováno v:
Arthritis & Rheumatism. 56:2608-2619
Objective Recently, Th17 cells, a new subset of CD4+ T cells, emerged as major players in inflammation/autoimmunity. Maintenance of the Th17 phenotype requires interleukin-23 (IL-23), whereas the Th1-promoting cytokine IL-12p70 exerts a negative effe
Publikováno v:
Future Science OA
Aim: Lipids such as prostaglandins, leukotrienes and thromboxanes are released as a result of an inflammatory episode in pain (central and peripheral). Methodology & results: To measure these lipids as potential mechanistic biomarkers in neuropathic
Publikováno v:
The FASEB Journal. 22
Publikováno v:
Blood. 111(1)
Following antigen acquisition and maturation, dendritic cells (DCs) disengage from the extracellular matrix, cross basement membranes, and travel to draining lymph nodes to activate T cells. CCR7 expression is necessary but not sufficient for the dir
Autor:
Tanzilya Khayrullina, Doina Ganea, Ming Zhang, Ronald F. Tuma, Frances A. Emig, Amir F. Sheibanie, Jui-Hung Yen
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 178(12)
Although Crohn’s disease has been traditionally considered to be Th1-mediated, the newly identified Th17 cells emerged recently as crucial participants. Th1/Th17 differentiation is controlled primarily by the IL-12 family of cytokines secreted by a