Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Tanya Coleman"'
Autor:
Teresa Klinowska, A. Nigel Brooks, Martine J. Mellor, Dawn Baker, Tanya Coleman, Claire Rooney, Sarah Beck, Katherine Al-Kadhimi, Andrew P. Thomas, Elaine Kilgour, Lorraine Mooney, Paul R. Gavine
PDF file - 59K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02213894491e67917b3e347e953da234
https://doi.org/10.1158/0008-5472.22392936
https://doi.org/10.1158/0008-5472.22392936
Autor:
Teresa Klinowska, A. Nigel Brooks, Martine J. Mellor, Dawn Baker, Tanya Coleman, Claire Rooney, Sarah Beck, Katherine Al-Kadhimi, Andrew P. Thomas, Elaine Kilgour, Lorraine Mooney, Paul R. Gavine
PDF file - 68K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886531cf0c0a13a68c9efa2f2f894980
https://doi.org/10.1158/0008-5472.22392942
https://doi.org/10.1158/0008-5472.22392942
Autor:
Teresa Klinowska, A. Nigel Brooks, Martine J. Mellor, Dawn Baker, Tanya Coleman, Claire Rooney, Sarah Beck, Katherine Al-Kadhimi, Andrew P. Thomas, Elaine Kilgour, Lorraine Mooney, Paul R. Gavine
PDF file - 52K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3315d3cde92acedb6d8efb3a36412d
https://doi.org/10.1158/0008-5472.22392933.v1
https://doi.org/10.1158/0008-5472.22392933.v1
Autor:
Teresa Klinowska, A. Nigel Brooks, Martine J. Mellor, Dawn Baker, Tanya Coleman, Claire Rooney, Sarah Beck, Katherine Al-Kadhimi, Andrew P. Thomas, Elaine Kilgour, Lorraine Mooney, Paul R. Gavine
PDF file - 61K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17bdde4e6b96a9dd10c12c36eddf49ba
https://doi.org/10.1158/0008-5472.22392939.v1
https://doi.org/10.1158/0008-5472.22392939.v1
Autor:
Neil Upton, Tania O. Stean, Claire Roberts, Michael S. Hadley, Vicky Holland, Gary W. Price, Laurie J. Gordon, Jeannette M. Watson, Jenifer Powles, Claire M. Scott, Leanne Cutler, Tanya Coleman, Tom D. Heightman, Andrew Ayrton, Jean-Pierre Pilleux, Sarah L. Pardoe, Graham J. Riley, Laramie Mary Gaster, Nigel E. Austin, Brenda K. Trail, Derek N. Middlemiss
The novel 8-piperazinyl-2,3-dihydropyrroloisoquinoline template was synthesized in nine steps. The template was N-substituted to give a series of compounds showing binding to human cloned 5-HT1A, 5-HT1B and 5-HT1D receptors with pKi’s greater than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86421f00e16772e71fb543436a7895c9
https://doi.org/10.1016/j.bmcl.2005.06.042
https://doi.org/10.1016/j.bmcl.2005.06.042
Publikováno v:
Drug Metabolism and Disposition. 37:391-399
The impact of transport proteins in the disposition of chemicals is becoming increasingly evident. Alteration in disposition can cause altered pharmacokinetic and pharmacodynamic parameters, potentially leading to reduced efficacy or overt toxicity.
Publikováno v:
British Journal of Pharmacology. 154:246-255
Background and purpose: Oral drug bioavailability is limited by intestinal expression of P-glycoprotein (MDR1, Pgp, ABCB1) whose capacity is regulated via nuclear receptors e.g. the pregnane X receptor (PXR, SXR, NR1I2). In order to study dynamic reg
Autor:
Gerard Martin Paul Giblin, Anton D. Michel, Adrian Hall, Riccardo Novelli, Matthew R. Johnson, Alan Naylor, Susan H. Brown, David J. Spalding, Nicholas Maughan Clayton, Mark Patrick Healy, Anita Chowdhury, Jennifer Sweeting, Iain P. Chessell, Tanya Coleman, Beverley Hammond, Ann Metcalf
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:732-735
This paper details the SAR of 1,5-biaryl pyrrole derivatives with substituents in the 2-, 4-, and 5-positions of the benzoic acid group as EP1 receptor antagonists. Substitution at the 2-position was poorly tolerated, whereas only fluorine was tolera
Autor:
Nicholas Maughan Clayton, Gerard Martin Paul Giblin, Mark Patrick Healy, Anton D. Michel, Riccardo Novelli, Beverley Hammond, Stephen John Atkinson, Sac P. Tang, Susan H. Brown, Matthew R. Johnson, Anita Chowdhury, Alan Naylor, David J. Spalding, Adrian Hall, Iain P. Chessell, Robert Gleave, Tanya Coleman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3657-3662
The preliminary SAR of a series of novel 1,5-biaryl pyrrole EP1 receptor antagonists derived from compound 1 is described. Replacement of the benzyl group of 1 with isosteric groups was investigated. The most effective replacement was found to be the
Autor:
P. Softley, Kenton L. Morgan, D. Rh. Thomas, Tanya Coleman, Hüller Thomas, P. Morgan-Capner, Roland L. Salmon, S. M. Kench, E.O. Caul, Glyn Lewis, S. Stagg, B. Crook, M. Sillist, Rachel M. Chalmers, D. Meadows
Publikováno v:
QJM. 98:247-254
BACKGROUND: Borna disease is an infectious neurological disease of horses, sheep and possibly other animals. A role for Borna disease virus (BDV) in human neurological and psychiatric illness has been proposed, but this hypothesis remains controversi