Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Tanya Paquet"'
Autor:
Theresa L. Coetzer, Lizette L. Koekemoer, Elizabeth A. Winzeler, Gregory S. Basarab, Richard T. Eastman, Jean Dam, Gurminder Kaur, André Horatscheck, Sonja B Lauterbach, Sabine Ottilie, Hui Guo, Michael J. Delves, Luisa Nardini, Jacek W. Zawada, Dennis A. Smith, James Duffy, Leslie J. Street, Tanya Paquet, Belinda C. Bezuidenhout, Claire Le Manach, Lyn-Marie Birkholtz, Dorjbal Dorjsuren, Liezl Gibhard, Dalu Mancama, Anton Simeonov, David A. Fidock, Christel Brunschwig, Sachel Mok, Daniel C. Talley, Nelius Venter, Mariëtte van der Watt, Grant A. Boyle, John G Woodland, Sergio Wittlin, Ayesha Aswat, Janette Reader, Nina Lawrence, Dale Taylor, Mathew Njoroge, Kelly Chibale, Tomas Yeo, Anjo Theron, Lutete Peguy Khonde, Erica Erlank, Thomas W. von Geldern, Kathryn J. Wicht
Publikováno v:
Journal of Medicinal Chemistry. 64:2291-2309
A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold p
Autor:
Erick Strauss, Leanne Barnard, Kevin J. Saliba, Willem A. L. van Otterlo, Anton R. Hamann, Konrad J Mostert, Riyad Domingo, Erick T. Tjhin, Tanya Paquet, Renier van der Westhuyzen
Publikováno v:
Medchemcomm
The biosynthesis of the essential metabolic cofactor coenzyme A (CoA) has been receiving increasing attention as a new target that shows potential to counter the rising resistance to established antimicrobials. In particular, phosphopantothenoylcyste
Autor:
Claire, Le Manach, Jean, Dam, John G, Woodland, Gurminder, Kaur, Lutete P, Khonde, Christel, Brunschwig, Mathew, Njoroge, Kathryn J, Wicht, André, Horatscheck, Tanya, Paquet, Grant A, Boyle, Liezl, Gibhard, Dale, Taylor, Nina, Lawrence, Tomas, Yeo, Sachel, Mok, Richard T, Eastman, Dorjbal, Dorjsuren, Daniel C, Talley, Hui, Guo, Anton, Simeonov, Janette, Reader, Mariëtte, van der Watt, Erica, Erlank, Nelius, Venter, Jacek W, Zawada, Ayesha, Aswat, Luisa, Nardini, Theresa L, Coetzer, Sonja B, Lauterbach, Belinda C, Bezuidenhout, Anjo, Theron, Dalu, Mancama, Lizette L, Koekemoer, Lyn-Marie, Birkholtz, Sergio, Wittlin, Michael, Delves, Sabine, Ottilie, Elizabeth A, Winzeler, Thomas W, von Geldern, Dennis, Smith, David A, Fidock, Leslie J, Street, Gregory S, Basarab, James, Duffy, Kelly, Chibale
Publikováno v:
Journal of medicinal chemistry. 64(4)
A novel diazaspiro[3.4]octane series was identified from a
Autor:
Jean Dam, Keletso Maepa, Lutete Peguy Khonde, Claire Le Manach, Janette Reader, Mariëtte van der Watt, Gregory S. Basarab, Sergio Wittlin, John Okombo, Kathryn J. Wicht, James Duffy, Aloysius T. Nchinda, Dale Taylor, André Horatscheck, Mathew Njoroge, Christel Brunschwig, Timothy J. Egan, Nina Lawrence, Ana Carolina C. de Sousa, Leslie J. Street, Kelly Chibale, Lyn-Marie Birkholtz, Ana Andrijevic, Liezl Gibhard, Tanya Paquet, Kailash P. Pawar, Paul V. Fish
Publikováno v:
J Med Chem
A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0f65b29b16b46e7c416d1fc66f6377
https://europepmc.org/articles/PMC7756195/
https://europepmc.org/articles/PMC7756195/
Autor:
Claire Le Manach, Dale Taylor, Diego Gonzàlez Cabrera, James Duffy, Nina Lawrence, Santiago Ferrer, Kelly Chibale, Mathew Njoroge, Christel Brunschwig, Efrem Abay, Iñigo Angulo-Barturen, María-Belén Jiménez-Díaz, María Santos Martínez, Jeremy N. Burrows, Sergio Wittlin, Kathryn J. Wicht, Aloysius T. Nchinda, Tanya Paquet, Maria Jose Lafuente-Monasterio, Leslie J. Street
Publikováno v:
Journal of Medicinal Chemistry. 61:4213-4227
Optimization of a chemical series originating from whole-cell phenotypic screening against the human malaria parasite, Plasmodium falciparum, led to the identification of two promising 2,6-disubstituted imidazopyridine compounds, 43 and 74. These com
Autor:
Christel Brunschwig, Tanya Paquet, Efrem Abay, Mathew Njoroge, Liezl Gibhard, Lubbe Wiesner, Leslie J. Street, Dale Taylor, Kelly Chibale, Sergio Wittlin, Nina Lawrence, Gregory S. Basarab
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
The; in vivo; antimalarial efficacies of two phosphatidylinositol 4-kinase (PI4K) inhibitors, a 3,5-diaryl-2-aminopyrazine sulfoxide and its corresponding sulfone metabolite, were evaluated in the NOD-scid IL2Rγ; null; (NSG) murine malaria disease m
Autor:
Tanya Paquet, David A. Fidock, Efrem Abay, Iñigo Angulo-Barturen, Kigbafori D. Silué, Diego Gonzàlez Cabrera, Mathew Njoroge, Leslie J. Street, Rintis Noviyanti, Karen L. White, Grennady Wirjanata, Cristina Donini, Michael J Witty, Nina Lawrence, Dalu Mancama, Lyn-Marie Birkholtz, Claire Le Manach, Sergio Wittlin, Ric N. Price, María Belén Jiménez-Díaz, Lubbe Wiesner, Jutta Marfurt, Didier Leroy, David Waterson, Peter Siegl, Christel Brunschwig, Paul V. Fish, Aloysius T. Nchinda, Manu Vanaerschot, Jacob A. McPhail, Mariëtte van der Watt, Dale Taylor, Susan A. Charman, Gregory S. Basarab, Carmen de Kock, Esperanza Herreros, John E. Burke, Suresh Solapure, Kennan C. Marsh, Francisco-Javier Gamo, Kelly Chibale, Theresa L. Coetzer, James Duffy, Rosemary Rochford, Janette Reader, Paolo Denti, Dennis A. Smith, Benjamin Blasco
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
Autor:
André Horatscheck, Ana Andrijevic, Aloysius T. Nchinda, Claire Le Manach, Tanya Paquet, Lutete Peguy Khonde, Jean Dam, Kailash Pawar, Dale Taylor, Nina Lawrence, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge, Janette Reader, Mariëtte van der Watt, Kathryn Wicht, Ana Carolina C. de Sousa, John Okombo, Keletso Maepa, Timothy J. Egan, Lyn-Marie Birkholtz, Gregory S. Basarab, Sergio Wittlin, Paul V. Fish, Leslie J. Street, James Duffy, Kelly Chibale
Publikováno v:
Journal of Medicinal Chemistry. 64:1762-1762
Autor:
Janette Reader, Claire Le Manach, María Santos Martínez, Leslie J. Street, Mariette Botha, Iñigo Angulo-Barturen, Diego Gonzàlez Cabrera, Dale Taylor, David Waterson, Michael J Witty, María-Belén Jiménez-Díaz, Theresa L. Coetzer, Kelly Chibale, Christel Brunschwig, Rajkumar Dhinakaran, Sergio Wittlin, Tanya Paquet, Alisje Churchyard, Ze Han, Elizabeth A. Winzeler, Sridevi Bashyam, Sonja B Lauterbach, Mathew Njoroge, Stephan Meister, Lyn-Marie Birkholtz, Santiago Ferrer
Publikováno v:
Journal of Medicinal Chemistry. 58:8713-8722
Toward improving pharmacokinetics, in vivo efficacy, and selectivity over hERG, structure-activity relationship studies around the central core of antimalarial imidazopyridazines were conducted. This study led to the identification of potent pyrazolo
Autor:
Christel Brunschwig, Sergio Wittlin, Claire Le Manach, Mathew Njoroge, Paul V. Fish, Aloysius T. Nchinda, Dale Taylor, Liezl Gibhard, Nina Lawrence, Kelly Chibale, Kathryn J. Wicht, James Duffy, Charles J. Eyermann, Tanya Paquet, Gregory S. Basarab, Leslie J. Street
Publikováno v:
Journal of medicinal chemistry. 61(20)
A lead-optimization program around a 2,6-imidazopyridine scaffold was initiated based on the two early lead compounds, 1 and 2, that were shown to be efficacious in an in vivo humanized Plasmodium falciparum NODscidIL2Rγnull mouse malaria infection