Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Tanya S. Freedman"'
Autor:
Song Yi Bae, Hannah E. Bergom, Abderrahman Day, Joseph T. Greene, Zoi E. Sychev, Gabrianne Larson, Eva Corey, Stephen R. Plymate, Tanya S. Freedman, Justin H. Hwang, Justin M. Drake
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of prostate cancer. NEPC is characterized by the loss of androgen receptor (AR) signaling and transdifferentiation toward small-cell neuroendocrine (SCN) phenotypes, which results i
Externí odkaz:
https://doaj.org/article/3e48ddb167a545a593cf9fd00b156061
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The kinase Csk is the primary negative regulator of the Src-family kinases (SFKs, e.g., Lck, Fyn, Lyn, Hck, Fgr, Blk, Yes), phosphorylating a tyrosine on the SFK C-terminal tail that mediates autoinhibition. Csk also binds phosphatases, incl
Externí odkaz:
https://doaj.org/article/ce8d2dc1947c4343a6d13920a24a2a34
Autor:
Jeffrey S Miller, Martin Felices, Shee Kwan Phung, Anders W Matson, Sam Wang, Ryan R Friess, Bruce Walcheck, Kate J Dixon, Jianming Wu, Rob Hullsiek, Anders J Lindstedt, Tanya S Freedman, Emily N Truckenbrod
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background Natural killer (NK) cells are being extensively studied as a cell therapy for cancer. These cells are activated by recognition of ligands and antigens on tumor cells. Cytokine therapies, such as IL-15, are also broadly used to stimulate en
Externí odkaz:
https://doaj.org/article/5e8cbf8ebe014603ad1dd5faf7ed4016
Autor:
Damien M Rasmussen, Manny M Semonis, Joseph T Greene, Joseph M Muretta, Andrew R Thompson, Silvia Toledo Ramos, David D Thomas, William CK Pomerantz, Tanya S Freedman, Nicholas M Levinson
Publikováno v:
eLife, Vol 13 (2024)
The type II class of RAF inhibitors currently in clinical trials paradoxically activate BRAF at subsaturating concentrations. Activation is mediated by induction of BRAF dimers, but why activation rather than inhibition occurs remains unclear. Using
Externí odkaz:
https://doaj.org/article/908aea3f4eb7430b8ef82e94417a536d
Publikováno v:
Curr Opin Immunol
Myeloid cells (macrophages, monocytes, dendritic cells, and granulocytes) survey the body for signs of infection and tissue damage and regulate tissue homeostasis, organogenesis, and immunity. They express receptors that initiate the inflammatory res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356e5544f396e229cdcd7f87930f4729
https://doi.org/10.1016/j.coi.2021.09.004
https://doi.org/10.1016/j.coi.2021.09.004
Autor:
Anna S. Jaeger, Chelsea M. Crooks, Andrea M. Weiler, Mason I. Bliss, Sierra Rybarczyk, Alex Richardson, Morgan Einwalter, Eric Peterson, Saverio Capuano, Alison Barkhymer, Jordan T. Becker, Joseph T. Greene, Tanya S. Freedman, Ryan A. Langlois, Thomas C. Friedrich, Matthew T. Aliota
Spondweni virus (SPONV) is the closest known relative of Zika virus (ZIKV). SPONV pathogenesis resembles that of ZIKV in pregnant mice, and both viruses are transmitted byAedes aegyptimosquitoes. We aimed to develop a translational model to further u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ef5a09d6a66444880fd070933b6fec4
https://doi.org/10.1101/2022.12.16.520792
https://doi.org/10.1101/2022.12.16.520792
Autor:
Ben F. Brian, Monica L. Sauer, Joseph T. Greene, S. Erandika Senevirathne, Anders J. Lindstedt, Olivia L. Funk, Brian L. Ruis, Luis A. Ramirez, Jennifer L. Auger, Whitney L. Swanson, Myra G. Nunez, Branden S. Moriarity, Clifford A. Lowell, Bryce A. Binstadt, Tanya S. Freedman
Publikováno v:
Science advances, vol 8, iss 16
Here, we report that the LynB splice variant of the Src-family kinase Lyn exerts a dominant immunosuppressive function in vivo, whereas the LynA isoform is uniquely required to restrain autoimmunity in female mice. We used CRISPR-Cas9 gene editing to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79a31ea6ce138ddaa264f5f1d06771d
https://escholarship.org/uc/item/4pr231mw
https://escholarship.org/uc/item/4pr231mw
Autor:
Tanya S. Freedman, Ben F Brian
Publikováno v:
Endocrinology
Effective regulation of immune-cell activation is critical for ensuring that the immune response, and inflammation generated for the purpose of pathogen elimination, are limited in space and time to minimize tissue damage. Autoimmune disease can occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea79a7a7fb036a691cfa098248dab1b
https://doi.org/10.1210/endocr/bqab152
https://doi.org/10.1210/endocr/bqab152
Autor:
Will Swanson, Senevirathne Se, Myra G. Nunez, Tanya S. Freedman, Brian L. Ruis, Ben F Brian, Binstadt Ba, Branden S. Moriarity, Sauer Ml, Auger Jl, Clifford A. Lowell
The unique roles of the Src-family kinases LynA and LynB in immune activating and inhibitory signaling have eluded definition. Here we report that LynB, the shorter splice product of lyn, carries the dominant immunosuppressive function. We used CRISP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf903a9d59a6a1bfce9fae9d3c437179
https://doi.org/10.1101/2021.05.03.439514
https://doi.org/10.1101/2021.05.03.439514
Publikováno v:
Current Protocols in Immunology
In this article we describe the use of pharmacological and genetic tools coupled with immunoblotting (Western blotting) and targeted mass spectrometry to quantify immune signaling and cell activation mediated by tyrosine kinases. Transfer of the ATP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2bb2695391d526c7acc33cba503698
https://doi.org/10.1002/cpim.104
https://doi.org/10.1002/cpim.104