Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Tanya N. Mayadas"'
Autor:
Vijayashree Mysore, Xavier Cullere, Joseph Mears, Florencia Rosetti, Koshu Okubo, Pei X. Liew, Fan Zhang, Iris Madera-Salcedo, Frank Rosenbauer, Richard M. Stone, Jon C. Aster, Ulrich H. von Andrian, Andrew H. Lichtman, Soumya Raychaudhuri, Tanya N. Mayadas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
Neutrophils are versatile immune cells that may also serve as antigen-presenting cells (APC). Here the authors show that engaging FcγRs on neutrophils with immune complexes or an anti-FcγR-antigen conjugate induces neutrophil APC with comparable fu
Externí odkaz:
https://doaj.org/article/86a5a1c6c18f436081a1927c18c8de2d
Autor:
Artem Vorobyev, Yask Gupta, Tanya Sezin, Hiroshi Koga, Yannic C. Bartsch, Meriem Belheouane, Sven Künzel, Christian Sina, Paul Schilf, Heiko Körber-Ahrens, Foteini Beltsiou, Anna Lara Ernst, Stanislav Khil’chenko, Hassanin Al-Aasam, Rudolf A. Manz, Sandra Diehl, Moritz Steinhaus, Joanna Jascholt, Phillip Kouki, Wolf-Henning Boehncke, Tanya N. Mayadas, Detlef Zillikens, Christian D. Sadik, Hiroshi Nishi, Marc Ehlers, Steffen Möller, Katja Bieber, John F. Baines, Saleh M. Ibrahim, Ralf J. Ludwig
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Complex traits associate with genetic variation and environment and their interaction. Here, the authors study the influence of different diets on trait variability in 1154 outbred mice from an advanced intercross line and find gene-diet interactions
Externí odkaz:
https://doaj.org/article/33aa09018c92411598dc61043de133d0
Autor:
Koshu Okubo, Michael D. Brenner, Xavier Cullere, Gurpanna Saggu, Myra L. Patchen, Nandita Bose, Saki Mihori, Zhou Yuan, Clifford A. Lowell, Cheng Zhu, Tanya N. Mayadas
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109142- (2021)
Summary: The interaction of the human FcγRIIA with immune complexes (ICs) promotes neutrophil activation and thus must be tightly controlled to avoid damage to healthy tissue. Here, we demonstrate that a fungal-derived soluble β-1,3/1,6-glucan bind
Externí odkaz:
https://doaj.org/article/9a4ac42e04014a60b236ae9a01a774d1
Autor:
Gurpanna Saggu, Koshu Okubo, Yunfeng Chen, Ravi Vattepu, Naotake Tsuboi, Florencia Rosetti, Xavier Cullere, Nathaniel Washburn, Suhail Tahir, Aaron M. Rosado, Steven M. Holland, Robert M. Anthony, Mehmet Sen, Cheng Zhu, Tanya N. Mayadas
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Deposited immune complexes (IC) promote neutrophil recruitment, but the fine tuning of this process is still unclear. Here the authors show that the cis interaction of the IC receptor, FcγRIIA and CD18 integrin, Mac-1, on the neutrophil surface modu
Externí odkaz:
https://doaj.org/article/94c549222fd542cf9308dbd596a1cb4c
Autor:
Nobuya Yoshida, Denis Comte, Masayuki Mizui, Kotaro Otomo, Florencia Rosetti, Tanya N. Mayadas, José C. Crispín, Sean J. Bradley, Tomohiro Koga, Michihito Kono, Maria P. Karampetsou, Vasileios C. Kyttaris, Klaus Tenbrock, George C. Tsokos
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
ICER is a CREM splice variant that represses CREM/CREB signalling. Here the authors use human cells and mouse models of various autoimmune diseases to show that ICER is central to pathogenic Th17 cell differentiation in autoimmunity.
Externí odkaz:
https://doaj.org/article/20f648b03a354e689528b9b09bfaa39f
Autor:
Konrad Buscher, Huiyu Wang, Xueli Zhang, Paul Striewski, Benedikt Wirth, Gurpanna Saggu, Stefan Lütke-Enking, Tanya N. Mayadas, Klaus Ley, Lydia Sorokin, Jian Song
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Neutrophils are critical in preventing the transition of acute peritoneal infection to sepsis. Here the authors show in three mouse models of peritonitis that neutrophils enter the abdominal cavity via high endothelial venules of the greater omentum,
Externí odkaz:
https://doaj.org/article/15cfcd382e7148ceb82297fa2012f9df
Autor:
Florencia Rosetti, Yunfeng Chen, Mehmet Sen, Elizabeth Thayer, Veronica Azcutia, Jan M. Herter, F. William Luscinskas, Xavier Cullere, Cheng Zhu, Tanya N. Mayadas
Publikováno v:
Cell Reports, Vol 10, Iss 10, Pp 1655-1664 (2015)
Leukocyte CD18 integrins increase their affinity for ligand by transmitting allosteric signals to and from their ligand-binding αI domain. Mechanical forces induce allosteric changes that paradoxically slow dissociation by increasing the integrin/li
Externí odkaz:
https://doaj.org/article/49f6f64ac97e41968bfc3bdb8580eafe
Autor:
Pascal Yazbeck, Xavier Cullere, Paul Bennett, Vijay Yajnik, Huan Wang, Kenji Kawada, Vanessa M. Davis, Asit Parikh, Andrew Kuo, Vijayashree Mysore, Timothy Hla, David S. Milstone, Tanya N. Mayadas
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42:886-902
Background: The vascular endothelium maintains tissue-fluid homeostasis by controlling the passage of large molecules and fluid between the blood and interstitial space. The interaction of catenins and the actin cytoskeleton with VE-cadherin (vascula
Autor:
Xavier Cullere, Soumya Raychaudhuri, Florencia Rosetti, Frank Rosenbauer, Richard Stone, Fan Zhang, Ulrich H. von Andrian, Andrew H. Lichtman, Joseph R. Mears, Koshu Okubo, Tanya N. Mayadas, Jon C. Aster, Vijayashree Mysore, Iris K. Madera-Salcedo, Pei X. Liew
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
Classical dendritic cells (cDC) are professional antigen-presenting cells (APC) that regulate immunity and tolerance. Neutrophil-derived cells with properties of DCs (nAPC) are observed in human diseases and after culture of neutrophils with cytokine
Autor:
Tal Gilboa, Blythe Durbin-Johnson, Vijayashree Mysore, Tanya N. Mayadas, Matthew L. Settles, Lindsey R. Baden, Andrew H. Lichtman, Xinge Ji, Lara Jehi, Xavier Cullere, David R. Walt, Michael W. Kattan, Michaël Desjardins
Publikováno v:
Med (New York, N.y.)
Summary Background T cells control viral infection, promote vaccine durability, and in coronavirus disease 2019 (COVID-19) associate with mild disease. We investigated whether prior measles-mumps-rubella (MMR) or tetanus-diphtheria-pertussis (Tdap) v