Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Tannin A, Schmidt"'
Autor:
Du Wenqiang, Ashkan Novin, Yamin Liu, Junaid Afzal, Yasir Suhail, Shaofei Liu, Nicole R. Gavin, Jennifer R. Jorgensen, Christopher M. Morosky, Reinaldo Figueroa, Tannin A. Schmidt, Melinda Sanders, Molly A. Brewer, Kshitiz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Scar tissue formation is a hallmark of wound repair in adults and can chronically affect tissue architecture and function. To understand the general phenomena, we sought to explore scar-driven imbalance in tissue homeostasis caused by a comm
Externí odkaz:
https://doaj.org/article/6a3069e8432b445ebee9af42f33137d5
Autor:
Nabangshu Das, Luiz G. N. de Almeida, Afshin Derakhshani, Daniel Young, Kobra Mehdinejadiani, Paul Salo, Alexander Rezansoff, Gregory D. Jay, Christian P. Sommerhoff, Tannin A. Schmidt, Roman Krawetz, Antoine Dufour
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Altered expression and function of the extracellular matrix protein PRG4 have been associated with osteoarthritis. Here, the authors show that mast cell tryptase β cleaves PRG4, resulting in a reduction of lubrication and activation of inflammation
Externí odkaz:
https://doaj.org/article/acd1e0dd071f4882af74316106133957
Autor:
Roman J. Krawetz, Saleem Abubacker, Catherine Leonard, Anand O. Masson, Sophia Shah, Nadia Narendran, Pankaj Tailor, Suresh C. Regmi, Elodie Labit, Nicoletta Ninkovic, Jessica May Corpuz, Kenichi Ito, T. Michael Underhill, Paul T. Salo, Tannin A. Schmidt, Jeff A. Biernaskie
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-18 (2022)
Abstract The wound healing response is one of most primitive and conserved physiological responses in the animal kingdom, as restoring tissue integrity/homeostasis can be the difference between life and death. Wound healing in mammals is mediated by
Externí odkaz:
https://doaj.org/article/6cfd5dea43f0478bbcc1d17da0a3891f
Autor:
Kristo Nuutila, Mohamadmahdi Samandari, Yori Endo, Yuteng Zhang, Jacob Quint, Tannin A. Schmidt, Ali Tamayol, Indranil Sinha
Publikováno v:
Bioactive Materials, Vol 8, Iss , Pp 296-308 (2022)
Acute and chronic wounds affect millions of people around the world, imposing a growing financial burden on patients and hospitals. Despite the application of current wound management strategies, the physiological healing process is disrupted in many
Externí odkaz:
https://doaj.org/article/32779d4bf58149daa66fc087c6a8e1f1
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0291649 (2023)
Bone disease is highly prevalent in patients with chronic kidney disease (CKD), leading to an increased risk of bone fractures. This is due in part to metabolic acid-induced bone dissolution. Bisphosphonates (BPPs) are a potential treatment for inhib
Externí odkaz:
https://doaj.org/article/7f453ff2139445ee860acf6fe013d548
Autor:
Yun Jin Ashley Sin, Rebecca MacLeod, Adam P. Tanguay, Andrew Wang, Olivia Braender-Carr, Teraesa M. Vitelli, Gregory D. Jay, Tannin A. Schmidt, Mary K. Cowman
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The size, conformation, and organization of the glycosaminoglycan hyaluronan (HA) affect its interactions with soluble and cell surface-bound proteins. HA that is induced to form stable networks has unique biological properties relative to unmodified
Externí odkaz:
https://doaj.org/article/3f4e77d45968469ea3503c7bc629f2b0
Autor:
Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Tannin A. Schmidt, Jennifer Totonchy, Khaled A. Elsaid
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-16 (2021)
Abstract Background Synovial macrophages perform a multitude of functions that include clearance of cell debris and foreign bodies, tissue immune surveillance, and resolution of inflammation. The functional diversity of macrophages is enabled by dist
Externí odkaz:
https://doaj.org/article/8f90a6074da94b92a1e702e643c15732
Autor:
Shan Huang, Kristina A. Thomsson, Chunsheng Jin, Henrik Ryberg, Nabangshu Das, André Struglics, Ola Rolfson, Lena I. Björkman, Thomas Eisler, Tannin A. Schmidt, Gregory D. Jay, Roman Krawetz, Niclas G. Karlsson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The primary aim of the study was to identify inflammatory markers relevant for osteoarthritis (OA)-related systemic (plasma) and local (synovial fluid, SF) inflammation. From this, we looked for inflammatory markers that coincided with the increased
Externí odkaz:
https://doaj.org/article/6b701682bbad4a48b68b04253d62c085
Autor:
Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Holly Richendrfer, Tannin A. Schmidt, Khaled A. Elsaid
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-16 (2020)
Abstract Background Synovial tissue fibrosis is common in advanced OA with features including the presence of stress fiber-positive myofibroblasts and deposition of cross-linked collagen type-I. Proteoglycan-4 (PRG4) is a mucinous glycoprotein secret
Externí odkaz:
https://doaj.org/article/5dd97d15ec474874a9a0dbc67ead04e1
Autor:
Meghana Pendyala, Paige S Woods, Douglas K Brubaker, Elizabeth A Blaber, Tannin A Schmidt, Deva D Chan
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0267921 (2022)
Synovial fluid is composed of hyaluronan and proteoglycan-4 (PRG4 or lubricin), which work synergistically to maintain joint lubrication. In diseases like osteoarthritis, hyaluronan and PRG4 concentrations can be altered, resulting in lowered synovia
Externí odkaz:
https://doaj.org/article/9ed021c9513346fa8cc93e2a5519aa2d