Cell Type Diversity Statistic: An Entropy-Based Metric to Compare Overall Cell Type Composition Across Samples

Autor: Tanya T Karagiannis, Stefano Monti, Paola Sebastiani

Publikováno v: Frontiers in Genetics, Vol 13 (2022)

Changes of cell type composition across samples can carry biological significance and provide insight into disease and other conditions. Single cell transcriptomics has made it possible to study cell type composition at a fine resolution. Most single

Externí odkaz: https://doaj.org/article/b5d2e0304ab54cfe9a269487257a0772

Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program

Autor: Tanya T. Karagiannis, John P. Cleary, Busra Gok, Andrew J. Henderson, Nicholas G. Martin, Masanao Yajima, Elliot C. Nelson, Christine S. Cheng

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)

Over 100 million of opioid prescriptions are issued yearly in the USA alone, but the impact of opioid use on the immune system is barely characterized. Here the authors report antiviral immune response is blunted in several types of blood cells from

Externí odkaz: https://doaj.org/article/9e5ff00e7b874089bf331a67319d3183

Bayesian Differential Analysis of Cell Type Proportions

Autor: Tanya T. Karagiannis, Stefano Monti, Paola Sebastiani

SUMMARYThe analysis of cell type proportions in a biological sample should account for the compositional nature of the data but most analyses ignore this characteristic with the risk of producing misleading conclusions. The recent method scCODA appro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d77fa6c24f150b4962a87450e1fed68
https://doi.org/10.1101/2023.01.17.524410

Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity

Autor: Tanya T. Karagiannis, Todd W. Dowrey, Carlos Villacorta-Martin, Monty Montano, Eric Reed, Stacy L. Andersen, Thomas T. Perls, Stefano Monti, George J. Murphy, Paola Sebastiani

Age-related changes in immune cell composition and functionality are associated with multimorbidity and mortality. However, many centenarians delay the onset of aging-related disease suggesting the presence of elite immunity that remains highly funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41a01c0d6e330c327f55973676438d4c
https://doi.org/10.1101/2022.07.06.498968

Metabolite signatures of chronological age, aging, survival, and longevity.

Autor: Sebastiani P; Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA; Department of Medicine, School of Medicine, Tufts University, Boston, MA 02111, USA. Electronic address: psebastiani@tuftsmedicalcenter.org., Monti S; Department of Medicine, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA; Bioinformatics Program, Boston University, Boston, MA 02215, USA., Lustgarten MS; Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA., Song Z; Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA., Ellis D; Institute for Systems Biology, Seattle, WA 98109, USA., Tian Q; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA., Schwaiger-Haber M; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA., Stancliffe E; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA., Leshchyk A; Bioinformatics Program, Boston University, Boston, MA 02215, USA., Short MI; Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA; Department of Medicine, School of Medicine, Tufts University, Boston, MA 02111, USA., Ardisson Korat AV; Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA., Gurinovich A; Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA; Department of Medicine, School of Medicine, Tufts University, Boston, MA 02111, USA., Karagiannis T; Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA; Department of Medicine, School of Medicine, Tufts University, Boston, MA 02111, USA., Li M; Bioinformatics Program, Boston University, Boston, MA 02215, USA., Lords HJ; Bioinformatics Program, Boston University, Boston, MA 02215, USA., Xiang Q; Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA., Marron MM; Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Bae H; Biostatistics Program, College of Health, Oregon State University, Corvallis, OR 97331, USA., Feitosa MF; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130, USA., Wojczynski MK; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63130, USA., O'Connell JR; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Montasser ME; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Schupf N; Department of Epidemiology, Columbia University Medical Center, New York, NY 10032, USA., Arbeev K; Social Science Research Institute, Duke University, Durham, NC 27708, USA., Yashin A; Social Science Research Institute, Duke University, Durham, NC 27708, USA., Schork N; The Translational Genomics Research Institute, Phoenix, AZ 85004, USA., Christensen K; Danish Aging Research Center, University of Southern Denmark, 5000 Odense, Denmark., Andersen SL; Department of Medicine, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA., Ferrucci L; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA., Rappaport N; Institute for Systems Biology, Seattle, WA 98109, USA., Perls TT; Department of Medicine, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA., Patti GJ; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.

Publikováno v: Cell reports [Cell Rep] 2024 Nov 26; Vol. 43 (11), pp. 114913. Date of Electronic Publication: 2024 Nov 05.