Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Tanya T Paull"'
Autor:
Seung W Ryu, Rose Stewart, D Chase Pectol, Nicolette A Ender, Oshadi Wimalarathne, Ji-Hoon Lee, Carlos P Zanini, Antony Harvey, Jon M Huibregtse, Peter Mueller, Tanya T Paull
Publikováno v:
PLoS Biology, Vol 18, Iss 7, p e3000606 (2020)
The 70 kDa heat shock protein (HSP70) family of chaperones are the front line of protection from stress-induced misfolding and aggregation of polypeptides in most organisms and are responsible for promoting the stability, folding, and degradation of
Externí odkaz:
https://doaj.org/article/316dda2e58104b5c83edc6755636be78
Autor:
Nodar Makharashvili, Sucheta Arora, Yizhi Yin, Qiong Fu, Xuemei Wen, Ji-Hoon Lee, Chung-Hsuan Kao, Justin WC Leung, Kyle M Miller, Tanya T Paull
Publikováno v:
eLife, Vol 7 (2018)
The Sae2/CtIP protein is required for efficient processing of DNA double-strand breaks that initiate homologous recombination in eukaryotic cells. Sae2/CtIP is also important for survival of single-stranded Top1-induced lesions and CtIP is known to a
Externí odkaz:
https://doaj.org/article/6e843027c69743fa94b5749f44677786
Autor:
Nguyen Ngoc Hoa, Junya Kobayashi, Masato Omura, Mayumi Hirakawa, Soo-Hyun Yang, Kenshi Komatsu, Tanya T Paull, Shunichi Takeda, Hiroyuki Sasanuma
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124495 (2015)
Homologous recombination plays a key role in the repair of double-strand breaks (DSBs), and thereby significantly contributes to cellular tolerance to radiotherapy and some chemotherapy. DSB repair by homologous recombination is initiated by 5' to 3'
Externí odkaz:
https://doaj.org/article/cb51bc7b7c18474395d9552d7536275e
Autor:
Prabha Sarangi, Roland Steinacher, Veronika Altmannova, Qiong Fu, Tanya T Paull, Lumir Krejci, Matthew C Whitby, Xiaolan Zhao
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004899 (2015)
Protein modifications regulate both DNA repair levels and pathway choice. How each modification achieves regulatory effects and how different modifications collaborate with each other are important questions to be answered. Here, we show that sumoyla
Externí odkaz:
https://doaj.org/article/2a0d4b114b714d5795ce8234dcb3dc53
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e97969 (2014)
Resveratrol has been widely reported to reduce cancer progression in model systems and to selectively induce cell death in transformed cell lines. Many enzymes have been reported to respond to resveratrol in mammalian cells, including the Ataxia-Tela
Externí odkaz:
https://doaj.org/article/53f15ba66b394658ab10d4aea78e7784
Autor:
Ann Demogines, Alysia M East, Ji-Hoon Lee, Sharon R Grossman, Pardis C Sabeti, Tanya T Paull, Sara L Sawyer
Publikováno v:
PLoS Genetics, Vol 6, Iss 10, p e1001169 (2010)
In human cells, DNA double-strand breaks are repaired primarily by the non-homologous end joining (NHEJ) pathway. Given their critical nature, we expected NHEJ proteins to be evolutionarily conserved, with relatively little sequence change over time.
Externí odkaz:
https://doaj.org/article/8f7c3f34c7be4c1a8a2d235dc7ea4ebf
Autor:
Phillip R. Woolley, Xuemei Wen, Olivia M. Conway, Nicolette A. Ender, Ji-Hoon Lee, Tanya T. Paull
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113896- (2024)
Summary: The ataxia telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA damage response and also an important sensor of oxidative stress. Analysis of gene expression in ataxia-telangiectasia (A-T) patient brain tissue shows t
Externí odkaz:
https://doaj.org/article/6b926ebf0e18404b93723ed8d502abf8
Autor:
Rajashree A. Deshpande, Alberto Marin-Gonzalez, Hannah K. Barnes, Phillip R. Woolley, Taekjip Ha, Tanya T. Paull
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The Mre11-Rad50-Nbs1 (MRN) complex recognizes and processes DNA double-strand breaks for homologous recombination by performing short-range removal of 5ʹ strands. Endonucleolytic processing by MRN requires a stably bound protein at the brea
Externí odkaz:
https://doaj.org/article/dd444a1edaae40df907eb9173c278862
Autor:
Hyeongsun Jeong, Minwoo Wie, In-Joon Baek, Gyuwon Sohn, Si-Hyeon Um, Seon-Gyeong Lee, Yuri Seo, Jaesun Ra, Eun A Lee, Shinseog Kim, Byung Gyu Kim, Rajashree A. Deshpande, Tanya T. Paull, Joo Seok Han, Taejoon Kwon, Kyungjae Myung
Publikováno v:
Cells, Vol 11, Iss 24, p 4095 (2022)
Thyroid hormone receptor-interacting protein 13 (TRIP13) participates in various regulatory steps related to the cell cycle, such as the mitotic spindle assembly checkpoint and meiotic recombination, possibly by interacting with members of the HORMA
Externí odkaz:
https://doaj.org/article/4b2e977fd15442d1926016ad0d2944a2
Autor:
Shan Zha, Tanya T. Paull, Peter J. Mckinnon, Dong Wang, Verna M. Estes, Jun Xu, Brian J. Lee, Yang Li, Kenta Yamamoto, Ji-Hoon Lee, Demis Menolfi, Lisa M. Houghton, Maja Milanovic
Sup. Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875f69e98a19476123d2a783f0cf7c90
https://doi.org/10.1158/0008-5472.22427259.v1
https://doi.org/10.1158/0008-5472.22427259.v1
