Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Tanya Schild"'
Autor:
Zhongchi Li, Vivien Low, Valbona Luga, Janet Sun, Ethan Earlie, Bobak Parang, Kripa Shobana Ganesh, Sungyun Cho, Jennifer Endress, Tanya Schild, Mengying Hu, David Lyden, Wenbing Jin, Chunjun Guo, Noah Dephoure, Lewis C. Cantley, Ashley M. Laughney, John Blenis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Methylmalonic acid (MMA) is increased in aging as well as produced by advanced tumors, and can drive pro-aggressive changes in these tumor cells. Here, the authors show that MMA can also act on fibroblasts in the tumor microenvironment, recruiting an
Externí odkaz:
https://doaj.org/article/f478066cc8a441dda1055be79d728377
Autor:
Didem Ilter, Stanislav Drapela, Tanya Schild, Nathan P. Ward, Emma Adhikari, Vivien Low, John Asara, Thordur Oskarsson, Eric K. Lau, Gina M. DeNicola, Melanie R. McReynolds, Ana P. Gomes
Publikováno v:
Redox Biology, Vol 61, Iss , Pp 102627- (2023)
Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism and adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance. NAD
Externí odkaz:
https://doaj.org/article/e2c33671c9844c32a8eea52be1ef6e6d
Autor:
Tanya Schild, Melanie R. McReynolds, Christie Shea, Vivien Low, Bethany E. Schaffer, John M. Asara, Elena Piskounova, Noah Dephoure, Joshua D. Rabinowitz, Ana P. Gomes, John Blenis
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109238- (2021)
Summary: Metabolic adaptations and the signaling events that control them promote the survival of pancreatic ductal adenocarcinoma (PDAC) at the fibrotic tumor site, overcoming stresses associated with nutrient and oxygen deprivation. Recently, rewir
Externí odkaz:
https://doaj.org/article/958fc6ccd56b4b52a8aeaeda92f8b4ae
Autor:
Tanya Schild, Kayvan R. Keshari
Publikováno v:
Cancer Cell. 40:1457-1458
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eb339f58bc8cc8758053cc7c8503cfa
https://doi.org/10.1016/j.ccell.2022.10.023
https://doi.org/10.1016/j.ccell.2022.10.023
Autor:
Angela Maria Savino, Briana Turner, Sangmoo Jeong, Tanya Schild, Xuejing Yang, Hanzhi Luo, Rachel Chirayil, Quinlan Cullen, Mandy Chan, Grace Han, Kathryn Chang, Sudha Janaki Raman, Justin R Cross, Kayvan Keshari, Michael G Kharas
Publikováno v:
Blood. 140:2966-2967
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77e43a7dd9a9a2c49c92841e75b04b37
https://doi.org/10.1182/blood-2022-164626
https://doi.org/10.1182/blood-2022-164626
Autor:
Zhongchi Li, Vivien Low, Valbona Luga, Janet Sun, Ethan Earlie, Bobak Parang, Kripa Shobana Ganesh, Sungyun Cho, Jennifer Endress, Tanya Schild, Menying Hu, David Lyden, Wenbing Jin, Chun-Jun Guo, Noah Dephoure, Lewis Cantley, Ashley Laughney, John Blenis
The systemic metabolic shifts that occur during aging and the local metabolic alterations of a tumor, its stroma and their communication cooperate to establish a unique tumor microenvironment (TME) that fosters cancer progression. Here, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9575aa72d5bb5e58a9b27e65aa970c0b
https://doi.org/10.21203/rs.3.rs-1643401/v1
https://doi.org/10.21203/rs.3.rs-1643401/v1
Autor:
Didem Ilter, Tanya Schild, Nathan P. Ward, Stanislav Drapela, Emma Adhikari, Vivien Low, Eric Le-Lau, Gina M. DeNicola, Melanie R. McReynolds, Ana P. Gomes
Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism to adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance. Cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae375661c9b3cc6671efd973e6335634
https://doi.org/10.1101/2022.03.25.485887
https://doi.org/10.1101/2022.03.25.485887
Autor:
Lewis C. Cantley, Rafael de Cabo, Ana P. Gomes, Julie Han, Anders P. Mutvei, Charles Kinzig, Jennifer E. Endress, Mélanie Planque, Noah Dephoure, Didem Ilter, Vivien Low, John Blenis, John M. Asara, Tanya Schild, Sarah-Maria Fendt, Edouard Mullarky, Adnan Ahmed, Ilaria Elia, Juan Fernández-García, Adam Rosenzweig, Dorien Broekaert
SummaryFrom age 65 onwards, the risk of cancer incidence and associated mortality is substantially higher1-3. Nonetheless, our understanding of the complex relationship between age and cancer is still in its infancy4. For decades, the link has largel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cf4462822fb091fe9b09e5db2d9c920
https://doi.org/10.1101/2020.06.04.135087
https://doi.org/10.1101/2020.06.04.135087
Autor:
Vivien Low, John M. Asara, Noah Dephoure, John Blenis, Ana P. Gomes, Joshua D. Rabinowitz, Melanie R. McReynolds, Tanya Schild, Christie Shea
Publikováno v:
SSRN Electronic Journal.
Metabolic adaptations and the signaling events that control them have been implicated in the adaptation of pancreatic ductal adenocarcinoma (PDAC) to survive stresses associated with nutrient and oxygen deprivation at the tumor site. Recently, rewiri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a5298ce89644dac3ebcc44a1524896a
https://doi.org/10.2139/ssrn.3515391
https://doi.org/10.2139/ssrn.3515391
Autor:
Mélanie Planque, Didem Ilter, Noah Dephoure, Lewis C. Cantley, Juan Fernández-García, Adam Rosenzweig, Adnan Ahmed, Ilaria Elia, Charles Kinzig, Edouard Mullarky, John Blenis, Tanya Schild, Dorien Broekaert, Vivien Low, Jennifer E. Endress, Sarah-Maria Fendt, John M. Asara, Rafael de Cabo, Ana P. Gomes, Julie Han, Anders P. Mutvei
Publikováno v:
Nature
The risk of cancer and associated mortality increases substantially in humans from the age of 65 years onwards1–6. Nonetheless, our understanding of the complex relationship between age and cancer is still in its infancy2,3,7,8. For decades, this l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef8ceeda67c0661bd1dbb50e451a060