The quantitative architecture of centromeric chromatin

Autor: Dani L Bodor, João F Mata, Mikhail Sergeev, Ana Filipa David, Kevan J Salimian, Tanya Panchenko, Don W Cleveland, Ben E Black, Jagesh V Shah, Lars ET Jansen

Publikováno v: eLife, Vol 3 (2014)

The centromere, responsible for chromosome segregation during mitosis, is epigenetically defined by CENP-A containing chromatin. The amount of centromeric CENP-A has direct implications for both the architecture and epigenetic inheritance of centrome

Externí odkaz: https://doaj.org/article/974d5ffd5ef4400b878f5e6af958c8c0

Phosphorylation of the ancestral histone variant H3.3 amplifies stimulation-induced transcription

Autor: Shu Lin, Tanya Panchenko, Sandra B. Hake, Andrew W Daman, Jin Q Jeong, Alexia Martínez de Paz, C. David Allis, Benjamin A. Garcia, Ceyda Durmaz, Shuang Yang, Arjun Ravishankar, Haitao Li, Anja Armache, Tanja Arslan, Lexi E. Robbins, Steven Z. Josefowicz

Complex organisms are able to rapidly induce select genes among thousands in response to diverse environmental cues. This occurs in the context of large genomes condensed with histone proteins into chromatin. The macrophage response to pathogen sensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefa96411993801af6dd73ebd3bd4cf8
https://doi.org/10.1101/808048

Both tails and the centromere targeting domain of CENP-A are required for centromere establishment

Autor: Lucie Y. Guo, Jamie E. DeNizio, Jennine M. Dawicki-McKenna, Ben E. Black, Evelyne J. Barrey, Glennis A. Logsdon, Emily A. Bassett, Tanya Panchenko, Patrick Heun

Publikováno v: The Journal of Cell Biology
Logsdon, G A, Barrey, E J, Bassett, E A, DeNizio, J E, Guo, L Y, Panchenko, T, Dawicki-McKenna, J M, Heun, P & Black, B E 2015, ' Both tails and the centromere targeting domain of CENP-A are required for centromere establishment ', Journal of Cell Biology, vol. 208, no. 5, pp. 521-531 . https://doi.org/10.1083/jcb.201412011

New roles for the N-terminal histone tail and folded core of CENP-A are revealed by monitoring early steps in centromere establishment.
The centromere—defined by the presence of nucleosomes containing the histone H3 variant, CENP-A—is the ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75cee8a1af0117b303591622976bb92
https://doi.org/10.1083/jcb.201412011

The octamer is the major form of CENP-A nucleosomes at human centromeres

Autor: Ben E. Black, Nikolina Sekulic, Tanya Panchenko, Peter E. Warburton, Alicia Alonso, Kevan J. Salimian, Mishah Uzziel Salman, Dan Hasson

Publikováno v: Nature structural & molecular biology

The centromere is the chromosomal locus that ensures fidelity in genome transmission at cell division. Centromere protein A (CENP-A) is a histone H3 variant that specifies centromere location independently of DNA sequence. Conflicting evidence has em

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf87a0f45d0c40333c755d6963348e0
https://doi.org/10.1038/nsmb.2562

Replacement of histone H3 with CENP-A directs global nucleosome array condensation and loosening of nucleosome superhelical termini

Autor: Zhong-yuan Kan, Tanya Panchenko, Troy C. Sorensen, Michael G. Resch, Ben E. Black, Christopher L. Woodcock, Stacey Wood, Jeffrey C. Hansen, S. Walter Englander, Karolin Luger

Publikováno v: Proceedings of the National Academy of Sciences. 108:16588-16593

Centromere protein A (CENP-A) is a histone H3 variant that marks centromere location on the chromosome. To study the subunit structure and folding of human CENP-A-containing chromatin, we generated a set of nucleosomal arrays with canonical core hist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6234812553c97cccfc9095d511054e61
https://doi.org/10.1073/pnas.1113621108