Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Tanya S. McDonald"'
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 43:26-43
Neurodegeneration refers to the selective and progressive loss-of-function and atrophy of neurons, and is present in disorders such as Alzheimer’s, Huntington’s, and Parkinson’s disease. Although each disease presents with a unique pattern of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead6a428a7bde1149eab3ba91cb2498a
https://doi.org/10.1177/0271678x221135061
https://doi.org/10.1177/0271678x221135061
Autor:
Tesfaye W Tefera, Yide Wong, Mallory E Barkl-Luke, Shyuan T Ngo, Nicola K Thomas, Tanya S McDonald, Karin Borges
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161816 (2016)
There is increasing evidence that energy metabolism is disturbed in Amyotrophic Lateral Sclerosis (ALS) patients and animal models. Treatment with triheptanoin, the triglyceride of heptanoate, is a promising approach to provide alternative fuel to im
Externí odkaz:
https://doaj.org/article/dbf97d911e314c6e8d57101e5e94c161
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 40:678-691
Triheptanoin is anticonvulsant in several seizure models. Here, we investigated changes in glucose metabolism by triheptanoin interictally in the chronic stage of the pilocarpine mouse epilepsy model. After injection of [U-13C6]-glucose (i.p.), enric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8365ac6d4e37d4abd41c6e727f71488
https://doi.org/10.1177/0271678x19837380
https://doi.org/10.1177/0271678x19837380
Publikováno v:
The FASEB Journal. 35
Metabolic disturbances are associated with the progression of the neurodegenerative disorder, amyotrophic lateral sclerosis (ALS). However, the molecular events that drive energy imbalances in ALS are not completely understood. In this study, we aime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828d2158993db3c03296c40257e6b8b6
https://doi.org/10.1096/fj.202002450r
https://doi.org/10.1096/fj.202002450r
Publikováno v:
Epilepsybehavior : EB. 122
Glucose metabolism is altered in epilepsy, and this may contribute to seizure generation. Recent research has shown that metabolic therapies including the ketogenic diet and medium chain triglycerides can improve energy metabolism in the brain. Fruct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc290167c601a742fa40896213c6d4ab
https://pubmed.ncbi.nlm.nih.gov/34388666
https://pubmed.ncbi.nlm.nih.gov/34388666
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(7)
Metabolic disturbances are associated with the progression of the neurodegenerative disorder, amyotrophic lateral sclerosis (ALS). However, the molecular events that drive energy imbalances in ALS are not completely understood. In this study, we aime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d6a2b00b2dc3881d88667b2ebd8246a7
https://pubmed.ncbi.nlm.nih.gov/34118098
https://pubmed.ncbi.nlm.nih.gov/34118098
Alterations in mitochondrial glucose carbon metabolism in epilepsy and targeted metabolic treatments
Publikováno v:
Clinical Bioenergetics ISBN: 9780128196212
There is increasing evidence showing that oxidative glucose metabolism in mitochondria is impaired in epilepsy and the involved metabolic mechanisms have been further characterized by recent work. Glucose is the main energy source in brain in people
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b21fa4f58bc7daa1504469e08b7ef782
https://doi.org/10.1016/b978-0-12-819621-2.00029-2
https://doi.org/10.1016/b978-0-12-819621-2.00029-2
Publikováno v:
Molecular neurobiology. 57(10)
Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron degenerative disease that is without effective treatment. The receptor for advanced glycation end products (RAGE) is a major component of the innate immune system tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::457870560358c9a436bbcaee6ae867b5
https://pubmed.ncbi.nlm.nih.gov/32676989
https://pubmed.ncbi.nlm.nih.gov/32676989
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(6)
Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron disease without effective treatment. Although the precise mechanisms leading to ALS are yet to be determined, there is now increasing evidence implicating the defecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f129671717a6a9ebe58aa135b4f44755
https://pubmed.ncbi.nlm.nih.gov/32307753
https://pubmed.ncbi.nlm.nih.gov/32307753