Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tanya Guha"'
Autor:
Vallijah Subasri, Benjamin Brew, Lauren Erdman, Tanya Guha, Jordan R. Hansford, Elizabeth Cairney, Carol Portwine, Christine Elser, Jonathan L. Finlay, Kim E. Nichols, Wendy Kohlmann, Noa Alon, Ana Novokmet, Ledia Brunga, Anita Villani, Kelvin C. de Andrade, Payal P. Khincha, Sharon A. Savage, Joshua D. Schiffman, David Malkin, Anna Goldenberg
Publikováno v:
Cancer Research. 82:1428-1428
Background: Li-Fraumeni syndrome (LFS) is an autosomal dominant cancer predisposition syndrome. Approximately 80% of individuals with LFS harbor a germline TP53 pathogenic variant rendering them susceptible to a wide spectrum of early-onset malignanc
Publikováno v:
Pediatric bloodcancerREFERENCES. 67(12)
Liquid biopsy, specifically circulating tumor DNA (ctDNA) detection, has started to revolutionize the clinical management of patients with cancer by surpassing many limitations of traditional tissue biopsies, particularly for serial testing. ctDNA se
Autor:
Cynthia Hawkins, Christian Thomas, Diana M. Merino, Michael Brudno, Eric Bouffet, Tanya Guha, David Malkin, Adam Shlien, Jonathan L. Finlay, Sanaa Choufani, Rosanna Weksberg, Martin Sill, Richard J. Gilbertson, Martin Hasselblatt, David Capper, Andrei L. Turinsky, Uri Tabori, Nada Jabado, Malgorzata Pienkowska, Ana Novokmet
Publikováno v:
Clinical Epigenetics
Histological grading of choroid plexus tumors (CPTs) remains the best prognostic tool to distinguish between aggressive choroid plexus carcinoma (CPC) and the more benign choroid plexus papilloma (CPP) or atypical choroid plexus papilloma (aCPP); how
Autor:
Badr Id Said, Tanya Guha, David Malkin, Anne-Lise Børrsen-Dale, Weili Li, Nardin Samuel, Laxmi Silwal-Pandit, Anita Langerød, Thomas J Hudson, Ana Novokmet
Publikováno v:
Human Mutation. 38:265-268
Germline polymorphic variants in cancer predisposition genes such as TP53 have been shown to impact the risk of premenopausal cancer. Accordingly, the aim of this study was to assess the spectrum of polymorphisms in TP53 and its negative regulatory g
Autor:
Michael Brudno, Jonathan L. Finlay, Andrei L. Turinsky, Rosanna Weksberg, Martin Sill, Christian Thomas, Sanaa Choufani, Uri Tabori, Eric Bouffet, Nada Jabado, Cynthia Hawkins, Malgorzata Pienkowska, Adam Shlien, David Capper, Diana M. Merino, Ana Novokmet, Tanya Guha, Richard J. Gilbertson, Martin Hasselblatt, David Malkin
Publikováno v:
Clinical Epigenetics
Background Histological grading of choroid plexus tumors (CPTs) remains the best prognostic tool to distinguish between aggressive choroid plexus carcinoma (CPC) and the more benign choroid plexus papilloma (CPP) or atypical choroid plexus papilloma
Autor:
Tanya Guha, David Malkin
Li-Fraumeni syndrome (LFS) is a complex hereditary cancer predisposition disorder associated with early-onset cancers in diverse tissues of origin. Germline TP53 mutations are identified in 75% of patients with classic LFS. The lifetime likelihood of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d289d6dcd7f328083d27954e2a4f1813
https://europepmc.org/articles/PMC5378014/
https://europepmc.org/articles/PMC5378014/
Autor:
Anna Goldenberg, Lauren Erdman, David Malkin, Andrea Doria, Benjamin Brew, Tanya Guha, Adam Shlien, Jason N. Berman, Ana Novokmet
Publikováno v:
Cancer Research. 77:973-973
Introduction: Li Fraumeni Syndrome (LFS) is a rare hereditary genetic cancer predisposition syndrome. Germline mutations of the TP53 tumor suppressor gene are the underlying cause in >80% of patients with LFS, and are associated with an increased ris
Publikováno v:
Cancer Research. 77:2741-2741
Li-Fraumeni Syndrome (LFS) is a hereditary cancer predisposition syndrome commonly characterized by the presence of inherited mutations in the tumor suppressor gene TP53. This leads to an early onset of a wide spectrum of tumors in multiple organ sys
Autor:
Pienkowska, Malgorzata1 (AUTHOR), Choufani, Sanaa1 (AUTHOR), Turinsky, Andrei L.1,2 (AUTHOR), Guha, Tanya1 (AUTHOR), Merino, Diana M.3 (AUTHOR), Novokmet, Ana1 (AUTHOR), Brudno, Michael1,2,4 (AUTHOR), Weksberg, Rosanna1,5,6 (AUTHOR), Shlien, Adam1,7 (AUTHOR), Hawkins, Cynthia1,7 (AUTHOR), Bouffet, Eric6,8 (AUTHOR), Tabori, Uri1,6,8 (AUTHOR), Gilbertson, Richard J.9 (AUTHOR), Finlay, Jonathan L.10 (AUTHOR), Jabado, Nada11 (AUTHOR), Thomas, Christian12 (AUTHOR), Sill, Martin13,14 (AUTHOR), Capper, David15,16 (AUTHOR), Hasselblatt, Martin12 (AUTHOR), Malkin, David1,6,8,17 (AUTHOR) david.malkin@sickkids.ca
Publikováno v:
Clinical Epigenetics. 10/21/2019, Vol. 11 Issue 1, pN.PAG-N.PAG. 1p.
Autor:
Curtis, Jeffrey R., Kunihiro Yamaoka, Yi-Hsing Chen, Bhatt, Deepak L., Gunay, Levent M., Naonobu Sugiyama, Connell, Carol A., Cunshan Wang, Wu, Joseph, Menon, Sujatha, Vranic, Ivana, Gómez-Reino, Juan J.
Publikováno v:
Annals of the Rheumatic Diseases; Mar2023, Vol. 82 Issue 3, p331-343, 13p