Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Tanya A. Baldwin"'
Autor:
Kelly M. Grimes, Vikram Prasad, Jiuzhou Huo, Yasuhide Kuwabara, Davy Vanhoutte, Tanya A. Baldwin, Stephanie L. K. Bowers, Anne Katrine Z. Johansen, Michelle A. Sargent, Suh-Chin J. Lin, Jeffery D. Molkentin
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: The ribosomal protein L3-like (RPL3L) is a heart and skeletal muscle-specific ribosomal protein and paralogue of the more ubiquitously expressed RPL3 protein. Mutations in the human RPL3L gene are linked to childhood cardiomyopathy and
Externí odkaz:
https://doaj.org/article/e9e91a84e9de42468035dd74dbc281e1
Autor:
Davy Vanhoutte, Tobias G. Schips, Alexander Vo, Kelly M. Grimes, Tanya A. Baldwin, Matthew J. Brody, Federica Accornero, Michelle A. Sargent, Jeffery D. Molkentin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Beneficial and detrimental effects have been ascribed to the different Thrombospondin (Thbs) proteins in the adult mammalian heart. Here, the authors show that Thbs1-mediated activation of PERK-eIF2α-ATF4-induced autophagy regulates adult cardiomyoc
Externí odkaz:
https://doaj.org/article/391d00d31af043e1bbe47abd09087451
Autor:
Yong Li, Tanya A. Baldwin, Yan Wang, Janani Subramaniam, Anibal Garza Carbajal, Cameron S. Brand, Shane R. Cunha, Carmen W. Dessauer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Adenylyl cyclase type 9 (AC9) is found tightly associated with the scaffolding protein Yotiao and the IKs ion channel in heart. But apart from potential IKs regulation, physiological roles for AC9 are unknown. We show that loss of AC9 in mic
Externí odkaz:
https://doaj.org/article/af877f9b937d4ba8b7fad80085ffdd9a
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The adult human kidney contains over one million nephrons, with each nephron consisting of a tube containing segments that have specialized functions in nutrient and water absorption and waste excretion. The embryonic kidney of Xenopus laevis consist
Externí odkaz:
https://doaj.org/article/9ba1af02573848efb35a89b0e0246632
Publikováno v:
Cells, Vol 8, Iss 9, p 981 (2019)
The subunits KCNQ1 and KCNE1 generate the slowly activating, delayed rectifier potassium current, IKs, that responds to sympathetic stimulation and is critical for human cardiac repolarization. The A-kinase anchoring protein Yotiao facilitates macrom
Externí odkaz:
https://doaj.org/article/f24e0ce6583e4d15882951c9d64deaf3
Autor:
Tanya A. Baldwin, Carmen W. Dessauer
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 5, Iss 1, p 2 (2018)
Cyclic adenosine monophosphate (cAMP), synthesized by adenylyl cyclase (AC), is a universal second messenger that regulates various aspects of cardiac physiology from contraction rate to the initiation of cardioprotective stress response pathways. Lo
Externí odkaz:
https://doaj.org/article/c3f0a3591ebf4d53801965ad9243e4ea
Autor:
André M Lazar, Roshanak Irannejad, Tanya A Baldwin, Aparna B Sundaram, J Silvio Gutkind, Asuka Inoue, Carmen W Dessauer, Mark Von Zastrow
Publikováno v:
eLife, Vol 9 (2020)
GPCRs are increasingly recognized to initiate signaling via heterotrimeric G proteins as they move through the endocytic network, but little is known about how relevant G protein effectors are localized. Here we report selective trafficking of adenyl
Externí odkaz:
https://doaj.org/article/4d7c9f9d3af14e4c9aee9720ecac8b51
Autor:
Tanya A Baldwin, Yong Li, Autumn N Marsden, Susanne Rinné, Anibal Garza‐Carbajal, Roland F R Schindler, Musi Zhang, Mia A Garcia, Venugopal Reddy Venna, Niels Decher, Thomas Brand, Carmen W Dessauer
The establishment of macromolecular complexes by scaffolding proteins is key to the local production of cAMP by anchored adenylyl cyclase (AC) and the subsequent cAMP signaling necessary for cardiac functions. We identify a novel AC scaffold, the Pop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d8324497d49b05f8abf24c02980188
http://hdl.handle.net/10044/1/100293
http://hdl.handle.net/10044/1/100293
Autor:
Tanya A. Baldwin, Yong Li, Autumn Marsden, Roland F.R. Schindler, Musi Zhang, Anibal Garza Carbajal, Mia A. Garcia, Venugopal Reddy Venna, Thomas Brand, Carmen W. Dessauer
The establishment of macromolecular complexes by scaffolding proteins such as A-kinase anchoring proteins is key to the local production of cAMP by anchored adenylyl cyclase (AC) and the subsequent cAMP signaling necessary for many cardiac functions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ddc003f91f0d43b87b26b5f78ad453e
https://doi.org/10.1101/2021.12.21.473719
https://doi.org/10.1101/2021.12.21.473719
Publikováno v:
Molecular Pharmacology. 95:349-360
Membrane-bound adenylyl cyclase (AC) isoforms have distinct regulatory mechanisms that contribute to their signaling specificity and physiologic roles. Although insight into the physiologic relevance of AC9 has progressed, the understanding of AC9 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc258db2a766e3b6199df6fe66138642
https://doi.org/10.1124/mol.118.114595
https://doi.org/10.1124/mol.118.114595