Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Tanya Comas"'
Autor:
Marzia Martina, Umberto Banderali, Alvaro Yogi, Mehdi Arbabi Ghahroudi, Hong Liu, Traian Sulea, Yves Durocher, Greg Hussack, Henk van Faassen, Balu Chakravarty, Qing Yan Liu, Umar Iqbal, Binbing Ling, Etienne Lessard, Joey Sheff, Anna Robotham, Debbie Callaghan, Maria Moreno, Tanya Comas, Dao Ly, Danica Stanimirovic
Publikováno v:
Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)
Abstract Genetic studies have identified the voltage‐gated sodium channel 1.7 (Nav1.7) as pain target. Due to the ineffectiveness of small molecules and monoclonal antibodies as therapeutics for pain, single‐domain antibodies (VHHs) are developed
Externí odkaz:
https://doaj.org/article/25473da9710e4c68b7eed6b4056350ba
Autor:
Melissa Hewitt, Amy Aylsworth, Tanya Comas, Vincent Marleau, Yanouchka Rouleau, Evelyn C. Soo, Willard J. Costain, Ingrid Rasquinha, Joseph S. Tauskela
Publikováno v:
European journal of pharmacology. 823
Synthetic cannabinoids are marketed as legal alternatives to Δ9-THC, and are a growing worldwide concern as these drugs are associated with severe adverse effects. Unfortunately, insufficient information regarding the physiological and pharmacologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7882a9113372d0e781414b26105a19
https://pubmed.ncbi.nlm.nih.gov/29408093
https://pubmed.ncbi.nlm.nih.gov/29408093
Autor:
Willard J. Costain, Marzia Martina, Melissa Hewitt, Amy Aylsworth, Tanya Comas, Xigeng Zhao, Joseph S. Tauskela
Publikováno v:
European journal of pharmacology. 786
Activation of cannabinoid receptor 1 (CB1) inhibits synaptic transmission in hippocampal neurons. The goal of this study was to evaluate the ability of benchmark and emerging synthetic cannabinoids to suppress neuronal activity in vitro using two com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9edf0273de2c8cd109e284ed678166
https://pubmed.ncbi.nlm.nih.gov/27262380
https://pubmed.ncbi.nlm.nih.gov/27262380
Publikováno v:
Drug Development Research. 68:84-93
Technological limitations have restricted the ability to determine chronic drug effects on synaptic function from in vitro preparations. In earlier studies, the extracellular recording duration was limited to less than 10 h and only a distinct popula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04746abfec76d5a222e138aed5eccd71
https://doi.org/10.1002/ddr.20170
https://doi.org/10.1002/ddr.20170
Publikováno v:
American Journal of Physiology-Cell Physiology. 285:C899-C911
Transient exposure of rat cortical cultures to nonlethal oxygen-glucose deprivation (OGD preconditioning) induces tolerance to otherwise lethal oxygen-glucose deprivation (OGD) or N-methyl-d-aspartate 24 h later. This study evaluates the role of cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6eae14b49c4cdc9f2caeb24df4153f
https://doi.org/10.1152/ajpcell.00110.2003
https://doi.org/10.1152/ajpcell.00110.2003
Autor:
Mike W. Denhoff, Anthony Krantis, Christophe Py, Geoffrey A.R. Mealing, Tanya Comas, Robert Monette, Dolores Martinez
We present a dry lift-off method using a chemically resistant spin-on plastic, polyimide, to pattern surfaces with high accuracy and resolution. Using well-known lithographic and reactive ion etching techniques, the spin-on polymer is patterned over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67559b00aa190fbd3c305cf883b5018
https://doi.org/10.1002/bit.24887
https://doi.org/10.1002/bit.24887
Autor:
Tania F. Gendron, Paul Morley, Tanya Comas, Antoine M. Hakim, Li Ping Kang, Kimberley Hewitt, Jon P. Durkin, Matthew J. Hogan, Joseph S. Tauskela
Publikováno v:
Glia. 30:329-341
The sensitivity of six fluorophores to glutathione (GSH) was evaluated in living rat cortical neuronal/glial mixed cultures during the first 23 days in vitro (DIV). Four of the dyes require glutathione-S-transferase (GST) to form a fluorescent conjug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84f81fefa87f331b95d962aae6763509
https://doi.org/10.1002/(sici)1098-1136(200006)30:4<329::aid-glia20>3.0.co
https://doi.org/10.1002/(sici)1098-1136(200006)30:4<329::aid-glia20>3.0.co
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 4 (2013)
Frontiers in Pharmacology, Vol 4 (2013)
The hippocampus is a complex network tightly regulated by interactions between excitatory and inhibitory neurons. In neurodegenerative disorders where cognitive functions such as learning and memory are impaired this excitation-inhibition balance may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddb82e35113dbe90d2ba2f381bce0b7
http://europepmc.org/articles/PMC3595640
http://europepmc.org/articles/PMC3595640
Autor:
Anthony Krantis, Tanya Comas, Christophe Py, Geoffrey A.R. Mealing, Christy Maynard, Robert Monette, Gerardo A. Diaz-Quijada
We are currently developing multisite planar patch-clamp chips capable of recording high resolution electrophysiological function from individual neurons established in culture. This capability provides a unique opportunity to establish and study com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b53f8917be5ff1cc71e1a62f3b675aa
https://nrc-publications.canada.ca/eng/view/object/?id=3a789b96-409a-4731-aae0-e0d42535b418
https://nrc-publications.canada.ca/eng/view/object/?id=3a789b96-409a-4731-aae0-e0d42535b418
Autor:
Tanya Comas, Laura Kremer, Marzia Martina, Christophe Py, Geoff Mealing, Danish Salim, Mike W. Denhoff, Dolores Martinez, Robert Monette
We have previously described the designs of two planar patch-clamp neurochips and their application to the electrophysiological study of molluscan neurons cultured on-chip. Neuron attachment and growth over apertures on the neurochip surface permitte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b06f672bc0a3ecab3ef8a0985fa4b76
https://nrc-publications.canada.ca/eng/view/object/?id=fed3f356-458d-4def-88b1-0531e5c6d26b
https://nrc-publications.canada.ca/eng/view/object/?id=fed3f356-458d-4def-88b1-0531e5c6d26b