Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tanushree Phadke"'
Autor:
Anne Bothmer, Tanushree Phadke, Luis A. Barrera, Carrie M Margulies, Christina S. Lee, Frank Buquicchio, Sean Moss, Hayat S. Abdulkerim, William Selleck, Hariharan Jayaram, Vic E. Myer, Cecilia Cotta-Ramusino
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
CRISPR-Cas9 has rapidly become a common molecular biology tool for modifying genomes and has been modified to generate single-strand nicks as well as double-strand breaks. Here the authors explore the DNA repair pathways activated by the different va
Externí odkaz:
https://doaj.org/article/0e7ab32becea4c83bb655f0d5113f731
Autor:
Ewa Surdziel, Ieuan Clay, Florian Nigsch, Anke Thiemeyer, Cyril Allard, Gregory Hoffman, John S Reece-Hoyes, Tanushree Phadke, Romain Gambert, Caroline Gubser Keller, Marie-Gabrielle Ludwig, Birgit Baumgarten, Mathias Frederiksen, Dirk Schübeler, Klaus Seuwen, Tewis Bouwmeester, Barna D Fodor
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183679 (2017)
Macrophages are key cell types of the innate immune system regulating host defense, inflammation, tissue homeostasis and cancer. Within this functional spectrum diverse and often opposing phenotypes are displayed which are dictated by environmental c
Externí odkaz:
https://doaj.org/article/ee373e8c093841f49ffecddc87bb7dda
Autor:
Luis A. Barrera, Hayat S Abdulkerim, Frank Buquicchio, Hariharan Jayaram, Carrie M Margulies, Tanushree Phadke, Christina S. Lee, Anne Bothmer, William Selleck, Sean Moss, Vic E. Myer, Cecilia Cotta-Ramusino
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications
The CRISPR–Cas9 system provides a versatile toolkit for genome engineering that can introduce various DNA lesions at specific genomic locations. However, a better understanding of the nature of these lesions and the repair pathways engaged is criti
Autor:
Tanushree Phadke, Marie-Gabrielle Ludwig, Barna D. Fodor, Florian Nigsch, John S. Reece-Hoyes, Anke Thiemeyer, Ieuan Clay, Caroline Gubser Keller, Birgit Baumgarten, Dirk Schübeler, Cyril Allard, Gregory R. Hoffman, Tewis Bouwmeester, Mathias Frederiksen, Romain Gambert, Ewa Surdziel, Klaus Seuwen
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183679 (2017)
PLoS ONE
PLoS ONE
Macrophages are key cell types of the innate immune system regulating host defense, inflammation, tissue homeostasis and cancer. Within this functional spectrum diverse and often opposing phenotypes are displayed which are dictated by environmental c
Autor:
Craig Mickanin, Linda Bagdasarian, Gregory R. Hoffman, Jeffery A. Porter, Kay Xiang, Huili Zhai, Zainab Jagani, Matthew J. Meyer, Frank Buxton, Vic E. Myer, Nadire Ramadan, Rami Rahal, Elizabeth Frias, Charles W. M. Roberts, Janina Huber, Frank Stegmeier, Kristy Haas, Gregory McAllister, Tanushree Phadke, Mariela Jaskelioff, Rodrigo Romero, Veronica Saenz-Vash, Alicia Lindeman, Dongshu Chen, Boris G. Wilson, Margaret E. McLaughlin, Nicholas Keen
Publikováno v:
Proceedings of the National Academy of Sciences. 111:3128-3133
Defects in epigenetic regulation play a fundamental role in the development of cancer, and epigenetic regulators have recently emerged as promising therapeutic candidates. We therefore set out to systematically interrogate epigenetic cancer dependenc
Publikováno v:
Molecular Therapy. 23
Sickle Cell Anemia is a recessive disorder caused by a single point mutation in the human beta globin (HBB) gene. Affecting nearly 1 million people worldwide, this disease is severely lacking in long-term treatment options and is a prime candidate fo
Autor:
Christine Stephan, William R. Sellers, Deborah Castelletti, Jeffery A. Porter, Julie L. Bernard, Sandra Mollé, Mark Stump, Tami Hood, Joshua M. Korn, Audrey Kauffmann, Giorgio G. Galli, Kristine Yu, Li Li, Marc Hattenberger, Javad Golji, Zainab Jagani, Marco Wallroth, Tobias Schmelzle, Philippe Megel, Raymond Pagliarini, Rosemary Barrett, Yingzi Yue, Richard S. Eldridge, Jan Weiler, Alberto C. Vitari, Konstantinos J. Mavrakis, Kalyani Gampa, Elizabeth Ackley, Rosalie deBeaumont, Qiong Shen, Joel Berger, Tanja Schouwey, Franklin Chung, E. Robert McDonald, Gregory McAllister, Christelle Stamm, Frances Shanahan, Aurore Desplat, Iris Kao, Thomas A. Perkins, Antoine de Weck, Kavitha Venkatesan, Albert Lai, Jennifer Johnson, Roland Widmer, David A. Ruddy, Avnish Kapoor, Brian Repko, François Gauter, Nicholas Keen, Tanushree Phadke, Eric Billy, Sosathya Sovath, Typhaine Martin, Elizabeth Frias, Justina X. Caushi, Vic E. Myer, Malini Varadarajan, William C. Forrester, Fei Feng, Hans Bitter, Ralph Tiedt, Yue Liu, Jing Zhang, Dorothee Abramowski, Dhiren Belur, Volker M. Stucke, Odile Weber, Mathias Jenal, Ali Farsidjani, Jianjun Yu, Rebecca Billig, JiaJia Feng, A. B. Meyer, Kristen Hurov, Veronica Gibaja, Michael D. Jones, Daisy Flemming, Donald A. Dwoske, Jilin Liu, Clara Delaunay, William Duong, Frank Buxton, Kaitlin J. Macchi, Saskia M. Brachmann, Alice T. Loo, Craig Mickanin, Francesco Hofmann, Frank Stegmeier, Kristy Haas, Gregory R. Hoffman, Marta Cortes-Cros, Roger Caothien, Shumei Liu, Serena J. Silver, Michael R. Schlabach, Emma Lees, Nadire Ramadan, Qiumei Liu, Zhenhai Gao
Publikováno v:
Cell. 170:577-592.e10
Elucidation of the mutational landscape of human cancer has progressed rapidly and been accompanied by the development of therapeutics targeting mutant oncogenes. However, a comprehensive mapping of cancer dependencies has lagged behind and the disco
Autor:
Hari Jayaram, Hayat S Abdulkerim, Luis A. Barrera, Tanushree Phadke, Christina Lee, S. Moss, Anne Bothmer, Cecilia Cotta-Ramusino
Publikováno v:
Molecular Therapy. 24:S230
Sickle Cell Anemia is an inherited recessive disorder caused by a single point mutation in the human beta globin (HBB) gene resulting in an abnormal type of hemoglobin. Here we report targeting the HBB locus using CRISPR/Cas9 technology for correctio
Autor:
Margaret E. McLaughlin, Tanushree Phadke, Charles W. M. Roberts, Boris G. Wilson, Kay Xiang, Linda Bagdasarian, Rami Rahal, Janina Huber, Zainab Jagani, Nicholas Keen, Craig Mickanin, Matthew J. Meyer, Rodrigo Romero, Frank Stegmeier, Nadire Ramadan, Gregory R. Hoffman, Gregory McAllister, Elizabeth Frias, Mariela Jaskelioff, Vic E. Myer, Jeffrey A. Porter, Dongshu Chen, Frank Buxton, Alicia Lindeman, Kristy Haas
Publikováno v:
Molecular Cancer Therapeutics. 12:PR06-PR06
Epigenetic dysregulation is an emerging hallmark of cancers, and the identification of recurrent somatic mutations in chromatin regulators implies a causal role for altered chromatin states in tumorigenesis. As the majority of epigenetic mutations ar