Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tanuja Koppal"'
Publikováno v:
Brain Research. 867:115-121
15-deoxy-Delta(12,14)-PGJ(2), a cyclopentenone derivative of PGD(2), was recently reported [Petrova et al., Proc. Natl. Acad. Sci. USA 96 (1999) 4668-4673] to suppress inducible nitric oxide synthase (iNOS) production in microglia and mixed glial cul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acba53334dc95add6ffb1fb7b45b3934
https://doi.org/10.1016/s0006-8993(00)02270-8
https://doi.org/10.1016/s0006-8993(00)02270-8
Autor:
Tanuja Koppal, Thomas J. Lukas, Tatiana V. Petrova, D. Martin Watterson, Linda J. Van Eldik, Salida Mirzoeva
Publikováno v:
Brain Research. 844:126-134
A high-throughput screening (HTS) assay for inhibitors of nitric oxide (NO) production by activated microglia was developed and used to compare the relative activities of various anti-inflammatory compounds and cell-permeable protein kinase inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b99d5993a2e374a086adf9e4b5d8694
https://doi.org/10.1016/s0006-8993(99)01911-3
https://doi.org/10.1016/s0006-8993(99)01911-3
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1453:407-411
Peroxynitrite, formed by the reaction between nitric oxide and superoxide, leads to the oxidation of proteins, lipids, and DNA, and nitrates thiols such as cysteine and glutathione, and amino acids like tyrosine. Previous in vitro studies have shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d152a5bb6d6f532f1efff6b84daeec8
https://doi.org/10.1016/s0925-4439(99)00014-9
https://doi.org/10.1016/s0925-4439(99)00014-9
Autor:
Jennifer Drake, Tanuja Koppal, David Allan Butterfield, Sridhar Varadarajan, L Bettenhausen, Servet Yatin, B Jordan
Publikováno v:
Journal of Neurochemistry. 72:310-317
Peroxynitrite (ONOO ) is a highly reactive, oxidizing anion with a half-life of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e6c84456d1876651a9fa0cdd86914f
https://doi.org/10.1046/j.1471-4159.1999.0720310.x
https://doi.org/10.1046/j.1471-4159.1999.0720310.x
Publikováno v:
Analytical Letters. 32:1183-1192
Peroxynitrite-induced oxidative stress was investigated in red blood cells by luminol-dependent chemiluminescence. Red blood cells are susceptible to free radical damage due to the abundance of oxygen, presence of iron and other agents such as polyun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71525ed1cf7dae865edb089284fba690
https://doi.org/10.1080/00032719908542887
https://doi.org/10.1080/00032719908542887
Autor:
Ram Subramaniam, K. Hensley, Nathan Hall, Servet Yatin, Beverly J. Howard, Kerry L. Allen, John M. Carney, Michael Y. Aksenov, D. Allan Butterfield, Tanuja Koppal, Marina V. Aksenova
Publikováno v:
Annals of the New York Academy of Sciences. 854:448-462
The free radical theory of aging proposes that reactive oxygen species (ROS) cause oxidative damage over the lifetime of the subject. It is the cumulative and potentially increasing amount of accumulated damage that accounts for the dysfunctions and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0d543e98311305a13fafc4b2df1a43
https://doi.org/10.1111/j.1749-6632.1998.tb09924.x
https://doi.org/10.1111/j.1749-6632.1998.tb09924.x
Autor:
M. Renuka Prasad, Tanuja Koppal, Jennifer Drake, D. Allan Butterfield, H.S. Dhillon, Ram Subramaniam
Publikováno v:
Brain Research. 786:270-273
magnetic resonance EPR spin trapping and spin labeling, measuring A b-induced protein and lipid oxidation, and investigating effects of A b on oxidation of and dysfunc- tions in proteins of brain membranes and neuronal cultures wx and their preventio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f28b71a9e405fd6085379f33c7d1956
https://doi.org/10.1016/s0006-8993(97)01466-2
https://doi.org/10.1016/s0006-8993(97)01466-2
Autor:
Ram Subramaniam, Servet Yatin, Tanuja Koppal, B Jordan, David Allan Butterfield, Jennifer Drake, M Green
Publikováno v:
Neurochemical Research. 23:1403-1410
Amyloid beta-peptide (Abeta) is a key factor in the neurotoxicity of Alzheimer's disease (AD). Recent research has shown that Abeta-mediated neurotoxicity involves free radicals and that Abeta peptides can initiate multiple membrane alterations, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2dfdc14c7f1f022a46f3edc7c90e984
https://doi.org/10.1023/a:1020754807671
https://doi.org/10.1023/a:1020754807671
Publikováno v:
Scopus-Elsevier
Summary: The drug discovery and the drug development processes represent a continuum of recursive activities that range from initial drug target identification to final Food and Drug Administration approval and marketing of a new therapeutic. Drug di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9321fae6ac268d28cd682cf76f0f894
https://pubmed.ncbi.nlm.nih.gov/12070358
https://pubmed.ncbi.nlm.nih.gov/12070358
Autor:
Linda J. Van Eldik, Jeffrey M. Craft, James P. Schavocky, D. Martin Watterson, Ling Guo, Tanuja Koppal, Amy G.M Lam, Keith T. Akama, Barat Samy
Publikováno v:
Neurobiology of aging. 22(5)
Compelling evidence links chronic activation of glia and the subsequent cycle of neuroinflammation and neuronal dysfunction to the progression of neurodegeneration in disorders such as Alzheimer's disease (AD). S100B, a glial-derived cytokine, is sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa385c78fd67430ac080fb30ee20786
https://pubmed.ncbi.nlm.nih.gov/11705636
https://pubmed.ncbi.nlm.nih.gov/11705636