Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tanu Parmar"'
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103150- (2024)
Summary: During aging and in retinal degenerative diseases, vulnerable retinal pigment epithelial (RPE) cells are subject to mitochondrial dysfunction, creating a need for accessibility to tools which can facilitate assessment of the ocular posterior
Externí odkaz:
https://doaj.org/article/f61feaede64c4babacb3ddd32fbbd7a8
Publikováno v:
Stem Cell Research, Vol 27, Iss , Pp 95-104 (2018)
Accumulation of lipofuscin in the retinal pigmented epithelium (RPE) is observed in retinal degenerative diseases including Stargardt disease and age-related macular degeneration. Bis-retinoid N-retinyl-N-retinylidene ethanolamine (A2E) is a major co
Externí odkaz:
https://doaj.org/article/fb520ff66a75468e9d74fa07c175268f
Publikováno v:
The FASEB Journal. 36
Publikováno v:
Pharmacological Research. 188:106675
Publikováno v:
Mol Pharmacol
Degeneration of photoreceptors caused by excessive illumination, inherited mutations, or aging is the principal pathology of blinding diseases. Pharmacological compounds that stabilize the visual receptor rhodopsin and modulate the cellular pathways
Autor:
Joseph Thomas Ortega, Tanu Parmar, Miguel Carmena‐Bargueño, Horacio Pérez‐Sánchez, Beata Jastrzebska
Publikováno v:
J Neurosci Res
The balanced homeostasis of the G protein–coupled receptor (GPCR), rhodopsin (Rho), is required for vision. Misfolding mutations in Rho cause photoreceptor death, leading to retinitis pigmentosa (RP) and consequently blindness. With no cure current
Publikováno v:
Exp Biol Med (Maywood)
Progressive retinal degeneration manifesting as age-related macular degeneration (AMD) in the elderly affects millions of individuals worldwide. Among various blinding diseases, AMD is the leading cause of central vision impairment in developed count
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d683b051e2f03951ec4b5d4e06ed9f23
https://europepmc.org/articles/PMC7787542/
https://europepmc.org/articles/PMC7787542/
Autor:
Songqi Gao, Krzysztof Palczewski, Tanu Parmar, Marcin Golczak, Grazyna Palczewska, Beata Jastrzebska, Zhiqian Dong
Publikováno v:
Molecular Pharmacology. 94:1132-1144
Continuous regeneration of the 11-cis-retinal visual chromophore from all-trans-retinal is critical for vision. Insufficiency of 11-cis-retinal arising from the dysfunction of key proteins involved in its regeneration can impair retinal health, ultim
Publikováno v:
J Biol Chem
Rhodopsin (Rho) is a visual G protein–coupled receptor expressed in the rod photoreceptors of the eye, where it mediates transmission of a light signal into a cell and converts this signal into a nerve impulse. More than 100 mutations in Rho are li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4f5896d9d6e5cacb4493aae4f8a6f7
https://europepmc.org/articles/PMC6527159/
https://europepmc.org/articles/PMC6527159/
Autor:
Vipul M. Parmar, Masayo Takahashi, John W. Crabb, Tanu Parmar, Akiko Maeda, Lindsay Perusek, Anouk Georges
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(9)
It has become increasingly important to understand how retinal inflammation is regulated because inflammation plays a role in retinal degenerative diseases. Lipocalin 2 (LCN2), an acute stress response protein with multiple innate immune functions, i