Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Tanya, Puhalovich"'
Autor:
Stanley C. Xie, Yinuo Wang, Craig J. Morton, Riley D. Metcalfe, Con Dogovski, Charisse Flerida A. Pasaje, Elyse Dunn, Madeline R. Luth, Krittikorn Kumpornsin, Eva S. Istvan, Joon Sung Park, Kate J. Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N. Bhebhe, Dana M. Klug, Peter J. Rutledge, Luiz C. Godoy, Sumanta Dey, Mariana Laureano De Souza, Jair L. Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerry Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas Williamson, Gouranga P. Jana, Bikash C. Maity, Patrick Thomson, Thomas Foley, Derek S. Tan, Jacquin C. Niles, Byung Woo Han, Daniel E. Goldberg, Jeremy Burrows, David A. Fidock, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael D. W. Griffin, Matthew H. Todd, Leann Tilley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a ne
Externí odkaz:
https://doaj.org/article/74ceb3d2587846d1a75544faccf7d8f1
Autor:
Stanley C. Xie, Riley D. Metcalfe, Elyse Dunn, Craig J. Morton, Shih-Chung Huang, Tanya Puhalovich, Yawei Du, Sergio Wittlin, Shuai Nie, Madeline R. Luth, Liting Ma, Mi-Sook Kim, Charisse Flerida A. Pasaje, Krittikorn Kumpornsin, Carlo Giannangelo, Fiona J. Houghton, Alisje Churchyard, Mufuliat T. Famodimu, Daniel C. Barry, David L. Gillett, Sumanta Dey, Clara C. Kosasih, William Newman, Jacquin C. Niles, Marcus C. S. Lee, Jake Baum, Sabine Ottilie, Elizabeth A. Winzeler, Darren J. Creek, Nicholas Williamson, Michael W. Parker, Stephen Brand, Steven P. Langston, Lawrence R. Dick, Michael D.W. Griffin, Alexandra E. Gould, Leann Tilley
Publikováno v:
Science. 376:1074-1079
Aminoacyl transfer RNA (tRNA) synthetases (aaRSs) are attractive drug targets, and we present class I and II aaRSs as previously unrecognized targets for adenosine 5′-monophosphate–mimicking nucleoside sulfamates. The target enzyme catalyzes the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33885bcc50dbddf18b27ef08501fecec
https://doi.org/10.1126/science.abn0611
https://doi.org/10.1126/science.abn0611
Autor:
Stanley C, Xie, Riley D, Metcalfe, Hirotake, Mizutani, Tanya, Puhalovich, Eric, Hanssen, Craig J, Morton, Yawei, Du, Con, Dogovski, Shih-Chung, Huang, Jeffrey, Ciavarri, Paul, Hales, Robert J, Griffin, Lawrence H, Cohen, Bei-Ching, Chuang, Sergio, Wittlin, Ioanna, Deni, Tomas, Yeo, Kurt E, Ward, Daniel C, Barry, Boyin, Liu, David L, Gillett, Benigno F, Crespo-Fernandez, Sabine, Ottilie, Nimisha, Mittal, Alisje, Churchyard, Daniel, Ferguson, Anna Caroline C, Aguiar, Rafael V C, Guido, Jake, Baum, Kirsten K, Hanson, Elizabeth A, Winzeler, Francisco-Javier, Gamo, David A, Fidock, Delphine, Baud, Michael W, Parker, Stephen, Brand, Lawrence R, Dick, Michael D W, Griffin, Alexandra E, Gould, Leann, Tilley
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Here, we describe inhibitors of the Plasmodium proteasome, an enzymatic complex that malaria parasites rely on to degrade proteins. Starting from inhibitors developed to treat cancer, derivatives were designed and synthesized with the ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a17d17dad9983ee3c287198b34e727b8
https://pubmed.ncbi.nlm.nih.gov/34548400
https://pubmed.ncbi.nlm.nih.gov/34548400
Autor:
Benigno F. Crespo-Fernandez, Eric Hanssen, Elizabeth A. Winzeler, Ioanna Deni, Lawrence Cohen, Du Yawei, Daniel C. Barry, Leann Tilley, Riley D. Metcalfe, David L. Gillett, Kurt E. Ward, Bei-Ching Chuang, Hirotake Mizutani, Lawrence R. Dick, Anna Caroline Campos Aguiar, David A. Fidock, Kirsten K. Hanson, Boyin Liu, Alexandra E. Gould, Stanley C. Xie, Rafael Victorio Carvalho Guido, Francisco-Javier Gamo, Tanya Puhalovich, Shih-Chung Huang, Daniel Ferguson, Paul Hales, Con Dogovski, Sabine Ottilie, Nimisha Mittal, Craig J. Morton, Sergio Wittlin, Robert J. Griffin, Delphine Baud, Tomas Yeo, Michael D. W. Griffin, Jake Baum, Stephen Brand, Alisje Churchyard, Jeffrey Ciavarri, Michael W. Parker
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
The Plasmodium falciparum proteasome is a potential antimalarial drug target. We have identified a series of amino-amide boronates that are potent and specific inhibitors of the P. falciparum 20S proteasome (Pf20S) beta5 active site and that exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1732262eee41ce63468baae5797862
