Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Tanuza, Das"'
Autor:
Xi Zhang, Tanuza Das, Tiffany F. Chao, Vickie Trinh, Rogger P. Carmen-Orozco, Jonathan P. Ling, Petr Kalab, Lindsey R. Hayes
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110109- (2024)
Summary: TDP-43 nuclear clearance and cytoplasmic aggregation are hallmarks of TDP-43 proteinopathies. We recently demonstrated that binding to endogenous nuclear GU-rich RNAs sequesters TDP-43 in the nucleus by restricting its passive nuclear export
Externí odkaz:
https://doaj.org/article/4a95f8e106484c80bca2d789dc2e91c2
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract The deubiquitinating enzyme USP15 is implicated in several human cancers by regulating different cellular processes, including splicing regulation. However, the underlying molecular mechanisms of its functional relevance and the successive r
Externí odkaz:
https://doaj.org/article/e8adea205fd342bca4625d9edec4ee87
Autor:
Manivannan Subramanian, Seung Jae Hyeon, Tanuza Das, Yoon Seok Suh, Yun Kyung Kim, Jeong-Soo Lee, Eun Joo Song, Hoon Ryu, Kweon Yu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Hyperphosphorylated Tau accumulation promotes neurodegeneration in Alzheimer’s disease. Here, the authors screen a miRNA library in Drosophila and identify a conserved ubiquitin ligase that directs Tau for autophagic degradation, uncovering a poten
Externí odkaz:
https://doaj.org/article/ee8a7f6a151f4e33bd0f9accda17a866
Autor:
Manivannan Subramanian, Seung Jae Hyeon, Tanuza Das, Yoon Seok Suh, Yun Kyung Kim, Jeong-Soo Lee, Eun Joo Song, Hoon Ryu, Kweon Yu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/20c632fba67048a084decf03accefee3
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4728 (2021)
Ubiquitination and deubiquitination are protein post-translational modification processes that have been recognized as crucial mediators of many complex cellular networks, including maintaining ubiquitin homeostasis, controlling protein stability, an
Externí odkaz:
https://doaj.org/article/6ba81481f5f641398cfb22c130173b71
Autor:
Karim Mersal, Mohammed S. Abdel-Maksoud, Eslam M.H. Ali, Usama M. Ammar, Seyed-Omar Zaraei, Md Mamunul Haque, Tanuza Das, Noha F. Hassan, Eunice EunKyeong Kim, Jun-Seok Lee, HaJeung Park, Kwan Hyi Lee, Mohammed I. El-Gamal, Hee-Kwon Kim, Chang-Hyun Oh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37a89818c3729603d1479bb6c2b1be5a
https://doi.org/10.2139/ssrn.4454234
https://doi.org/10.2139/ssrn.4454234
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 4028 (2020)
Ubiquitination and deubiquitination play a critical role in all aspects of cellular processes, and the enzymes involved are tightly regulated by multiple factors including posttranslational modifications like most other proteins. Dysfunction or misre
Externí odkaz:
https://doaj.org/article/2836a3f616714d2aa118459850ae9b74
Autor:
Eslam M.H. Ali, Karim I. Mersal, Usama M. Ammar, Seyed-Omar Zaraei, Mohammed S. Abdel-Maksoud, Mohammed I. El-Gamal, Md Mamunul Haque, Tanuza Das, Eunice EunKyeong Kim, Jun-Seok Lee, Kwan Hyi Lee, Hee-Kwon Kim, Chang-Hyun Oh
In the current article, we introduce design of a new series of 4-(imidazol-5-yl)pyridines with improved anticancer activity and selective B-RAF /p38α kinase inhibitory activity. Based on a previous work, a group of structural modifications were appl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a638fe57a58f619c85fca202e101c1bc
https://strathprints.strath.ac.uk/79144/1/Ali_etal_EJPS_2022_Structural_optimization_of_4_imidazol_5_yl_pyridine_derivatives.pdf
https://strathprints.strath.ac.uk/79144/1/Ali_etal_EJPS_2022_Structural_optimization_of_4_imidazol_5_yl_pyridine_derivatives.pdf
Autor:
Eslam M H, Ali, Karim I, Mersal, Usama M, Ammar, Seyed-Omar, Zaraei, Mohammed S, Abdel-Maksoud, Mohammed I, El-Gamal, Md Mamunul, Haque, Tanuza, Das, Eunice EunKyeong, Kim, Jun-Seok, Lee, Kwan Hyi, Lee, Hee-Kwon, Kim, Chang-Hyun, Oh
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 171
In the current article, we introduce design of a new series of 4-(imidazol-5-yl)pyridines with improved anticancer activity and selective B-RAF
Autor:
Kweon Yu, Yoon Seok Suh, Yun Kyung Kim, Eun Joo Song, Jeong-Soo Lee, Manivannan Subramanian, Hoon Ryu, Seung Jae Hyeon, Tanuza Das
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
The formation of hyperphosphorylated intracellular Tau tangles in the brain is a hallmark of Alzheimer's disease (AD). Tau hyperphosphorylation destabilizes microtubules, promoting neurodegeneration in AD patients. To identify suppressors of tau-medi