Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Tanya T Paull"'
Autor:
Rajashree A. Deshpande, Alberto Marin-Gonzalez, Hannah K. Barnes, Phillip R. Woolley, Taekjip Ha, Tanya T. Paull
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The Mre11-Rad50-Nbs1 (MRN) complex recognizes and processes DNA double-strand breaks for homologous recombination by performing short-range removal of 5ʹ strands. Endonucleolytic processing by MRN requires a stably bound protein at the brea
Externí odkaz:
https://doaj.org/article/dd444a1edaae40df907eb9173c278862
Autor:
Phillip R. Woolley, Xuemei Wen, Olivia M. Conway, Nicolette A. Ender, Ji-Hoon Lee, Tanya T. Paull
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113896- (2024)
Summary: The ataxia telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA damage response and also an important sensor of oxidative stress. Analysis of gene expression in ataxia-telangiectasia (A-T) patient brain tissue shows t
Externí odkaz:
https://doaj.org/article/6b926ebf0e18404b93723ed8d502abf8
Autor:
Jacob Paiano, Wei Wu, Shintaro Yamada, Nicholas Sciascia, Elsa Callen, Ana Paola Cotrim, Rajashree A. Deshpande, Yaakov Maman, Amanda Day, Tanya T. Paull, André Nussenzweig
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Recombination requires DNA break formation by SPO11, following which SPO11 is thought to be released. Here, the authors show that meiotic hotspots retain SPO11 through a recombination intermediate dependent on the methyltransferase PRDM9, and that th
Externí odkaz:
https://doaj.org/article/fe2f3dab8f70455daf145802e93451d5
Autor:
Hyeongsun Jeong, Minwoo Wie, In-Joon Baek, Gyuwon Sohn, Si-Hyeon Um, Seon-Gyeong Lee, Yuri Seo, Jaesun Ra, Eun A Lee, Shinseog Kim, Byung Gyu Kim, Rajashree A. Deshpande, Tanya T. Paull, Joo Seok Han, Taejoon Kwon, Kyungjae Myung
Publikováno v:
Cells, Vol 11, Iss 24, p 4095 (2022)
Thyroid hormone receptor-interacting protein 13 (TRIP13) participates in various regulatory steps related to the cell cycle, such as the mitotic spindle assembly checkpoint and meiotic recombination, possibly by interacting with members of the HORMA
Externí odkaz:
https://doaj.org/article/4b2e977fd15442d1926016ad0d2944a2
Autor:
Seung W Ryu, Rose Stewart, D Chase Pectol, Nicolette A Ender, Oshadi Wimalarathne, Ji-Hoon Lee, Carlos P Zanini, Antony Harvey, Jon M Huibregtse, Peter Mueller, Tanya T Paull
Publikováno v:
PLoS Biology, Vol 18, Iss 7, p e3000606 (2020)
The 70 kDa heat shock protein (HSP70) family of chaperones are the front line of protection from stress-induced misfolding and aggregation of polypeptides in most organisms and are responsible for promoting the stability, folding, and degradation of
Externí odkaz:
https://doaj.org/article/316dda2e58104b5c83edc6755636be78
Autor:
Ji-Hoon Lee, Tanya T. Paull
Publikováno v:
Redox Biology, Vol 32, Iss , Pp - (2020)
The Ataxia-telangiectasia mutated (ATM) kinase responds to DNA double-strand breaks and other forms of cellular stress, including reactive oxygen species (ROS). Recent work in the field has uncovered links between mitochondrial ROS and ATM activation
Externí odkaz:
https://doaj.org/article/3fc466e0dc444ec6897ae4e342e1d9b7
Autor:
Tanya E. Johnson, Ji-Hoon Lee, Logan R. Myler, Yi Zhou, Trenell J. Mosley, Soo-Hyun Yang, Nadima Uprety, Jonghwan Kim, Tanya T. Paull
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1471-1483 (2018)
Summary: Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that coordinates the response to DNA double-strand breaks and oxidative stress. NKX3.1, a prostate-specific transcription factor, was recently shown to directly stimulate ATM k
Externí odkaz:
https://doaj.org/article/6347c534ba7d48b784156262ca1f2b90
Autor:
Susannah L. Hewitt, Jason B. Wong, Ji-Hoon Lee, Mayilaadumveettil Nishana, Hongxi Chen, Marc Coussens, Suzzette M. Arnal, Lili M. Blumenberg, David B. Roth, Tanya T. Paull, Jane A. Skok
Publikováno v:
Cell Reports, Vol 21, Iss 4, Pp 979-993 (2017)
Summary: Many DNA lesions associated with lymphoid malignancies are linked to off-target cleavage by the RAG1/2 recombinase. However, off-target cleavage has mostly been analyzed in the context of DNA repair defects, confounding any mechanistic under
Externí odkaz:
https://doaj.org/article/b10cf388bd314ed79c6fa144a69a4a3c
Autor:
Shan Zha, Tanya T. Paull, Peter J. Mckinnon, Dong Wang, Verna M. Estes, Jun Xu, Brian J. Lee, Yang Li, Kenta Yamamoto, Ji-Hoon Lee, Demis Menolfi, Lisa M. Houghton, Maja Milanovic
ATM kinase is a tumor suppressor and a master regulator of the DNA damage response. Most cancer-associated alterations to ATM are missense mutations at the PI3-kinase regulatory domain (PRD) or the kinase domain. Expression of kinase-dead (KD) ATM pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b98792ddd4a9e236a02544fe4fa800a
https://doi.org/10.1158/0008-5472.c.6512610.v1
https://doi.org/10.1158/0008-5472.c.6512610.v1
Autor:
Shan Zha, Tanya T. Paull, Peter J. Mckinnon, Dong Wang, Verna M. Estes, Jun Xu, Brian J. Lee, Yang Li, Kenta Yamamoto, Ji-Hoon Lee, Demis Menolfi, Lisa M. Houghton, Maja Milanovic
Sup. Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875f69e98a19476123d2a783f0cf7c90
https://doi.org/10.1158/0008-5472.22427259.v1
https://doi.org/10.1158/0008-5472.22427259.v1