Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tanya Smyczek"'
Autor:
Joy Drobnick, Kevin X. Chen, Amy Sambrone, Stephen Schmidt, Lan Wang, Tao Wang, Ping Wu, Jim Nonomiya, Jinhua Chen, Seth F. Harris, Stacey Yeung, Chudi Ndubaku, Zijin Xu, Stephen E. Gould, Huifen Chen, Terry Crawford, Weilan Ye, Tanya Smyczek, Jason Boggs, Rajiv Jesudason, Erin McNamara, Philip Vitorino, Ding Charles Z, Lesley J. Murray
Publikováno v:
ACS Medicinal Chemistry Letters. 6:913-918
Diverse biological roles for mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) have necessitated the identification of potent inhibitors in order to study its function in various disease contexts. In particular, compounds that can be u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4691b6776a7f46441928aa91ff58247f
https://doi.org/10.1021/acsmedchemlett.5b00174
https://doi.org/10.1021/acsmedchemlett.5b00174
Autor:
Stephen E. Gould, Tanya Smyczek, Jesse Bakke, Ailey Crow, Seth F. Harris, Jeffrey Eastham-Anderson, Stacey Yeung, Weilan Ye, Kristina West, Chudi Ndubaku, Philip Vitorino, Erin McNamara
Publikováno v:
Nature. 519:425-430
Cell migration is a stepwise process that coordinates multiple molecular machineries. Using in vitro angiogenesis screens with short interfering RNA and chemical inhibitors, we define here a MAP4K4–moesin–talin–β1-integrin molecular pathway th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09faadef1f0eb20b918c9cd05ce7324
https://doi.org/10.1038/nature14323
https://doi.org/10.1038/nature14323
Autor:
Erin McNamara, Chudi Ndubaku, Ping Wu, Steven Magnuson, Lesley J. Murray, Anthony M. Giannetti, Kristina West, Weilan Ye, Stanley Mark S, Seth F. Harris, Jason Boggs, Brandon J. Bravo, Tanya Smyczek, Jim Nonomiya, Kelly J. Delatorre, Stephen E. Gould, Philip Vitorino, Stephen Schmidt, Huifen Chen, Lan Wang, Terry Crawford, Amy Sambrone
Publikováno v:
Journal of Medicinal Chemistry. 57:3484-3493
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) is a serine/threonine kinase implicated in the regulation of many biological processes. A fragment-based lead discovery approach was used to generate potent and selective MAP4K4 inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e86b1e33d4fd47f98081a9bd8707911
https://doi.org/10.1021/jm500155b
https://doi.org/10.1021/jm500155b
Autor:
Kai H. Barck, Rafael Molina, Olivia Hwang, Ann De Mazière, David Kan, Adrian M. Jubb, Maike Schmidt, Louie Naumovski, Judith Klumperman, Tanya Smyczek, Mallika Singh, Daniel S. Chen, Ian Kasman, Priti S. Hegde, Qinghua Song, Rupal Desai, Jason H. Cheng, Mahrukh Huseni, Weilan Ye, Yin Zhang, Stacey Yeung, Anthony Lima, William F. Forrest, Richard A.D. Carano, Jeffrey Eastham-Anderson, Leisa Johnson, Michelle Nannini, Mark S. Dennis
Publikováno v:
Journal of Clinical Investigation. 123:3997-4009
Many oncology drugs are administered at their maximally tolerated dose without the knowledge of their optimal efficacious dose range. In this study, we describe a multifaceted approach that integrated preclinical and clinical data to identify the opt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f22add24487e0ca9506cd8d2cd90f50
https://doi.org/10.1172/jci67892
https://doi.org/10.1172/jci67892
Autor:
Michael Hörtner, Wiltrud Frisch, Fred Schaper, Peter C. Heinrich, Rudolf Volkmer-Engert, Ulrike Sommer, Tanya Smyczek, Ute Lehmann, Serge Haan
Publikováno v:
Cellular Signalling. 18:40-49
In recent years, the elucidation of the structures of many signalling molecules has allowed new insights into the molecular mechanisms that govern signal transduction events. In the field of cytokine signalling, the solved structures of cytokine/rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac15f50f8bed3417c345b05d6fa1003
https://doi.org/10.1016/j.cellsig.2005.03.019
https://doi.org/10.1016/j.cellsig.2005.03.019
Autor:
Maike, Schmidt, Ann, De Mazière, Tanya, Smyczek, Alane, Gray, Leon, Parker, Ellen, Filvaroff, Dorothy, French, Suzanne, van Dijk, Judith, Klumperman, Weilan, Ye
Publikováno v:
Novartis Foundation symposium. 283
EGFL7 was identified by a number of groups as a putative secreted factor produced by the vascular endothelial cells (ECs). In a recent publication, we showed that EGFL7 regulates midline angioblast migration in zebrafish embryos-a key step in vascula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ab3dd0e4fb4e164e58ebc871d3a0f69
https://pubmed.ncbi.nlm.nih.gov/18300411
https://pubmed.ncbi.nlm.nih.gov/18300411
Autor:
Suzanne van Dijk, Judith Klumperman, Tanya Smyczek, Maike Schmidt, Leon H. Parker, Alane M. Gray, Weilan Ye, Ann De Mazière, Dorothy French, Ellen Filvaroff
Publikováno v:
Vascular Development: Novartis Foundation Symposium 283
EGFL7 was identified by a number of groups as a putative secreted factor produced by the vascular endothelial cells (ECs). In a recent publication, we showed that EGFL7 regulates midline angioblast migration in zebrafish embryos-a key step in vascula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea1c8cfb29e0a1372d8b956db77f218e
https://doi.org/10.1002/9780470319413.ch3
https://doi.org/10.1002/9780470319413.ch3
Autor:
Angela Jörissen, Sandra Diefenbach, Claude Haan, Hildegard Schmitz-VandeLeur, Peter C. Heinrich, Simone Radtke, Serge Haan, Heike M. Hermanns, Iris Behrmann, Tanya Smyczek
Publikováno v:
The Journal of biological chemistry. 280(27)
The presence of a Src homology 2 (SH2) domain sequence similarity in the sequence of Janus kinases (Jaks) has been discussed since the first descriptions of these enzymes. We performed an in depth study to determine the function of the Jak1 SH2 domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3451643be0b79a759136acde922f246f
https://pubmed.ncbi.nlm.nih.gov/15894543
https://pubmed.ncbi.nlm.nih.gov/15894543
Publikováno v:
Vascular Pharmacology. 45:e126-e127
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f7e5757004cb1f2a49d8fed0e92cb67
https://doi.org/10.1016/j.vph.2006.08.336
https://doi.org/10.1016/j.vph.2006.08.336
Autor:
Lee S. Rosen, Priti S. Hegde, Oliva Hwang, Jessica Li, Louie Naumovski, Mahrukh Huseni, Tanya Smyczek, Pamela N. Munster, Michael S. Gordon, Weilan Ye, Heejo Baek, Junko Aimi
Publikováno v:
Cancer Research. 71:3284-3284
In this study we report the use of pharmacodynamic (PD) biomarkers to guide the clinical development of a novel antibody targeting epidermal growth factor-like domain 7 (EGFL7). EGFL7 is a secreted protein produced by endothelial cells of nascent blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29d8a49aea78761e90804c6bb766f75c
https://doi.org/10.1158/1538-7445.am2011-3284
https://doi.org/10.1158/1538-7445.am2011-3284