Výsledky vyhledávání - "Tanya L. Poshusta"

Akademický článek

Mutations in specific structural regions of immunoglobulin light chains are associated with free light chain levels in patients with AL amyloidosis.

Autor: Tanya L Poshusta, Laura A Sikkink, Nelson Leung, Raynell J Clark, Angela Dispenzieri, Marina Ramirez-Alvarado

Publikováno v: PLoS ONE, Vol 4, Iss 4, p e5169 (2009)

The amyloidoses are protein misfolding diseases characterized by the deposition of amyloid that leads to cell death and tissue degeneration. In immunoglobulin light chain amyloidosis (AL), each patient has a unique monoclonal immunoglobulin light cha

Externí odkaz: https://doaj.org/article/36b4d2a48f9546a7aa292f8b03d32067

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A primer genetic toolkit for exploring mitochondrial biology and disease using zebrafish

Autor: Noriko Ichino, Jarryd M. Campbell, Wiebin Liu, Zachary WareJoncas, Tanya L. Poshusta, Karl J. Clark, Xiaolei Xu, Mark D. Urban, Mark D Wishman, Jake D. Bergren, Rhianna M. Urban, Stephen C. Ekker, Ankit Sabharwal, Hirotaka Ata, Yonghe Ding

Mitochondria are a dynamic eukaryotic innovation that play diverse roles in biology and disease. The mitochondrial genome is remarkably conserved in all vertebrates, encoding the same 37 gene set and overall genomic structure ranging from 16,596 base

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fadf989286d11573f2b754dfd090a0e

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Forward Genetic Screening Using Behavioral Tests in Zebrafish: A Proof of Concept Analysis of Mutants

Autor: Tanya L. Poshusta, Eric W. Klee, Karl J. Clark, Tammy M. Greenwood, Margot A. Cousin, Robert Gerlai, Yohaan Fernandes, Mindy Rampersad

Publikováno v: Behavior Genetics. 47:125-139

The zebrafish enjoys several advantages over other model organisms. It is small, easy to maintain, prolific, and numerous genetic tools are available for it. For example, forward genetic screens have allowed investigators to identify important genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21cbf657f4e8617a6f781ab87f5ae19
https://doi.org/10.1007/s10519-016-9818-y

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A transgenic zebrafish model for monitoring glucocorticoid receptor activity

Autor: Randall G. Krug, Karl J. Clark, Tanya L. Poshusta, Samantha L. Gardner, Kimberly J. Skuster, MaKayla R. Berg

Publikováno v: Genes, Brain and Behavior. 13:478-487

Gene regulation resulting from glucocorticoid receptor and glucocorticoid response element interactions is a hallmark feature of stress response signaling. Imbalanced glucocorticoid production and glucocorticoid receptor activity have been linked to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffa2956baec8f4b1d6249666ac7fb017
https://doi.org/10.1111/gbb.12135

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Thermal Stability Threshold for Amyloid Formation in Light Chain Amyloidosis

Autor: Nagaaki Katoh, Tanya L. Poshusta, Marina Ramirez-Alvarado, Morie A. Gertz, Angela Dispenzieri

Publikováno v: International Journal of Molecular Sciences, Vol 14, Iss 11, Pp 22604-22617 (2013)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 14; Issue 11; Pages: 22604-22617

Light chain (AL) amyloidosis is a devastating disease characterized by amyloid deposits formed by immunoglobulin light chains. Current available treatments involve conventional chemotherapy and autologous stem cell transplant. We have recently conclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3db35117efdda6143988e0b6e014cb7
http://www.mdpi.com/1422-0067/14/11/22604

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FusX: A Rapid One-Step Transcription Activator-Like Effector Assembly System for Genome Science

Autor: Patrick R. Blackburn, Jarryd M. Campbell, Mark D. Urban, Toni K. Man, David P. Argue, Alvin C.H. Ma, Stephen C. Ekker, Cassandra E. Bullard, Gabriel Martínez-Gálvez, Tanya L. Poshusta, Karl J. Clark, Melissa S. McNulty, Han B. Lee

Publikováno v: Human Gene Therapy

Transcription activator-like effectors (TALEs) are extremely effective, single-molecule DNA-targeting molecular cursors used for locus-specific genome science applications, including high-precision molecular medicine and other genome engineering appl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1869cc8bd28a8bf87bc918ca57921a1
https://pubmed.ncbi.nlm.nih.gov/26854857

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In vivo genome editing using a high-efficiency TALEN system

Autor: Alvin C.H. Ma, Scott C. Fahrenkrug, Stephen C. Ekker, Sumedha G. Penheiter, Daniel F. Carlson, Anskar Y.H. Leung, Randall G. Krug, Jarryd M. Campbell, Karl J. Clark, Jeffrey J. Essner, Victoria M. Bedell, Daniel F. Voytas, Ying Wang, Tanya L. Poshusta, Wenfang Tan, Colby G. Starker

Publikováno v: Nature. 491:114-118

The zebrafish (Danio rerio) is increasingly being used to study basic vertebrate biology and human disease with a rich array of in vivo genetic and molecular tools. However, the inability to readily modify the genome in a targeted fashion has been a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8692b8ea4cb8d18552236aba176375ca
https://doi.org/10.1038/nature11537

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A Reappraisal of Immunoglobulin Variable Gene Primers and Its Impact on Assessing Clonal Relationships Between PB B Cells and BM Plasma Cells in AL Amyloidosis

Autor: Nagaaki Katoh, Morie A. Gertz, Marina Ramirez-Alvarado, Tanya L. Poshusta, Michelle K. Manske, Angela Dispenzieri, Roshini S. Abraham

Publikováno v: Journal of Clinical Immunology. 31:1029-1037

Monoclonal tumor plasma cells as well as non-terminally differentiated B cells having a clonal relationship to the tumor cells have been detected in the peripheral blood (PB) of some multiple myeloma (MM) patients but rarely in light chain (primary s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fdc65e0e9206aee39ef15aa9b3c895
https://doi.org/10.1007/s10875-011-9582-y

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GoldyTALEN Vectors with Improved Efficiency for Golden Gate TALEN Assembly

Autor: Stephen C. Ekker, Maura McGrail, Melissa S. McNulty, Jordan M. Welker, Karl J. Clark, Wesley A. Wierson, Staci L. Solin, Jeffery J. Essner, Ying Wang, Ellen E. Tisdale, Tanya L. Poshusta

Publikováno v: Human Gene Therapy. 27:423-424

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954088d18c8622588a242805dd926f93
https://doi.org/10.1089/hum.2016.012

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Renal failure due to combined cast nephropathy, amyloidosis and light-chain deposition disease

Autor: Fernando C. Fervenza, Marina Ramirez-Alvarado, Shaji Kumar, Tanya L. Poshusta, Nelson Leung, Sanjeev Sethi, Elizabeth C. Lorenz, Donna J. Lager

Publikováno v: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 25(4)

Renal dysfunction commonly occurs in multiple myeloma (MM) and is caused by deposition of abnormal light chain within various compartments of the kidney. Renal pathologic findings are diverse and include cast nephropathy (CN), amyloidosis and light-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce7755d73ae2fff211c208a635ad0d99
https://pubmed.ncbi.nlm.nih.gov/20061318

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